Positive feedback regulation of p53 transactivity by DNA damage-induced ISG15 modification
The ‘genome guardian’ p53 has a well-established role in suppressing tumour development after DNA damage. Here the authors show that expression of the ubiquitin-like protein ISG15 is regulated by p53 which in turn is modified by ISG15 to enhance binding to target gene promoters.
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Nature Portfolio
2016
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oai:doaj.org-article:0144dff817294bd79c969b1960e744382021-12-02T17:33:20ZPositive feedback regulation of p53 transactivity by DNA damage-induced ISG15 modification10.1038/ncomms125132041-1723https://doaj.org/article/0144dff817294bd79c969b1960e744382016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12513https://doaj.org/toc/2041-1723The ‘genome guardian’ p53 has a well-established role in suppressing tumour development after DNA damage. Here the authors show that expression of the ubiquitin-like protein ISG15 is regulated by p53 which in turn is modified by ISG15 to enhance binding to target gene promoters.Jong Ho ParkSeung Wook YangJung Mi ParkSeung Hyeun KaJi-Hoon KimYoung-Yun KongYoung Joo JeonJae Hong SeolChin Ha ChungNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016) |
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Science Q Jong Ho Park Seung Wook Yang Jung Mi Park Seung Hyeun Ka Ji-Hoon Kim Young-Yun Kong Young Joo Jeon Jae Hong Seol Chin Ha Chung Positive feedback regulation of p53 transactivity by DNA damage-induced ISG15 modification |
description |
The ‘genome guardian’ p53 has a well-established role in suppressing tumour development after DNA damage. Here the authors show that expression of the ubiquitin-like protein ISG15 is regulated by p53 which in turn is modified by ISG15 to enhance binding to target gene promoters. |
format |
article |
author |
Jong Ho Park Seung Wook Yang Jung Mi Park Seung Hyeun Ka Ji-Hoon Kim Young-Yun Kong Young Joo Jeon Jae Hong Seol Chin Ha Chung |
author_facet |
Jong Ho Park Seung Wook Yang Jung Mi Park Seung Hyeun Ka Ji-Hoon Kim Young-Yun Kong Young Joo Jeon Jae Hong Seol Chin Ha Chung |
author_sort |
Jong Ho Park |
title |
Positive feedback regulation of p53 transactivity by DNA damage-induced ISG15 modification |
title_short |
Positive feedback regulation of p53 transactivity by DNA damage-induced ISG15 modification |
title_full |
Positive feedback regulation of p53 transactivity by DNA damage-induced ISG15 modification |
title_fullStr |
Positive feedback regulation of p53 transactivity by DNA damage-induced ISG15 modification |
title_full_unstemmed |
Positive feedback regulation of p53 transactivity by DNA damage-induced ISG15 modification |
title_sort |
positive feedback regulation of p53 transactivity by dna damage-induced isg15 modification |
publisher |
Nature Portfolio |
publishDate |
2016 |
url |
https://doaj.org/article/0144dff817294bd79c969b1960e74438 |
work_keys_str_mv |
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_version_ |
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