An Overview: The Toxicity of Ageratina adenophora on Animals and Its Possible Interventions

Ageratina adenophora is one of the major invasive weeds that causes instability of the ecosystem. Research has reported that A. adenophora produces allelochemicals that inhibit the growth and development of food crops, and also contain some toxic compounds that...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Zhihua Ren, Samuel Kumi Okyere, Juan Wen, Lei Xie, Yujing Cui, Shu Wang, Jianchen Wang, Suizhong Cao, Liuhong Shen, Xiaoping Ma, Shumin Yu, Junliang Deng, Yanchun Hu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Ageratina adenophora</i> toxicity mechanisms possible interventions antioxidant anti-inflammation Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/0146efe86ef0479a847c896659d258f8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0146efe86ef0479a847c896659d258f8
record_format	dspace
spelling	oai:doaj.org-article:0146efe86ef0479a847c896659d258f82021-11-11T17:03:51ZAn Overview: The Toxicity of <i>Ageratina adenophora</i> on Animals and Its Possible Interventions10.3390/ijms2221115811422-00671661-6596https://doaj.org/article/0146efe86ef0479a847c896659d258f82021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11581https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067<i>Ageratina adenophora</i> is one of the major invasive weeds that causes instability of the ecosystem. Research has reported that <i>A. adenophora</i> produces allelochemicals that inhibit the growth and development of food crops, and also contain some toxic compounds that cause toxicity to animals that consume it. Over the past decades, studies on the identification of major toxic compounds of <i>A. adenophora</i> and their toxic molecular mechanisms have been reported. In addition, weed control interventions, such as herbicides application, was employed to reduce the spread of <i>A. adenophora</i>. However, the development of therapeutic and prophylactic measures to treat the various <i>A. adenophora</i>—induced toxicities, such as hepatotoxicity, splenotoxicity and other related disorders, have not been established to date. The main toxic pathogenesis of <i>A. adenophora</i> is oxidative stress and inflammation. However, numerous studies have verified that some extracts and secondary metabolites isolated from <i>A. adenophora</i> possess anti-oxidation and anti-inflammation activities, which implies that these extracts can relieve toxicity and aid in the development of drug or feed supplements to treat poisoning-related disorders caused by <i>A. adenophora</i>. Furthermore, beneficial bacteria isolated from rumen microbes and <i>A. adenophora</i> can degrade major toxic compounds in <i>A. adenophora</i> so as to be developed into microbial feed additives to help ameliorate toxicity mediated by <i>A. adenophora</i>. This review presents an overview of the toxic mechanisms of <i>A. adenophora</i>, provides possible therapeutic strategies that are available to mitigate the toxicity of <i>A. adenophora</i> and introduces relevant information on identifying novel prophylactic and therapeutic measures against <i>A. adenophora</i>—induced toxicity.Zhihua RenSamuel Kumi OkyereJuan WenLei XieYujing CuiShu WangJianchen WangSuizhong CaoLiuhong ShenXiaoping MaShumin YuJunliang DengYanchun HuMDPI AGarticle<i>Ageratina adenophora</i>toxicitymechanismspossible interventionsantioxidantanti-inflammationBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11581, p 11581 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Ageratina adenophora</i> toxicity mechanisms possible interventions antioxidant anti-inflammation Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	<i>Ageratina adenophora</i> toxicity mechanisms possible interventions antioxidant anti-inflammation Biology (General) QH301-705.5 Chemistry QD1-999 Zhihua Ren Samuel Kumi Okyere Juan Wen Lei Xie Yujing Cui Shu Wang Jianchen Wang Suizhong Cao Liuhong Shen Xiaoping Ma Shumin Yu Junliang Deng Yanchun Hu An Overview: The Toxicity of <i>Ageratina adenophora</i> on Animals and Its Possible Interventions
