Ginger from Farmyard to Town: Nutritional and Pharmacological Applications

Ginger (Zingiber officinale) is one of the most widely used natural products consumed as a spice and medicine for treating diabetes, flatulent intestinal colic, indigestion, infertility, inflammation, insomnia, a memory booster, nausea, rheumatism, stomach ache, and urinary tract infections. To date...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jeremiah Oshiomame Unuofin, Nelisiwe Prenate Masuku, Oluwatomiwa Kehinde Paimo, Sogolo Lucky Lebelo
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	ginger gingerols and shogaols nutritional composition in silico molecular docking studies clinical trials Zingiber officinale Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/01454f7faa044c798c09343fb436f4a6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:01454f7faa044c798c09343fb436f4a6
record_format	dspace
spelling	oai:doaj.org-article:01454f7faa044c798c09343fb436f4a62021-12-01T07:04:00ZGinger from Farmyard to Town: Nutritional and Pharmacological Applications1663-981210.3389/fphar.2021.779352https://doaj.org/article/01454f7faa044c798c09343fb436f4a62021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.779352/fullhttps://doaj.org/toc/1663-9812Ginger (Zingiber officinale) is one of the most widely used natural products consumed as a spice and medicine for treating diabetes, flatulent intestinal colic, indigestion, infertility, inflammation, insomnia, a memory booster, nausea, rheumatism, stomach ache, and urinary tract infections. To date, over 400 bioactive components, such as diarylheptanoids, gingerol analogues, phenylalkanoids, sulfonates, monoterpenoid glycosides, steroids, and terpene compounds have been derived from ginger. Increasing evidence has revealed that ginger possesses a broad range of biological activities, especially protective effects against male infertility, nausea and vomiting, analgesic, anti-diabetic, anti-inflammatory, anti-obesity, and other effects. The pharmacological activities of ginger were mainly attributed to its active phytoconstituents such as 6-gingerol, gingerdiol, gingerol, gingerdione, paradols, shogaols, sesquiterpenes, zingerone, besides other phenolics and flavonoids. In recent years, in silico molecular docking studies revealed that gingerol (6-gingerol, 8-gingerol, and 10-gingerol) and Shogaol (6-shogaol, 8-shogaol, 10-shogaol) had the best binding affinities to the receptor protein in disease conditions such as diabetes, inflammation, obesity, and SARS-CoV-2. Furthermore, some clinical trials have indicated that ginger can be consumed for alleviation of nausea and vomiting induced by surgery, pain, diabetes, obesity, inflammation, male infertility. This review provides an updated understanding of the scientific evidence on the development of ginger and its active compounds as health beneficial agents in future clinical trials.Jeremiah Oshiomame UnuofinNelisiwe Prenate MasukuOluwatomiwa Kehinde PaimoSogolo Lucky LebeloFrontiers Media S.A.articlegingergingerols and shogaolsnutritional compositionin silico molecular docking studiesclinical trialsZingiber officinaleTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ginger gingerols and shogaols nutritional composition in silico molecular docking studies clinical trials Zingiber officinale Therapeutics. Pharmacology RM1-950
spellingShingle	ginger gingerols and shogaols nutritional composition in silico molecular docking studies clinical trials Zingiber officinale Therapeutics. Pharmacology RM1-950 Jeremiah Oshiomame Unuofin Nelisiwe Prenate Masuku Oluwatomiwa Kehinde Paimo Sogolo Lucky Lebelo Ginger from Farmyard to Town: Nutritional and Pharmacological Applications
description	Ginger (Zingiber officinale) is one of the most widely used natural products consumed as a spice and medicine for treating diabetes, flatulent intestinal colic, indigestion, infertility, inflammation, insomnia, a memory booster, nausea, rheumatism, stomach ache, and urinary tract infections. To date, over 400 bioactive components, such as diarylheptanoids, gingerol analogues, phenylalkanoids, sulfonates, monoterpenoid glycosides, steroids, and terpene compounds have been derived from ginger. Increasing evidence has revealed that ginger possesses a broad range of biological activities, especially protective effects against male infertility, nausea and vomiting, analgesic, anti-diabetic, anti-inflammatory, anti-obesity, and other effects. The pharmacological activities of ginger were mainly attributed to its active phytoconstituents such as 6-gingerol, gingerdiol, gingerol, gingerdione, paradols, shogaols, sesquiterpenes, zingerone, besides other phenolics and flavonoids. In recent years, in silico molecular docking studies revealed that gingerol (6-gingerol, 8-gingerol, and 10-gingerol) and Shogaol (6-shogaol, 8-shogaol, 10-shogaol) had the best binding affinities to the receptor protein in disease conditions such as diabetes, inflammation, obesity, and SARS-CoV-2. Furthermore, some clinical trials have indicated that ginger can be consumed for alleviation of nausea and vomiting induced by surgery, pain, diabetes, obesity, inflammation, male infertility. This review provides an updated understanding of the scientific evidence on the development of ginger and its active compounds as health beneficial agents in future clinical trials.
format	article
author	Jeremiah Oshiomame Unuofin Nelisiwe Prenate Masuku Oluwatomiwa Kehinde Paimo Sogolo Lucky Lebelo
author_facet	Jeremiah Oshiomame Unuofin Nelisiwe Prenate Masuku Oluwatomiwa Kehinde Paimo Sogolo Lucky Lebelo
author_sort	Jeremiah Oshiomame Unuofin
title	Ginger from Farmyard to Town: Nutritional and Pharmacological Applications
title_short	Ginger from Farmyard to Town: Nutritional and Pharmacological Applications
title_full	Ginger from Farmyard to Town: Nutritional and Pharmacological Applications
title_fullStr	Ginger from Farmyard to Town: Nutritional and Pharmacological Applications
title_full_unstemmed	Ginger from Farmyard to Town: Nutritional and Pharmacological Applications
title_sort	ginger from farmyard to town: nutritional and pharmacological applications
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/01454f7faa044c798c09343fb436f4a6
work_keys_str_mv	AT jeremiahoshiomameunuofin gingerfromfarmyardtotownnutritionalandpharmacologicalapplications AT nelisiweprenatemasuku gingerfromfarmyardtotownnutritionalandpharmacologicalapplications AT oluwatomiwakehindepaimo gingerfromfarmyardtotownnutritionalandpharmacologicalapplications AT sogololuckylebelo gingerfromfarmyardtotownnutritionalandpharmacologicalapplications
_version_	1718405394069454848

Ginger from Farmyard to Town: Nutritional and Pharmacological Applications

Ejemplares similares