Sevoflurane Promotes Neurodegeneration Through Inflammasome Formation in APP/PS1 Mice

Sevoflurane (SEVO) is a highly fluorinated methyl isopropyl ether used as an inhalational anesthetic for general anesthesia. Previous studies have shown that SEVO may induce impaired memory and recognition ability and may be associated with neurodegenerative disease, e.g., Alzheimer’s disease (AD)....

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Autores principales:	Guohua Li, Yu Wang, Fang Cao, Dawei Wang, Limin Zhou, Yanwu Jin
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	sevoflurane (SEVO) Alzheimer’s disease (AD) NLRP3 BDNF neurodegenaration Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/013c29a205304399a952675c90aa89bb
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spelling	oai:doaj.org-article:013c29a205304399a952675c90aa89bb2021-12-02T11:40:25ZSevoflurane Promotes Neurodegeneration Through Inflammasome Formation in APP/PS1 Mice1662-453X10.3389/fnins.2021.647136https://doaj.org/article/013c29a205304399a952675c90aa89bb2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnins.2021.647136/fullhttps://doaj.org/toc/1662-453XSevoflurane (SEVO) is a highly fluorinated methyl isopropyl ether used as an inhalational anesthetic for general anesthesia. Previous studies have shown that SEVO may induce impaired memory and recognition ability and may be associated with neurodegenerative disease, e.g., Alzheimer’s disease (AD). However, the underlying mechanism remains unknown. Here, we used a mouse AD model, APP/PS1, to study the effects of SEVO on neurodegeneration occurring in AD. We found that SEVO exposure significantly impaired the spatial reference memory, sensorimotor, and cognitive function of the mice. Mechanistically, we found that SEVO induced formation of NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome and its downstream caspase 1-mediated production of IL-1β and IL-18, which subsequently deactivated brain-derived neurotrophic factor (BDNF) to promote neurodegeneration. Together, these data suggest that NLRP3 inflammasome is essential for SEVO-induced AD.Guohua LiYu WangFang CaoDawei WangLimin ZhouYanwu JinFrontiers Media S.A.articlesevoflurane (SEVO)Alzheimer’s disease (AD)NLRP3BDNFneurodegenarationNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	sevoflurane (SEVO) Alzheimer’s disease (AD) NLRP3 BDNF neurodegenaration Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	sevoflurane (SEVO) Alzheimer’s disease (AD) NLRP3 BDNF neurodegenaration Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Guohua Li Yu Wang Fang Cao Dawei Wang Limin Zhou Yanwu Jin Sevoflurane Promotes Neurodegeneration Through Inflammasome Formation in APP/PS1 Mice
description	Sevoflurane (SEVO) is a highly fluorinated methyl isopropyl ether used as an inhalational anesthetic for general anesthesia. Previous studies have shown that SEVO may induce impaired memory and recognition ability and may be associated with neurodegenerative disease, e.g., Alzheimer’s disease (AD). However, the underlying mechanism remains unknown. Here, we used a mouse AD model, APP/PS1, to study the effects of SEVO on neurodegeneration occurring in AD. We found that SEVO exposure significantly impaired the spatial reference memory, sensorimotor, and cognitive function of the mice. Mechanistically, we found that SEVO induced formation of NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome and its downstream caspase 1-mediated production of IL-1β and IL-18, which subsequently deactivated brain-derived neurotrophic factor (BDNF) to promote neurodegeneration. Together, these data suggest that NLRP3 inflammasome is essential for SEVO-induced AD.
format	article
author	Guohua Li Yu Wang Fang Cao Dawei Wang Limin Zhou Yanwu Jin
author_facet	Guohua Li Yu Wang Fang Cao Dawei Wang Limin Zhou Yanwu Jin
author_sort	Guohua Li
title	Sevoflurane Promotes Neurodegeneration Through Inflammasome Formation in APP/PS1 Mice
title_short	Sevoflurane Promotes Neurodegeneration Through Inflammasome Formation in APP/PS1 Mice
title_full	Sevoflurane Promotes Neurodegeneration Through Inflammasome Formation in APP/PS1 Mice
title_fullStr	Sevoflurane Promotes Neurodegeneration Through Inflammasome Formation in APP/PS1 Mice
title_full_unstemmed	Sevoflurane Promotes Neurodegeneration Through Inflammasome Formation in APP/PS1 Mice
title_sort	sevoflurane promotes neurodegeneration through inflammasome formation in app/ps1 mice
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/013c29a205304399a952675c90aa89bb
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Sevoflurane Promotes Neurodegeneration Through Inflammasome Formation in APP/PS1 Mice

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