Positive feedback regulation of p53 transactivity by DNA damage-induced ISG15 modification

The ‘genome guardian’ p53 has a well-established role in suppressing tumour development after DNA damage. Here the authors show that expression of the ubiquitin-like protein ISG15 is regulated by p53 which in turn is modified by ISG15 to enhance binding to target gene promoters.

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Autores principales: Jong Ho Park, Seung Wook Yang, Jung Mi Park, Seung Hyeun Ka, Ji-Hoon Kim, Young-Yun Kong, Young Joo Jeon, Jae Hong Seol, Chin Ha Chung
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/0144dff817294bd79c969b1960e74438
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spelling oai:doaj.org-article:0144dff817294bd79c969b1960e744382021-12-02T17:33:20ZPositive feedback regulation of p53 transactivity by DNA damage-induced ISG15 modification10.1038/ncomms125132041-1723https://doaj.org/article/0144dff817294bd79c969b1960e744382016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12513https://doaj.org/toc/2041-1723The ‘genome guardian’ p53 has a well-established role in suppressing tumour development after DNA damage. Here the authors show that expression of the ubiquitin-like protein ISG15 is regulated by p53 which in turn is modified by ISG15 to enhance binding to target gene promoters.Jong Ho ParkSeung Wook YangJung Mi ParkSeung Hyeun KaJi-Hoon KimYoung-Yun KongYoung Joo JeonJae Hong SeolChin Ha ChungNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jong Ho Park
Seung Wook Yang
Jung Mi Park
Seung Hyeun Ka
Ji-Hoon Kim
Young-Yun Kong
Young Joo Jeon
Jae Hong Seol
Chin Ha Chung
Positive feedback regulation of p53 transactivity by DNA damage-induced ISG15 modification
description The ‘genome guardian’ p53 has a well-established role in suppressing tumour development after DNA damage. Here the authors show that expression of the ubiquitin-like protein ISG15 is regulated by p53 which in turn is modified by ISG15 to enhance binding to target gene promoters.
format article
author Jong Ho Park
Seung Wook Yang
Jung Mi Park
Seung Hyeun Ka
Ji-Hoon Kim
Young-Yun Kong
Young Joo Jeon
Jae Hong Seol
Chin Ha Chung
author_facet Jong Ho Park
Seung Wook Yang
Jung Mi Park
Seung Hyeun Ka
Ji-Hoon Kim
Young-Yun Kong
Young Joo Jeon
Jae Hong Seol
Chin Ha Chung
author_sort Jong Ho Park
title Positive feedback regulation of p53 transactivity by DNA damage-induced ISG15 modification
title_short Positive feedback regulation of p53 transactivity by DNA damage-induced ISG15 modification
title_full Positive feedback regulation of p53 transactivity by DNA damage-induced ISG15 modification
title_fullStr Positive feedback regulation of p53 transactivity by DNA damage-induced ISG15 modification
title_full_unstemmed Positive feedback regulation of p53 transactivity by DNA damage-induced ISG15 modification
title_sort positive feedback regulation of p53 transactivity by dna damage-induced isg15 modification
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/0144dff817294bd79c969b1960e74438
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