Positive feedback regulation of p53 transactivity by DNA damage-induced ISG15 modification

The ‘genome guardian’ p53 has a well-established role in suppressing tumour development after DNA damage. Here the authors show that expression of the ubiquitin-like protein ISG15 is regulated by p53 which in turn is modified by ISG15 to enhance binding to target gene promoters.

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Auteurs principaux:	Jong Ho Park, Seung Wook Yang, Jung Mi Park, Seung Hyeun Ka, Ji-Hoon Kim, Young-Yun Kong, Young Joo Jeon, Jae Hong Seol, Chin Ha Chung
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2016
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/0144dff817294bd79c969b1960e74438
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id	oai:doaj.org-article:0144dff817294bd79c969b1960e74438
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spelling	oai:doaj.org-article:0144dff817294bd79c969b1960e744382021-12-02T17:33:20ZPositive feedback regulation of p53 transactivity by DNA damage-induced ISG15 modification10.1038/ncomms125132041-1723https://doaj.org/article/0144dff817294bd79c969b1960e744382016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12513https://doaj.org/toc/2041-1723The ‘genome guardian’ p53 has a well-established role in suppressing tumour development after DNA damage. Here the authors show that expression of the ubiquitin-like protein ISG15 is regulated by p53 which in turn is modified by ISG15 to enhance binding to target gene promoters.Jong Ho ParkSeung Wook YangJung Mi ParkSeung Hyeun KaJi-Hoon KimYoung-Yun KongYoung Joo JeonJae Hong SeolChin Ha ChungNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jong Ho Park Seung Wook Yang Jung Mi Park Seung Hyeun Ka Ji-Hoon Kim Young-Yun Kong Young Joo Jeon Jae Hong Seol Chin Ha Chung Positive feedback regulation of p53 transactivity by DNA damage-induced ISG15 modification
description	The ‘genome guardian’ p53 has a well-established role in suppressing tumour development after DNA damage. Here the authors show that expression of the ubiquitin-like protein ISG15 is regulated by p53 which in turn is modified by ISG15 to enhance binding to target gene promoters.
format	article
author	Jong Ho Park Seung Wook Yang Jung Mi Park Seung Hyeun Ka Ji-Hoon Kim Young-Yun Kong Young Joo Jeon Jae Hong Seol Chin Ha Chung
author_facet	Jong Ho Park Seung Wook Yang Jung Mi Park Seung Hyeun Ka Ji-Hoon Kim Young-Yun Kong Young Joo Jeon Jae Hong Seol Chin Ha Chung
author_sort	Jong Ho Park
title	Positive feedback regulation of p53 transactivity by DNA damage-induced ISG15 modification
title_short	Positive feedback regulation of p53 transactivity by DNA damage-induced ISG15 modification
title_full	Positive feedback regulation of p53 transactivity by DNA damage-induced ISG15 modification
title_fullStr	Positive feedback regulation of p53 transactivity by DNA damage-induced ISG15 modification
title_full_unstemmed	Positive feedback regulation of p53 transactivity by DNA damage-induced ISG15 modification
title_sort	positive feedback regulation of p53 transactivity by dna damage-induced isg15 modification
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/0144dff817294bd79c969b1960e74438
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Positive feedback regulation of p53 transactivity by DNA damage-induced ISG15 modification

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