Whole proteome analysis of human tankyrase knockout cells reveals targets of tankyrase-mediated degradation
Tankyrase 1 and 2 are poly(ADP-ribose) polymerases that mark proteins for degradation, but there is a current lack of knowledge about their distinct functions and substrates. Here, the authors elucidate the cellular roles and substrates of these polymerases using comparative functional and proteomic...
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Autores principales: | Amit Bhardwaj, Yanling Yang, Beatrix Ueberheide, Susan Smith |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2017
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Materias: | |
Acceso en línea: | https://doaj.org/article/013778b4668542dcb7be9914663032bd |
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