Population epidemiology and concordance for plasma amino acids and precursors in 11–12-year-old children and their parents

Abstract Amino acid (AA) concentrations are influenced by both exogenous (e.g. diet, lifestyle) and endogenous factors (e.g. genetic, transcriptomic, epigenetic, and metabolomic). Fasting plasma AA profiles in adulthood are predictive of diabetes risk over periods of up to 12 years. Data on AA profi...

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Autores principales:	Stephanie Andraos, Katherine Lange, Susan A. Clifford, Beatrix Jones, Eric B. Thorstensen, Melissa Wake, David P. Burgner, Richard Saffery, Justin M. O’Sullivan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0146d7ed09fb45ccaad940b47304c289
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spelling	oai:doaj.org-article:0146d7ed09fb45ccaad940b47304c2892021-12-02T14:11:30ZPopulation epidemiology and concordance for plasma amino acids and precursors in 11–12-year-old children and their parents10.1038/s41598-020-80923-92045-2322https://doaj.org/article/0146d7ed09fb45ccaad940b47304c2892021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80923-9https://doaj.org/toc/2045-2322Abstract Amino acid (AA) concentrations are influenced by both exogenous (e.g. diet, lifestyle) and endogenous factors (e.g. genetic, transcriptomic, epigenetic, and metabolomic). Fasting plasma AA profiles in adulthood are predictive of diabetes risk over periods of up to 12 years. Data on AA profiles in cross-generational cohorts, including individuals from shared gene-environment settings are scarce, but would allow the identification of the contribution of heritable and environmental factors characterising the levels of circulating AAs. This study aimed to investigate parent–child (familial dyad) concordance, absolute differences between generations- (children versus adults), age- (in adults: 28–71 years), and sex-dependent differences in plasma AA concentrations. Plasma AA concentrations were measured by UHPLC/MS–MS in 1166 children [mean (SD) age 11 (0.5) years, 51% female] and 1324 of their parents [44 (5.1) years, 87% female]. AA concentrations were variably concordant between parents and their children (5–41% of variability explained). Most AA concentrations were higher in adults than children, except for the non-essential AAs arginine, aspartic acid, glutamine, hydroxy-proline, proline, and serine. Male adults and children typically had higher AA concentrations than females. The exceptions were alanine, glutamine, glycine, hydroxy-proline, serine, and threonine in girls; and glycine and serine in women. Age, sex, and shared familial factors are important determinants of plasma AA concentrations.Stephanie AndraosKatherine LangeSusan A. CliffordBeatrix JonesEric B. ThorstensenMelissa WakeDavid P. BurgnerRichard SafferyJustin M. O’SullivanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Stephanie Andraos Katherine Lange Susan A. Clifford Beatrix Jones Eric B. Thorstensen Melissa Wake David P. Burgner Richard Saffery Justin M. O’Sullivan Population epidemiology and concordance for plasma amino acids and precursors in 11–12-year-old children and their parents
description	Abstract Amino acid (AA) concentrations are influenced by both exogenous (e.g. diet, lifestyle) and endogenous factors (e.g. genetic, transcriptomic, epigenetic, and metabolomic). Fasting plasma AA profiles in adulthood are predictive of diabetes risk over periods of up to 12 years. Data on AA profiles in cross-generational cohorts, including individuals from shared gene-environment settings are scarce, but would allow the identification of the contribution of heritable and environmental factors characterising the levels of circulating AAs. This study aimed to investigate parent–child (familial dyad) concordance, absolute differences between generations- (children versus adults), age- (in adults: 28–71 years), and sex-dependent differences in plasma AA concentrations. Plasma AA concentrations were measured by UHPLC/MS–MS in 1166 children [mean (SD) age 11 (0.5) years, 51% female] and 1324 of their parents [44 (5.1) years, 87% female]. AA concentrations were variably concordant between parents and their children (5–41% of variability explained). Most AA concentrations were higher in adults than children, except for the non-essential AAs arginine, aspartic acid, glutamine, hydroxy-proline, proline, and serine. Male adults and children typically had higher AA concentrations than females. The exceptions were alanine, glutamine, glycine, hydroxy-proline, serine, and threonine in girls; and glycine and serine in women. Age, sex, and shared familial factors are important determinants of plasma AA concentrations.
format	article
author	Stephanie Andraos Katherine Lange Susan A. Clifford Beatrix Jones Eric B. Thorstensen Melissa Wake David P. Burgner Richard Saffery Justin M. O’Sullivan
author_facet	Stephanie Andraos Katherine Lange Susan A. Clifford Beatrix Jones Eric B. Thorstensen Melissa Wake David P. Burgner Richard Saffery Justin M. O’Sullivan
author_sort	Stephanie Andraos
title	Population epidemiology and concordance for plasma amino acids and precursors in 11–12-year-old children and their parents
title_short	Population epidemiology and concordance for plasma amino acids and precursors in 11–12-year-old children and their parents
title_full	Population epidemiology and concordance for plasma amino acids and precursors in 11–12-year-old children and their parents
title_fullStr	Population epidemiology and concordance for plasma amino acids and precursors in 11–12-year-old children and their parents
title_full_unstemmed	Population epidemiology and concordance for plasma amino acids and precursors in 11–12-year-old children and their parents
title_sort	population epidemiology and concordance for plasma amino acids and precursors in 11–12-year-old children and their parents
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0146d7ed09fb45ccaad940b47304c289
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Population epidemiology and concordance for plasma amino acids and precursors in 11–12-year-old children and their parents

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