VEGFA GENE POLYMORPHISM (С-2578A, C+936T) IN PATIENTS WITH BREAST CANCER

Abstract. Angiogenesis plays the major role in growth, progression and metastasis of different solid umors. Vascular endothelium growth factor (VEGF) is a basic factor of angiogenesis regulation. The aim of present study was to evaluate possible correlations between C-2578A and C+936T VEGFА gene fun...

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Autores principales:	A. V. Shevchenko, V. I. Konenkov, O. V. Golovanova, A. E. Blagodatskikh, E. Yu. Garbukov, M. N. Stakheeva
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	breast cancer vegfa gene polymorphism lymphogenic metastases menstrual status Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/013fe91d1e6544e6bbe49e022264cde4
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spelling	oai:doaj.org-article:013fe91d1e6544e6bbe49e022264cde42021-11-18T08:03:40ZVEGFA GENE POLYMORPHISM (С-2578A, C+936T) IN PATIENTS WITH BREAST CANCER1563-06252313-741X10.15789/1563-0625-2012-1-2-87-94https://doaj.org/article/013fe91d1e6544e6bbe49e022264cde42014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/301https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Angiogenesis plays the major role in growth, progression and metastasis of different solid umors. Vascular endothelium growth factor (VEGF) is a basic factor of angiogenesis regulation. The aim of present study was to evaluate possible correlations between C-2578A and C+936T VEGFА gene functional polymorphisms, and risk of breast cancer development. An association of -2578AA and -2578СС /+936СС VEGFA polymorphisms with incidence of breast cancer was revealed in our study. Distinct features of VEGFA genotype distribution were found for women with lymphogenic metastases and differences in menstrual status.A. V. ShevchenkoV. I. KonenkovO. V. GolovanovaA. E. BlagodatskikhE. Yu. GarbukovM. N. StakheevaSPb RAACIarticlebreast cancervegfa gene polymorphismlymphogenic metastasesmenstrual statusImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 14, Iss 1-2, Pp 87-94 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	breast cancer vegfa gene polymorphism lymphogenic metastases menstrual status Immunologic diseases. Allergy RC581-607
spellingShingle	breast cancer vegfa gene polymorphism lymphogenic metastases menstrual status Immunologic diseases. Allergy RC581-607 A. V. Shevchenko V. I. Konenkov O. V. Golovanova A. E. Blagodatskikh E. Yu. Garbukov M. N. Stakheeva VEGFA GENE POLYMORPHISM (С-2578A, C+936T) IN PATIENTS WITH BREAST CANCER
description	Abstract. Angiogenesis plays the major role in growth, progression and metastasis of different solid umors. Vascular endothelium growth factor (VEGF) is a basic factor of angiogenesis regulation. The aim of present study was to evaluate possible correlations between C-2578A and C+936T VEGFА gene functional polymorphisms, and risk of breast cancer development. An association of -2578AA and -2578СС /+936СС VEGFA polymorphisms with incidence of breast cancer was revealed in our study. Distinct features of VEGFA genotype distribution were found for women with lymphogenic metastases and differences in menstrual status.
format	article
author	A. V. Shevchenko V. I. Konenkov O. V. Golovanova A. E. Blagodatskikh E. Yu. Garbukov M. N. Stakheeva
author_facet	A. V. Shevchenko V. I. Konenkov O. V. Golovanova A. E. Blagodatskikh E. Yu. Garbukov M. N. Stakheeva
author_sort	A. V. Shevchenko
title	VEGFA GENE POLYMORPHISM (С-2578A, C+936T) IN PATIENTS WITH BREAST CANCER
title_short	VEGFA GENE POLYMORPHISM (С-2578A, C+936T) IN PATIENTS WITH BREAST CANCER
title_full	VEGFA GENE POLYMORPHISM (С-2578A, C+936T) IN PATIENTS WITH BREAST CANCER
title_fullStr	VEGFA GENE POLYMORPHISM (С-2578A, C+936T) IN PATIENTS WITH BREAST CANCER
title_full_unstemmed	VEGFA GENE POLYMORPHISM (С-2578A, C+936T) IN PATIENTS WITH BREAST CANCER
title_sort	vegfa gene polymorphism (с-2578a, c+936t) in patients with breast cancer
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/013fe91d1e6544e6bbe49e022264cde4
work_keys_str_mv	AT avshevchenko vegfagenepolymorphisms2578ac936tinpatientswithbreastcancer AT vikonenkov vegfagenepolymorphisms2578ac936tinpatientswithbreastcancer AT ovgolovanova vegfagenepolymorphisms2578ac936tinpatientswithbreastcancer AT aeblagodatskikh vegfagenepolymorphisms2578ac936tinpatientswithbreastcancer AT eyugarbukov vegfagenepolymorphisms2578ac936tinpatientswithbreastcancer AT mnstakheeva vegfagenepolymorphisms2578ac936tinpatientswithbreastcancer
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VEGFA GENE POLYMORPHISM (С-2578A, C+936T) IN PATIENTS WITH BREAST CANCER

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