RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming

N6-methyladenosine (m6A) is a reversible mRNA modification with important roles in cancer biology and immunoregulation. Here, the authors show that myeloid-specific deletion of Mettl3, the catalytic subunit of the methyltransferase complex, promotes tumor growth and metastasis in preclinical tumor m...

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Autores principales:	Huilong Yin, Xiang Zhang, Pengyuan Yang, Xiaofang Zhang, Yingran Peng, Da Li, Yanping Yu, Ye Wu, Yidi Wang, Jinbao Zhang, Xiaochen Ding, Xiangpeng Wang, Angang Yang, Rui Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/013f4347490a418eb0ba0440e7fbe53f
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spelling	oai:doaj.org-article:013f4347490a418eb0ba0440e7fbe53f2021-12-02T13:34:44ZRNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming10.1038/s41467-021-21514-82041-1723https://doaj.org/article/013f4347490a418eb0ba0440e7fbe53f2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21514-8https://doaj.org/toc/2041-1723N6-methyladenosine (m6A) is a reversible mRNA modification with important roles in cancer biology and immunoregulation. Here, the authors show that myeloid-specific deletion of Mettl3, the catalytic subunit of the methyltransferase complex, promotes tumor growth and metastasis in preclinical tumor models, influencing macrophage reprogramming and attenuating PD-1 blockade.Huilong YinXiang ZhangPengyuan YangXiaofang ZhangYingran PengDa LiYanping YuYe WuYidi WangJinbao ZhangXiaochen DingXiangpeng WangAngang YangRui ZhangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Huilong Yin Xiang Zhang Pengyuan Yang Xiaofang Zhang Yingran Peng Da Li Yanping Yu Ye Wu Yidi Wang Jinbao Zhang Xiaochen Ding Xiangpeng Wang Angang Yang Rui Zhang RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming
description	N6-methyladenosine (m6A) is a reversible mRNA modification with important roles in cancer biology and immunoregulation. Here, the authors show that myeloid-specific deletion of Mettl3, the catalytic subunit of the methyltransferase complex, promotes tumor growth and metastasis in preclinical tumor models, influencing macrophage reprogramming and attenuating PD-1 blockade.
format	article
author	Huilong Yin Xiang Zhang Pengyuan Yang Xiaofang Zhang Yingran Peng Da Li Yanping Yu Ye Wu Yidi Wang Jinbao Zhang Xiaochen Ding Xiangpeng Wang Angang Yang Rui Zhang
author_facet	Huilong Yin Xiang Zhang Pengyuan Yang Xiaofang Zhang Yingran Peng Da Li Yanping Yu Ye Wu Yidi Wang Jinbao Zhang Xiaochen Ding Xiangpeng Wang Angang Yang Rui Zhang
author_sort	Huilong Yin
title	RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming
title_short	RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming
title_full	RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming
title_fullStr	RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming
title_full_unstemmed	RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming
title_sort	rna m6a methylation orchestrates cancer growth and metastasis via macrophage reprogramming
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/013f4347490a418eb0ba0440e7fbe53f
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RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming

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