Effects of Post-natal Dietary Milk Fat Globule Membrane Polar Lipid Supplementation on Motor Skills, Anxiety, and Long-Term Memory in Adulthood

Early life nutrition critically impacts post-natal brain maturation and cognitive development. Post-natal dietary deficits in specific nutrients, such as lipids, minerals or vitamins are associated with brain maturation and cognitive impairments. Specifically, polar lipids (PL), such as sphingolipid...

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Autores principales:	Sébastien Sultan, Jonas Hauser, Manuel Oliveira, Andreas Rytz, Nicolas Preitner, Nora Schneider
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	neurodevelopment nutrition polar lipids learning memory Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/014696dc33294281bbcc8faaf294b346
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spelling	oai:doaj.org-article:014696dc33294281bbcc8faaf294b3462021-11-16T07:48:55ZEffects of Post-natal Dietary Milk Fat Globule Membrane Polar Lipid Supplementation on Motor Skills, Anxiety, and Long-Term Memory in Adulthood2296-861X10.3389/fnut.2021.737731https://doaj.org/article/014696dc33294281bbcc8faaf294b3462021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnut.2021.737731/fullhttps://doaj.org/toc/2296-861XEarly life nutrition critically impacts post-natal brain maturation and cognitive development. Post-natal dietary deficits in specific nutrients, such as lipids, minerals or vitamins are associated with brain maturation and cognitive impairments. Specifically, polar lipids (PL), such as sphingolipids and phospholipids, are important cellular membrane building blocks and are critical for brain connectivity due to their role in neurite outgrowth, synaptic formation, and myelination. In this preclinical study, we assessed the effects of a chronic supplementation with a source of PL extracted from an alpha-lactalbumin enriched whey protein containing 10% lipids from early life (post-natal day (PND) 7) to adulthood (PND 72) on adult motor skills, anxiety, and long-term memory. The motor skills were assessed using open field and rotarod test. Anxiety was assessed using elevated plus maze (EPM). Long-term object and spatial memory were assessed using novel object recognition (NOR) and Morris water maze (MWM). Our results suggest that chronic PL supplementation improved measures of spatial long-term memory accuracy and cognitive flexibility in the MWM in adulthood, with no change in general mobility, anxiety and exploratory behavior. Our results indicate memory specific functional benefits of long-term dietary PL during post-natal brain development.Sébastien SultanJonas HauserManuel OliveiraAndreas RytzNicolas PreitnerNora SchneiderFrontiers Media S.A.articleneurodevelopmentnutritionpolar lipidslearningmemoryNutrition. Foods and food supplyTX341-641ENFrontiers in Nutrition, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	neurodevelopment nutrition polar lipids learning memory Nutrition. Foods and food supply TX341-641
spellingShingle	neurodevelopment nutrition polar lipids learning memory Nutrition. Foods and food supply TX341-641 Sébastien Sultan Jonas Hauser Manuel Oliveira Andreas Rytz Nicolas Preitner Nora Schneider Effects of Post-natal Dietary Milk Fat Globule Membrane Polar Lipid Supplementation on Motor Skills, Anxiety, and Long-Term Memory in Adulthood
description	Early life nutrition critically impacts post-natal brain maturation and cognitive development. Post-natal dietary deficits in specific nutrients, such as lipids, minerals or vitamins are associated with brain maturation and cognitive impairments. Specifically, polar lipids (PL), such as sphingolipids and phospholipids, are important cellular membrane building blocks and are critical for brain connectivity due to their role in neurite outgrowth, synaptic formation, and myelination. In this preclinical study, we assessed the effects of a chronic supplementation with a source of PL extracted from an alpha-lactalbumin enriched whey protein containing 10% lipids from early life (post-natal day (PND) 7) to adulthood (PND 72) on adult motor skills, anxiety, and long-term memory. The motor skills were assessed using open field and rotarod test. Anxiety was assessed using elevated plus maze (EPM). Long-term object and spatial memory were assessed using novel object recognition (NOR) and Morris water maze (MWM). Our results suggest that chronic PL supplementation improved measures of spatial long-term memory accuracy and cognitive flexibility in the MWM in adulthood, with no change in general mobility, anxiety and exploratory behavior. Our results indicate memory specific functional benefits of long-term dietary PL during post-natal brain development.
format	article
author	Sébastien Sultan Jonas Hauser Manuel Oliveira Andreas Rytz Nicolas Preitner Nora Schneider
author_facet	Sébastien Sultan Jonas Hauser Manuel Oliveira Andreas Rytz Nicolas Preitner Nora Schneider
author_sort	Sébastien Sultan
title	Effects of Post-natal Dietary Milk Fat Globule Membrane Polar Lipid Supplementation on Motor Skills, Anxiety, and Long-Term Memory in Adulthood
title_short	Effects of Post-natal Dietary Milk Fat Globule Membrane Polar Lipid Supplementation on Motor Skills, Anxiety, and Long-Term Memory in Adulthood
title_full	Effects of Post-natal Dietary Milk Fat Globule Membrane Polar Lipid Supplementation on Motor Skills, Anxiety, and Long-Term Memory in Adulthood
title_fullStr	Effects of Post-natal Dietary Milk Fat Globule Membrane Polar Lipid Supplementation on Motor Skills, Anxiety, and Long-Term Memory in Adulthood
title_full_unstemmed	Effects of Post-natal Dietary Milk Fat Globule Membrane Polar Lipid Supplementation on Motor Skills, Anxiety, and Long-Term Memory in Adulthood
title_sort	effects of post-natal dietary milk fat globule membrane polar lipid supplementation on motor skills, anxiety, and long-term memory in adulthood
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/014696dc33294281bbcc8faaf294b346
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Effects of Post-natal Dietary Milk Fat Globule Membrane Polar Lipid Supplementation on Motor Skills, Anxiety, and Long-Term Memory in Adulthood

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