Multiple bouts of high-intensity interval exercise reverse age-related functional connectivity disruptions without affecting motor learning in older adults

Abstract Exercise has emerged as an intervention that may mitigate age-related resting state functional connectivity and sensorimotor decline. Here, 42 healthy older adults rested or completed 3 sets of high-intensity interval exercise for a total of 23 min, then immediately practiced an implicit mo...

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Autores principales:	Brian Greeley, Briana Chau, Christina B. Jones, Jason L. Neva, Sarah N. Kraeutner, Kristin L. Campbell, Lara A. Boyd
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0142745e1c344956bdf9ba433df2e176
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spelling	oai:doaj.org-article:0142745e1c344956bdf9ba433df2e1762021-12-02T16:35:11ZMultiple bouts of high-intensity interval exercise reverse age-related functional connectivity disruptions without affecting motor learning in older adults10.1038/s41598-021-96333-42045-2322https://doaj.org/article/0142745e1c344956bdf9ba433df2e1762021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96333-4https://doaj.org/toc/2045-2322Abstract Exercise has emerged as an intervention that may mitigate age-related resting state functional connectivity and sensorimotor decline. Here, 42 healthy older adults rested or completed 3 sets of high-intensity interval exercise for a total of 23 min, then immediately practiced an implicit motor task with their non-dominant hand across five separate sessions. Participants completed resting state functional MRI before the first and after the fifth day of practice; they also returned 24-h and 35-days later to assess short- and long-term retention. Independent component analysis of resting state functional MRI revealed increased connectivity in the frontoparietal, the dorsal attentional, and cerebellar networks in the exercise group relative to the rest group. Seed-based analysis showed strengthened connectivity between the limbic system and right cerebellum, and between the right cerebellum and bilateral middle temporal gyri in the exercise group. There was no motor learning advantage for the exercise group. Our data suggest that exercise paired with an implicit motor learning task in older adults can augment resting state functional connectivity without enhancing behaviour beyond that stimulated by skilled motor practice.Brian GreeleyBriana ChauChristina B. JonesJason L. NevaSarah N. KraeutnerKristin L. CampbellLara A. BoydNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Brian Greeley Briana Chau Christina B. Jones Jason L. Neva Sarah N. Kraeutner Kristin L. Campbell Lara A. Boyd Multiple bouts of high-intensity interval exercise reverse age-related functional connectivity disruptions without affecting motor learning in older adults
description	Abstract Exercise has emerged as an intervention that may mitigate age-related resting state functional connectivity and sensorimotor decline. Here, 42 healthy older adults rested or completed 3 sets of high-intensity interval exercise for a total of 23 min, then immediately practiced an implicit motor task with their non-dominant hand across five separate sessions. Participants completed resting state functional MRI before the first and after the fifth day of practice; they also returned 24-h and 35-days later to assess short- and long-term retention. Independent component analysis of resting state functional MRI revealed increased connectivity in the frontoparietal, the dorsal attentional, and cerebellar networks in the exercise group relative to the rest group. Seed-based analysis showed strengthened connectivity between the limbic system and right cerebellum, and between the right cerebellum and bilateral middle temporal gyri in the exercise group. There was no motor learning advantage for the exercise group. Our data suggest that exercise paired with an implicit motor learning task in older adults can augment resting state functional connectivity without enhancing behaviour beyond that stimulated by skilled motor practice.
format	article
author	Brian Greeley Briana Chau Christina B. Jones Jason L. Neva Sarah N. Kraeutner Kristin L. Campbell Lara A. Boyd
author_facet	Brian Greeley Briana Chau Christina B. Jones Jason L. Neva Sarah N. Kraeutner Kristin L. Campbell Lara A. Boyd
author_sort	Brian Greeley
title	Multiple bouts of high-intensity interval exercise reverse age-related functional connectivity disruptions without affecting motor learning in older adults
title_short	Multiple bouts of high-intensity interval exercise reverse age-related functional connectivity disruptions without affecting motor learning in older adults
title_full	Multiple bouts of high-intensity interval exercise reverse age-related functional connectivity disruptions without affecting motor learning in older adults
title_fullStr	Multiple bouts of high-intensity interval exercise reverse age-related functional connectivity disruptions without affecting motor learning in older adults
title_full_unstemmed	Multiple bouts of high-intensity interval exercise reverse age-related functional connectivity disruptions without affecting motor learning in older adults
title_sort	multiple bouts of high-intensity interval exercise reverse age-related functional connectivity disruptions without affecting motor learning in older adults
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0142745e1c344956bdf9ba433df2e176
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Multiple bouts of high-intensity interval exercise reverse age-related functional connectivity disruptions without affecting motor learning in older adults

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