The effect of X-linked dosage compensation on complex trait variation

Dosage compensation (DC) on the X chromosome has predictable effects on genetic and phenotypic trait variance. Here, the authors use information for 20 quantitative traits in the UK Biobank and across-tissue gene expression to compare X-linked heritability and the effects of trait-associated SNPs be...

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Autores principales:	Julia Sidorenko, Irfahan Kassam, Kathryn E. Kemper, Jian Zeng, Luke R. Lloyd-Jones, Grant W. Montgomery, Greg Gibson, Andres Metspalu, Tonu Esko, Jian Yang, Allan F. McRae, Peter M. Visscher
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/013d3c416c61462f8755c27f7c64fc0a
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spelling	oai:doaj.org-article:013d3c416c61462f8755c27f7c64fc0a2021-12-02T15:35:26ZThe effect of X-linked dosage compensation on complex trait variation10.1038/s41467-019-10598-y2041-1723https://doaj.org/article/013d3c416c61462f8755c27f7c64fc0a2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10598-yhttps://doaj.org/toc/2041-1723Dosage compensation (DC) on the X chromosome has predictable effects on genetic and phenotypic trait variance. Here, the authors use information for 20 quantitative traits in the UK Biobank and across-tissue gene expression to compare X-linked heritability and the effects of trait-associated SNPs between the sexes.Julia SidorenkoIrfahan KassamKathryn E. KemperJian ZengLuke R. Lloyd-JonesGrant W. MontgomeryGreg GibsonAndres MetspaluTonu EskoJian YangAllan F. McRaePeter M. VisscherNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Julia Sidorenko Irfahan Kassam Kathryn E. Kemper Jian Zeng Luke R. Lloyd-Jones Grant W. Montgomery Greg Gibson Andres Metspalu Tonu Esko Jian Yang Allan F. McRae Peter M. Visscher The effect of X-linked dosage compensation on complex trait variation
description	Dosage compensation (DC) on the X chromosome has predictable effects on genetic and phenotypic trait variance. Here, the authors use information for 20 quantitative traits in the UK Biobank and across-tissue gene expression to compare X-linked heritability and the effects of trait-associated SNPs between the sexes.
format	article
author	Julia Sidorenko Irfahan Kassam Kathryn E. Kemper Jian Zeng Luke R. Lloyd-Jones Grant W. Montgomery Greg Gibson Andres Metspalu Tonu Esko Jian Yang Allan F. McRae Peter M. Visscher
author_facet	Julia Sidorenko Irfahan Kassam Kathryn E. Kemper Jian Zeng Luke R. Lloyd-Jones Grant W. Montgomery Greg Gibson Andres Metspalu Tonu Esko Jian Yang Allan F. McRae Peter M. Visscher
author_sort	Julia Sidorenko
title	The effect of X-linked dosage compensation on complex trait variation
title_short	The effect of X-linked dosage compensation on complex trait variation
title_full	The effect of X-linked dosage compensation on complex trait variation
title_fullStr	The effect of X-linked dosage compensation on complex trait variation
title_full_unstemmed	The effect of X-linked dosage compensation on complex trait variation
title_sort	effect of x-linked dosage compensation on complex trait variation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/013d3c416c61462f8755c27f7c64fc0a
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The effect of X-linked dosage compensation on complex trait variation

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