Dietary butyrate glycerides modulate intestinal microbiota composition and serum metabolites in broilers

Abstract Butyrate can modulate the immune response and energy expenditure of animals and enhance intestinal health. The present study investigated changes in the intestinal microbiota composition and serum metabolites of young broilers in response to 3,000 ppm butyrate in the form of butyrate glycer...

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Autores principales:	Xiaojian Yang, Fugui Yin, Yuhui Yang, Dion Lepp, Hai Yu, Zheng Ruan, Chengbo Yang, Yulong Yin, Yongqing Hou, Steve Leeson, Joshua Gong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/013703c544f74cc482eba1f6b20c4b37
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spelling	oai:doaj.org-article:013703c544f74cc482eba1f6b20c4b372021-12-02T15:08:35ZDietary butyrate glycerides modulate intestinal microbiota composition and serum metabolites in broilers10.1038/s41598-018-22565-62045-2322https://doaj.org/article/013703c544f74cc482eba1f6b20c4b372018-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-22565-6https://doaj.org/toc/2045-2322Abstract Butyrate can modulate the immune response and energy expenditure of animals and enhance intestinal health. The present study investigated changes in the intestinal microbiota composition and serum metabolites of young broilers in response to 3,000 ppm butyrate in the form of butyrate glycerides (BG) via pyrosequencing of bacterial 16S rRNA genes and nuclear magnetic resonance (NMR). The dietary treatment did not affect the alpha diversity of intestinal microbiota, but altered its composition. Thirty-nine key operational taxonomic units (OTUs) in differentiating cecal microbiota community structures between BG treated and untreated chickens were also identified. Bifidobacterium was, in particular, affected by the dietary treatment significantly, showing an increase in not only the abundance (approximately 3 fold, P ≤ 0.05) but also the species diversity. The (NMR)-based analysis revealed an increase in serum concentrations of alanine, low-density and very low-density lipoproteins, and lipids (P ≤ 0.05) by BG. More interestingly, the dietary treatment also boosted (P ≤ 0.05) serum concentrations of bacterial metabolites, including choline, glycerophosphorylcholine, dimethylamine, trimethylamine, trimethylamine-N-oxide, lactate, and succinate. In conclusion, the data suggest the modulation of intestinal microbiota and serum metabolites by BG dietary treatment and potential contribution of intestinal bacteria to lipid metabolism/energy homeostasis in broilers.Xiaojian YangFugui YinYuhui YangDion LeppHai YuZheng RuanChengbo YangYulong YinYongqing HouSteve LeesonJoshua GongNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiaojian Yang Fugui Yin Yuhui Yang Dion Lepp Hai Yu Zheng Ruan Chengbo Yang Yulong Yin Yongqing Hou Steve Leeson Joshua Gong Dietary butyrate glycerides modulate intestinal microbiota composition and serum metabolites in broilers
description	Abstract Butyrate can modulate the immune response and energy expenditure of animals and enhance intestinal health. The present study investigated changes in the intestinal microbiota composition and serum metabolites of young broilers in response to 3,000 ppm butyrate in the form of butyrate glycerides (BG) via pyrosequencing of bacterial 16S rRNA genes and nuclear magnetic resonance (NMR). The dietary treatment did not affect the alpha diversity of intestinal microbiota, but altered its composition. Thirty-nine key operational taxonomic units (OTUs) in differentiating cecal microbiota community structures between BG treated and untreated chickens were also identified. Bifidobacterium was, in particular, affected by the dietary treatment significantly, showing an increase in not only the abundance (approximately 3 fold, P ≤ 0.05) but also the species diversity. The (NMR)-based analysis revealed an increase in serum concentrations of alanine, low-density and very low-density lipoproteins, and lipids (P ≤ 0.05) by BG. More interestingly, the dietary treatment also boosted (P ≤ 0.05) serum concentrations of bacterial metabolites, including choline, glycerophosphorylcholine, dimethylamine, trimethylamine, trimethylamine-N-oxide, lactate, and succinate. In conclusion, the data suggest the modulation of intestinal microbiota and serum metabolites by BG dietary treatment and potential contribution of intestinal bacteria to lipid metabolism/energy homeostasis in broilers.
format	article
author	Xiaojian Yang Fugui Yin Yuhui Yang Dion Lepp Hai Yu Zheng Ruan Chengbo Yang Yulong Yin Yongqing Hou Steve Leeson Joshua Gong
author_facet	Xiaojian Yang Fugui Yin Yuhui Yang Dion Lepp Hai Yu Zheng Ruan Chengbo Yang Yulong Yin Yongqing Hou Steve Leeson Joshua Gong
author_sort	Xiaojian Yang
title	Dietary butyrate glycerides modulate intestinal microbiota composition and serum metabolites in broilers
title_short	Dietary butyrate glycerides modulate intestinal microbiota composition and serum metabolites in broilers
title_full	Dietary butyrate glycerides modulate intestinal microbiota composition and serum metabolites in broilers
title_fullStr	Dietary butyrate glycerides modulate intestinal microbiota composition and serum metabolites in broilers
title_full_unstemmed	Dietary butyrate glycerides modulate intestinal microbiota composition and serum metabolites in broilers
title_sort	dietary butyrate glycerides modulate intestinal microbiota composition and serum metabolites in broilers
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/013703c544f74cc482eba1f6b20c4b37
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_version_	1718388039198179328

Dietary butyrate glycerides modulate intestinal microbiota composition and serum metabolites in broilers

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