Positive feedback regulation of p53 transactivity by DNA damage-induced ISG15 modification

The ‘genome guardian’ p53 has a well-established role in suppressing tumour development after DNA damage. Here the authors show that expression of the ubiquitin-like protein ISG15 is regulated by p53 which in turn is modified by ISG15 to enhance binding to target gene promoters.

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Autores principales: Jong Ho Park, Seung Wook Yang, Jung Mi Park, Seung Hyeun Ka, Ji-Hoon Kim, Young-Yun Kong, Young Joo Jeon, Jae Hong Seol, Chin Ha Chung
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/0144dff817294bd79c969b1960e74438
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