Sequence variants with large effects on cardiac electrophysiology and disease

Aberrant morphology of the QRS complex in an electrocardiogram can be associated with cardiac morbidity and mortality. Here, the authors perform genome-wide association studies for ten measures of the QRS complex in 81,192 individuals and find 86 previously unreported loci that associate with at lea...

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Autores principales:	Kristjan Norland, Gardar Sveinbjornsson, Rosa B. Thorolfsdottir, Olafur B. Davidsson, Vinicius Tragante, Sridharan Rajamani, Anna Helgadottir, Solveig Gretarsdottir, Jessica van Setten, Folkert W. Asselbergs, Jon Th. Sverrisson, Sigurdur S. Stephensen, Gylfi Oskarsson, Emil L. Sigurdsson, Karl Andersen, Ragnar Danielsen, Gudmundur Thorgeirsson, Unnur Thorsteinsdottir, David O. Arnar, Patrick Sulem, Hilma Holm, Daniel F. Gudbjartsson, Kari Stefansson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/013cd3a5a1cd47ec9888561074de6288
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spelling	oai:doaj.org-article:013cd3a5a1cd47ec9888561074de62882021-12-02T14:39:59ZSequence variants with large effects on cardiac electrophysiology and disease10.1038/s41467-019-12682-92041-1723https://doaj.org/article/013cd3a5a1cd47ec9888561074de62882019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12682-9https://doaj.org/toc/2041-1723Aberrant morphology of the QRS complex in an electrocardiogram can be associated with cardiac morbidity and mortality. Here, the authors perform genome-wide association studies for ten measures of the QRS complex in 81,192 individuals and find 86 previously unreported loci that associate with at least one parameter.Kristjan NorlandGardar SveinbjornssonRosa B. ThorolfsdottirOlafur B. DavidssonVinicius TraganteSridharan RajamaniAnna HelgadottirSolveig GretarsdottirJessica van SettenFolkert W. AsselbergsJon Th. SverrissonSigurdur S. StephensenGylfi OskarssonEmil L. SigurdssonKarl AndersenRagnar DanielsenGudmundur ThorgeirssonUnnur ThorsteinsdottirDavid O. ArnarPatrick SulemHilma HolmDaniel F. GudbjartssonKari StefanssonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kristjan Norland Gardar Sveinbjornsson Rosa B. Thorolfsdottir Olafur B. Davidsson Vinicius Tragante Sridharan Rajamani Anna Helgadottir Solveig Gretarsdottir Jessica van Setten Folkert W. Asselbergs Jon Th. Sverrisson Sigurdur S. Stephensen Gylfi Oskarsson Emil L. Sigurdsson Karl Andersen Ragnar Danielsen Gudmundur Thorgeirsson Unnur Thorsteinsdottir David O. Arnar Patrick Sulem Hilma Holm Daniel F. Gudbjartsson Kari Stefansson Sequence variants with large effects on cardiac electrophysiology and disease
description	Aberrant morphology of the QRS complex in an electrocardiogram can be associated with cardiac morbidity and mortality. Here, the authors perform genome-wide association studies for ten measures of the QRS complex in 81,192 individuals and find 86 previously unreported loci that associate with at least one parameter.
format	article
author	Kristjan Norland Gardar Sveinbjornsson Rosa B. Thorolfsdottir Olafur B. Davidsson Vinicius Tragante Sridharan Rajamani Anna Helgadottir Solveig Gretarsdottir Jessica van Setten Folkert W. Asselbergs Jon Th. Sverrisson Sigurdur S. Stephensen Gylfi Oskarsson Emil L. Sigurdsson Karl Andersen Ragnar Danielsen Gudmundur Thorgeirsson Unnur Thorsteinsdottir David O. Arnar Patrick Sulem Hilma Holm Daniel F. Gudbjartsson Kari Stefansson
author_facet	Kristjan Norland Gardar Sveinbjornsson Rosa B. Thorolfsdottir Olafur B. Davidsson Vinicius Tragante Sridharan Rajamani Anna Helgadottir Solveig Gretarsdottir Jessica van Setten Folkert W. Asselbergs Jon Th. Sverrisson Sigurdur S. Stephensen Gylfi Oskarsson Emil L. Sigurdsson Karl Andersen Ragnar Danielsen Gudmundur Thorgeirsson Unnur Thorsteinsdottir David O. Arnar Patrick Sulem Hilma Holm Daniel F. Gudbjartsson Kari Stefansson
author_sort	Kristjan Norland
title	Sequence variants with large effects on cardiac electrophysiology and disease
title_short	Sequence variants with large effects on cardiac electrophysiology and disease
title_full	Sequence variants with large effects on cardiac electrophysiology and disease
title_fullStr	Sequence variants with large effects on cardiac electrophysiology and disease
title_full_unstemmed	Sequence variants with large effects on cardiac electrophysiology and disease
title_sort	sequence variants with large effects on cardiac electrophysiology and disease
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/013cd3a5a1cd47ec9888561074de6288
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Sequence variants with large effects on cardiac electrophysiology and disease

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