Whole proteome analysis of human tankyrase knockout cells reveals targets of tankyrase-mediated degradation

Tankyrase 1 and 2 are poly(ADP-ribose) polymerases that mark proteins for degradation, but there is a current lack of knowledge about their distinct functions and substrates. Here, the authors elucidate the cellular roles and substrates of these polymerases using comparative functional and proteomic...

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Autores principales:	Amit Bhardwaj, Yanling Yang, Beatrix Ueberheide, Susan Smith
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/013778b4668542dcb7be9914663032bd
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spelling	oai:doaj.org-article:013778b4668542dcb7be9914663032bd2021-12-02T14:41:58ZWhole proteome analysis of human tankyrase knockout cells reveals targets of tankyrase-mediated degradation10.1038/s41467-017-02363-w2041-1723https://doaj.org/article/013778b4668542dcb7be9914663032bd2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02363-whttps://doaj.org/toc/2041-1723Tankyrase 1 and 2 are poly(ADP-ribose) polymerases that mark proteins for degradation, but there is a current lack of knowledge about their distinct functions and substrates. Here, the authors elucidate the cellular roles and substrates of these polymerases using comparative functional and proteomics analyses of tankyrase knockout cell lines.Amit BhardwajYanling YangBeatrix UeberheideSusan SmithNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Amit Bhardwaj Yanling Yang Beatrix Ueberheide Susan Smith Whole proteome analysis of human tankyrase knockout cells reveals targets of tankyrase-mediated degradation
description	Tankyrase 1 and 2 are poly(ADP-ribose) polymerases that mark proteins for degradation, but there is a current lack of knowledge about their distinct functions and substrates. Here, the authors elucidate the cellular roles and substrates of these polymerases using comparative functional and proteomics analyses of tankyrase knockout cell lines.
format	article
author	Amit Bhardwaj Yanling Yang Beatrix Ueberheide Susan Smith
author_facet	Amit Bhardwaj Yanling Yang Beatrix Ueberheide Susan Smith
author_sort	Amit Bhardwaj
title	Whole proteome analysis of human tankyrase knockout cells reveals targets of tankyrase-mediated degradation
title_short	Whole proteome analysis of human tankyrase knockout cells reveals targets of tankyrase-mediated degradation
title_full	Whole proteome analysis of human tankyrase knockout cells reveals targets of tankyrase-mediated degradation
title_fullStr	Whole proteome analysis of human tankyrase knockout cells reveals targets of tankyrase-mediated degradation
title_full_unstemmed	Whole proteome analysis of human tankyrase knockout cells reveals targets of tankyrase-mediated degradation
title_sort	whole proteome analysis of human tankyrase knockout cells reveals targets of tankyrase-mediated degradation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/013778b4668542dcb7be9914663032bd
work_keys_str_mv	AT amitbhardwaj wholeproteomeanalysisofhumantankyraseknockoutcellsrevealstargetsoftankyrasemediateddegradation AT yanlingyang wholeproteomeanalysisofhumantankyraseknockoutcellsrevealstargetsoftankyrasemediateddegradation AT beatrixueberheide wholeproteomeanalysisofhumantankyraseknockoutcellsrevealstargetsoftankyrasemediateddegradation AT susansmith wholeproteomeanalysisofhumantankyraseknockoutcellsrevealstargetsoftankyrasemediateddegradation
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Whole proteome analysis of human tankyrase knockout cells reveals targets of tankyrase-mediated degradation

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