Disruption of bradycardia associated with discriminative conditioning in combat veterans with PTSD
Jay P Ginsberg1,2, Edwin Ayers3, Louisa Burriss1, Donald A Powell1,41Shirley L. Buchanan Neuroscience Laboratory, Dorn VA Medical Center, Columbia, SC, USA; 2Department of Pharmacology, Physiology, and Neuroscience, School of Medicine, 4Department of Psychology, University of South Carolina, Columbi...
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Dove Medical Press
2008
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oai:doaj.org-article:0129dc150db74baa8a58731ff7df7feb2021-12-02T06:28:55ZDisruption of bradycardia associated with discriminative conditioning in combat veterans with PTSD1176-63281178-2021https://doaj.org/article/0129dc150db74baa8a58731ff7df7feb2008-06-01T00:00:00Zhttp://www.dovepress.com/disruption-of-bradycardia-associated-with-discriminative-conditioning--a1873https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Jay P Ginsberg1,2, Edwin Ayers3, Louisa Burriss1, Donald A Powell1,41Shirley L. Buchanan Neuroscience Laboratory, Dorn VA Medical Center, Columbia, SC, USA; 2Department of Pharmacology, Physiology, and Neuroscience, School of Medicine, 4Department of Psychology, University of South Carolina, Columbia, SC, USA; 3Department of Psychology, South Carolina State University, Orangeburg, SC, USAAbstract: The effects of combat-related posttraumatic stress disorder (PTSD) on heart rate (HR) responding associated with a discriminative delay eyeblink (EB) conditioning paradigm are reported. Combat PTSD+, Combat PTSD−, and Noncombat PTSD− veterans were assessed with psychometric self-report measures, and baseline heart rate variability (HRV) was measured before receiving a 72-trial session of discriminative EB classical conditioning. Two types (red or green light) of conditioned stimuli (CS) were used: one (CS+) predicted a tone, followed immediately by an aversive stimulus (corneal airpuff); the other (CS−) predicted a tone alone, not followed by the airpuff. The light signal was presented for 5 seconds, during which HR was measured. On all psychometric measures, the PTSD+ subgroup was significantly different from the PTSD− subgroups (Combat + Noncombat), and the PTSD− subgroups did not significantly differ from each other. A linear deceleration in HR to CS+ and CS− signals was found in the combined PTSD− subgroup and on CS− trials in the PTSD+ subgroup, but was not present on CS+ trials in the PTSD+ subgroup. Results are interpreted with respect to a behavioral stages model of conditioned bradycardia and in terms of neural substrates which are both critical to HR conditioning and known to be abnormal in PTSD.Keywords: bradycardia, PTSD, combat veterans, classical conditioning Jay P GinsbergEdwin AyersLouisa BurrissDonald A PowellDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2008, Iss Issue 3, Pp 635-646 (2008) |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Jay P Ginsberg Edwin Ayers Louisa Burriss Donald A Powell Disruption of bradycardia associated with discriminative conditioning in combat veterans with PTSD |
| description |
Jay P Ginsberg1,2, Edwin Ayers3, Louisa Burriss1, Donald A Powell1,41Shirley L. Buchanan Neuroscience Laboratory, Dorn VA Medical Center, Columbia, SC, USA; 2Department of Pharmacology, Physiology, and Neuroscience, School of Medicine, 4Department of Psychology, University of South Carolina, Columbia, SC, USA; 3Department of Psychology, South Carolina State University, Orangeburg, SC, USAAbstract: The effects of combat-related posttraumatic stress disorder (PTSD) on heart rate (HR) responding associated with a discriminative delay eyeblink (EB) conditioning paradigm are reported. Combat PTSD+, Combat PTSD−, and Noncombat PTSD− veterans were assessed with psychometric self-report measures, and baseline heart rate variability (HRV) was measured before receiving a 72-trial session of discriminative EB classical conditioning. Two types (red or green light) of conditioned stimuli (CS) were used: one (CS+) predicted a tone, followed immediately by an aversive stimulus (corneal airpuff); the other (CS−) predicted a tone alone, not followed by the airpuff. The light signal was presented for 5 seconds, during which HR was measured. On all psychometric measures, the PTSD+ subgroup was significantly different from the PTSD− subgroups (Combat + Noncombat), and the PTSD− subgroups did not significantly differ from each other. A linear deceleration in HR to CS+ and CS− signals was found in the combined PTSD− subgroup and on CS− trials in the PTSD+ subgroup, but was not present on CS+ trials in the PTSD+ subgroup. Results are interpreted with respect to a behavioral stages model of conditioned bradycardia and in terms of neural substrates which are both critical to HR conditioning and known to be abnormal in PTSD.Keywords: bradycardia, PTSD, combat veterans, classical conditioning |
| format |
article |
| author |
Jay P Ginsberg Edwin Ayers Louisa Burriss Donald A Powell |
| author_facet |
Jay P Ginsberg Edwin Ayers Louisa Burriss Donald A Powell |
| author_sort |
Jay P Ginsberg |
| title |
Disruption of bradycardia associated with discriminative conditioning in combat veterans with PTSD |
| title_short |
Disruption of bradycardia associated with discriminative conditioning in combat veterans with PTSD |
| title_full |
Disruption of bradycardia associated with discriminative conditioning in combat veterans with PTSD |
| title_fullStr |
Disruption of bradycardia associated with discriminative conditioning in combat veterans with PTSD |
| title_full_unstemmed |
Disruption of bradycardia associated with discriminative conditioning in combat veterans with PTSD |
| title_sort |
disruption of bradycardia associated with discriminative conditioning in combat veterans with ptsd |
| publisher |
Dove Medical Press |
| publishDate |
2008 |
| url |
https://doaj.org/article/0129dc150db74baa8a58731ff7df7feb |
| work_keys_str_mv |
AT jaypginsberg disruptionofbradycardiaassociatedwithdiscriminativeconditioningincombatveteranswithptsd AT edwinayers disruptionofbradycardiaassociatedwithdiscriminativeconditioningincombatveteranswithptsd AT louisaburriss disruptionofbradycardiaassociatedwithdiscriminativeconditioningincombatveteranswithptsd AT donaldapowell disruptionofbradycardiaassociatedwithdiscriminativeconditioningincombatveteranswithptsd |
| _version_ |
1718399852859097088 |