Predictive factors of continuous negative extrathoracic pressure management failure in children with moderate to severe respiratory syncytial virus infection

Abstract Continuous negative extrathoracic pressure (CNEP) might be beneficial for children with severe respiratory tract infections. However, there are no available data on the predictors of its failure among individuals with respiratory syncytial virus (RSV) infections. Here, we conducted a retros...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Shingo Ishimori, Yo Okizuka, Satoshi Onishi, Tadashi Shinomoto, Hirotaka Minami
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/01389acae1f44907a2c6e30af02cacc7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:01389acae1f44907a2c6e30af02cacc7
record_format	dspace
spelling	oai:doaj.org-article:01389acae1f44907a2c6e30af02cacc72021-12-02T14:27:53ZPredictive factors of continuous negative extrathoracic pressure management failure in children with moderate to severe respiratory syncytial virus infection10.1038/s41598-021-87582-42045-2322https://doaj.org/article/01389acae1f44907a2c6e30af02cacc72021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87582-4https://doaj.org/toc/2045-2322Abstract Continuous negative extrathoracic pressure (CNEP) might be beneficial for children with severe respiratory tract infections. However, there are no available data on the predictors of its failure among individuals with respiratory syncytial virus (RSV) infections. Here, we conducted a retrospective cohort study between October 1, 2015 and October 31, 2018 in hospitalized children with moderate to severe symptoms of respiratory syncytial virus (RSV) infections. We divided 45 children requiring CNEP ventilation with a non-fluctuating negative pressure of − 12 cm H2O into two groups. They were classified based on improvement or deterioration of their respiratory disorder under CNEP ventilation (responder group: n = 27, failure group: n = 18). Based on the univariate analysis, the responder and failure groups significantly differed in terms of median age, days elapsed from RSV onset to the initiation of CNEP, white blood cell count (WBC), titer of venous pCO2, body temperature at admission, and modified Wood-Downes Score (mWDS) 6 h after initiating CNEP. Based on a logistic regression analysis adjusted for age < 1 year upon admission, less than 5 days elapsed from RSV onset to the initiation of CNEP, not high value of WBC and body temperature at admission, and high values of mWDS 6 h after initiating CNEP were found to be significant independent risk factors for CNEP ventilation failure. The former two variables were associated with less failure (odds ratio was approximately 5), and the latter two variables are associated with more failure (odds ratio was approximately 8–9). Thus, CNEP could be a valid option for children with moderate to severe RSV infections, especially in those who were aged > 1 year, and specific clinical and laboratory findings.Shingo IshimoriYo OkizukaSatoshi OnishiTadashi ShinomotoHirotaka MinamiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shingo Ishimori Yo Okizuka Satoshi Onishi Tadashi Shinomoto Hirotaka Minami Predictive factors of continuous negative extrathoracic pressure management failure in children with moderate to severe respiratory syncytial virus infection
description	Abstract Continuous negative extrathoracic pressure (CNEP) might be beneficial for children with severe respiratory tract infections. However, there are no available data on the predictors of its failure among individuals with respiratory syncytial virus (RSV) infections. Here, we conducted a retrospective cohort study between October 1, 2015 and October 31, 2018 in hospitalized children with moderate to severe symptoms of respiratory syncytial virus (RSV) infections. We divided 45 children requiring CNEP ventilation with a non-fluctuating negative pressure of − 12 cm H2O into two groups. They were classified based on improvement or deterioration of their respiratory disorder under CNEP ventilation (responder group: n = 27, failure group: n = 18). Based on the univariate analysis, the responder and failure groups significantly differed in terms of median age, days elapsed from RSV onset to the initiation of CNEP, white blood cell count (WBC), titer of venous pCO2, body temperature at admission, and modified Wood-Downes Score (mWDS) 6 h after initiating CNEP. Based on a logistic regression analysis adjusted for age < 1 year upon admission, less than 5 days elapsed from RSV onset to the initiation of CNEP, not high value of WBC and body temperature at admission, and high values of mWDS 6 h after initiating CNEP were found to be significant independent risk factors for CNEP ventilation failure. The former two variables were associated with less failure (odds ratio was approximately 5), and the latter two variables are associated with more failure (odds ratio was approximately 8–9). Thus, CNEP could be a valid option for children with moderate to severe RSV infections, especially in those who were aged > 1 year, and specific clinical and laboratory findings.
format	article
author	Shingo Ishimori Yo Okizuka Satoshi Onishi Tadashi Shinomoto Hirotaka Minami
author_facet	Shingo Ishimori Yo Okizuka Satoshi Onishi Tadashi Shinomoto Hirotaka Minami
author_sort	Shingo Ishimori
title	Predictive factors of continuous negative extrathoracic pressure management failure in children with moderate to severe respiratory syncytial virus infection
title_short	Predictive factors of continuous negative extrathoracic pressure management failure in children with moderate to severe respiratory syncytial virus infection
title_full	Predictive factors of continuous negative extrathoracic pressure management failure in children with moderate to severe respiratory syncytial virus infection
title_fullStr	Predictive factors of continuous negative extrathoracic pressure management failure in children with moderate to severe respiratory syncytial virus infection
title_full_unstemmed	Predictive factors of continuous negative extrathoracic pressure management failure in children with moderate to severe respiratory syncytial virus infection
title_sort	predictive factors of continuous negative extrathoracic pressure management failure in children with moderate to severe respiratory syncytial virus infection
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/01389acae1f44907a2c6e30af02cacc7
work_keys_str_mv	AT shingoishimori predictivefactorsofcontinuousnegativeextrathoracicpressuremanagementfailureinchildrenwithmoderatetosevererespiratorysyncytialvirusinfection AT yookizuka predictivefactorsofcontinuousnegativeextrathoracicpressuremanagementfailureinchildrenwithmoderatetosevererespiratorysyncytialvirusinfection AT satoshionishi predictivefactorsofcontinuousnegativeextrathoracicpressuremanagementfailureinchildrenwithmoderatetosevererespiratorysyncytialvirusinfection AT tadashishinomoto predictivefactorsofcontinuousnegativeextrathoracicpressuremanagementfailureinchildrenwithmoderatetosevererespiratorysyncytialvirusinfection AT hirotakaminami predictivefactorsofcontinuousnegativeextrathoracicpressuremanagementfailureinchildrenwithmoderatetosevererespiratorysyncytialvirusinfection
_version_	1718391230889459712

Predictive factors of continuous negative extrathoracic pressure management failure in children with moderate to severe respiratory syncytial virus infection

Ejemplares similares