Using paleogenomics to study the evolution of gene families: origin and duplication history of the relaxin family hormones and their receptors.

Recent progress in the analysis of whole genome sequencing data has resulted in the emergence of paleogenomics, a field devoted to the reconstruction of ancestral genomes. Ancestral karyotype reconstructions have been used primarily to illustrate the dynamic nature of genome evolution. In this paper...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sergey Yegorov, Sara Good
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0141f9684e85438d996507fca25454c5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0141f9684e85438d996507fca25454c5
record_format	dspace
spelling	oai:doaj.org-article:0141f9684e85438d996507fca25454c52021-11-18T07:24:35ZUsing paleogenomics to study the evolution of gene families: origin and duplication history of the relaxin family hormones and their receptors.1932-620310.1371/journal.pone.0032923https://doaj.org/article/0141f9684e85438d996507fca25454c52012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22470432/?tool=EBIhttps://doaj.org/toc/1932-6203Recent progress in the analysis of whole genome sequencing data has resulted in the emergence of paleogenomics, a field devoted to the reconstruction of ancestral genomes. Ancestral karyotype reconstructions have been used primarily to illustrate the dynamic nature of genome evolution. In this paper, we demonstrate how they can also be used to study individual gene families by examining the evolutionary history of relaxin hormones (RLN/INSL) and relaxin family peptide receptors (RXFP). Relaxin family hormones are members of the insulin superfamily, and are implicated in the regulation of a variety of primarily reproductive and neuroendocrine processes. Their receptors are G-protein coupled receptors (GPCR's) and include members of two distinct evolutionary groups, an unusual characteristic. Although several studies have tried to elucidate the origins of the relaxin peptide family, the evolutionary origin of their receptors and the mechanisms driving the diversification of the RLN/INSL-RXFP signaling systems in non-placental vertebrates has remained elusive. Here we show that the numerous vertebrate RLN/INSL and RXFP genes are products of an ancestral receptor-ligand system that originally consisted of three genes, two of which apparently trace their origins to invertebrates. Subsequently, diversification of the system was driven primarily by whole genome duplications (WGD, 2R and 3R) followed by almost complete retention of the ligand duplicates in most vertebrates but massive loss of receptor genes in tetrapods. Interestingly, the majority of 3R duplicates retained in teleosts are potentially involved in neuroendocrine regulation. Furthermore, we infer that the ancestral AncRxfp3/4 receptor may have been syntenically linked to the AncRln-like ligand in the pre-2R genome, and show that syntenic linkages among ligands and receptors have changed dynamically in different lineages. This study ultimately shows the broad utility, with some caveats, of incorporating paleogenomics data into understanding the evolution of gene families.Sergey YegorovSara GoodPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 3, p e32923 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sergey Yegorov Sara Good Using paleogenomics to study the evolution of gene families: origin and duplication history of the relaxin family hormones and their receptors.
description	Recent progress in the analysis of whole genome sequencing data has resulted in the emergence of paleogenomics, a field devoted to the reconstruction of ancestral genomes. Ancestral karyotype reconstructions have been used primarily to illustrate the dynamic nature of genome evolution. In this paper, we demonstrate how they can also be used to study individual gene families by examining the evolutionary history of relaxin hormones (RLN/INSL) and relaxin family peptide receptors (RXFP). Relaxin family hormones are members of the insulin superfamily, and are implicated in the regulation of a variety of primarily reproductive and neuroendocrine processes. Their receptors are G-protein coupled receptors (GPCR's) and include members of two distinct evolutionary groups, an unusual characteristic. Although several studies have tried to elucidate the origins of the relaxin peptide family, the evolutionary origin of their receptors and the mechanisms driving the diversification of the RLN/INSL-RXFP signaling systems in non-placental vertebrates has remained elusive. Here we show that the numerous vertebrate RLN/INSL and RXFP genes are products of an ancestral receptor-ligand system that originally consisted of three genes, two of which apparently trace their origins to invertebrates. Subsequently, diversification of the system was driven primarily by whole genome duplications (WGD, 2R and 3R) followed by almost complete retention of the ligand duplicates in most vertebrates but massive loss of receptor genes in tetrapods. Interestingly, the majority of 3R duplicates retained in teleosts are potentially involved in neuroendocrine regulation. Furthermore, we infer that the ancestral AncRxfp3/4 receptor may have been syntenically linked to the AncRln-like ligand in the pre-2R genome, and show that syntenic linkages among ligands and receptors have changed dynamically in different lineages. This study ultimately shows the broad utility, with some caveats, of incorporating paleogenomics data into understanding the evolution of gene families.
format	article
author	Sergey Yegorov Sara Good
author_facet	Sergey Yegorov Sara Good
author_sort	Sergey Yegorov
title	Using paleogenomics to study the evolution of gene families: origin and duplication history of the relaxin family hormones and their receptors.
title_short	Using paleogenomics to study the evolution of gene families: origin and duplication history of the relaxin family hormones and their receptors.
title_full	Using paleogenomics to study the evolution of gene families: origin and duplication history of the relaxin family hormones and their receptors.
title_fullStr	Using paleogenomics to study the evolution of gene families: origin and duplication history of the relaxin family hormones and their receptors.
title_full_unstemmed	Using paleogenomics to study the evolution of gene families: origin and duplication history of the relaxin family hormones and their receptors.
title_sort	using paleogenomics to study the evolution of gene families: origin and duplication history of the relaxin family hormones and their receptors.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/0141f9684e85438d996507fca25454c5
work_keys_str_mv	AT sergeyyegorov usingpaleogenomicstostudytheevolutionofgenefamiliesoriginandduplicationhistoryoftherelaxinfamilyhormonesandtheirreceptors AT saragood usingpaleogenomicstostudytheevolutionofgenefamiliesoriginandduplicationhistoryoftherelaxinfamilyhormonesandtheirreceptors
_version_	1718423451806466048

Using paleogenomics to study the evolution of gene families: origin and duplication history of the relaxin family hormones and their receptors.

Ejemplares similares