description	<i>Ageratina adenophora</i> is one of the major invasive weeds that causes instability of the ecosystem. Research has reported that <i>A. adenophora</i> produces allelochemicals that inhibit the growth and development of food crops, and also contain some toxic compounds that cause toxicity to animals that consume it. Over the past decades, studies on the identification of major toxic compounds of <i>A. adenophora</i> and their toxic molecular mechanisms have been reported. In addition, weed control interventions, such as herbicides application, was employed to reduce the spread of <i>A. adenophora</i>. However, the development of therapeutic and prophylactic measures to treat the various <i>A. adenophora</i>—induced toxicities, such as hepatotoxicity, splenotoxicity and other related disorders, have not been established to date. The main toxic pathogenesis of <i>A. adenophora</i> is oxidative stress and inflammation. However, numerous studies have verified that some extracts and secondary metabolites isolated from <i>A. adenophora</i> possess anti-oxidation and anti-inflammation activities, which implies that these extracts can relieve toxicity and aid in the development of drug or feed supplements to treat poisoning-related disorders caused by <i>A. adenophora</i>. Furthermore, beneficial bacteria isolated from rumen microbes and <i>A. adenophora</i> can degrade major toxic compounds in <i>A. adenophora</i> so as to be developed into microbial feed additives to help ameliorate toxicity mediated by <i>A. adenophora</i>. This review presents an overview of the toxic mechanisms of <i>A. adenophora</i>, provides possible therapeutic strategies that are available to mitigate the toxicity of <i>A. adenophora</i> and introduces relevant information on identifying novel prophylactic and therapeutic measures against <i>A. adenophora</i>—induced toxicity.
format	article
author	Zhihua Ren Samuel Kumi Okyere Juan Wen Lei Xie Yujing Cui Shu Wang Jianchen Wang Suizhong Cao Liuhong Shen Xiaoping Ma Shumin Yu Junliang Deng Yanchun Hu
author_facet	Zhihua Ren Samuel Kumi Okyere Juan Wen Lei Xie Yujing Cui Shu Wang Jianchen Wang Suizhong Cao Liuhong Shen Xiaoping Ma Shumin Yu Junliang Deng Yanchun Hu
author_sort	Zhihua Ren
title	An Overview: The Toxicity of <i>Ageratina adenophora</i> on Animals and Its Possible Interventions
title_short	An Overview: The Toxicity of <i>Ageratina adenophora</i> on Animals and Its Possible Interventions
title_full	An Overview: The Toxicity of <i>Ageratina adenophora</i> on Animals and Its Possible Interventions
title_fullStr	An Overview: The Toxicity of <i>Ageratina adenophora</i> on Animals and Its Possible Interventions
title_full_unstemmed	An Overview: The Toxicity of <i>Ageratina adenophora</i> on Animals and Its Possible Interventions
title_sort	overview: the toxicity of <i>ageratina adenophora</i> on animals and its possible interventions
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/0146efe86ef0479a847c896659d258f8
work_keys_str_mv	AT zhihuaren anoverviewthetoxicityofiageratinaadenophoraionanimalsanditspossibleinterventions AT samuelkumiokyere anoverviewthetoxicityofiageratinaadenophoraionanimalsanditspossibleinterventions AT juanwen anoverviewthetoxicityofiageratinaadenophoraionanimalsanditspossibleinterventions AT leixie anoverviewthetoxicityofiageratinaadenophoraionanimalsanditspossibleinterventions AT yujingcui anoverviewthetoxicityofiageratinaadenophoraionanimalsanditspossibleinterventions AT shuwang anoverviewthetoxicityofiageratinaadenophoraionanimalsanditspossibleinterventions AT jianchenwang anoverviewthetoxicityofiageratinaadenophoraionanimalsanditspossibleinterventions AT suizhongcao anoverviewthetoxicityofiageratinaadenophoraionanimalsanditspossibleinterventions AT liuhongshen anoverviewthetoxicityofiageratinaadenophoraionanimalsanditspossibleinterventions AT xiaopingma anoverviewthetoxicityofiageratinaadenophoraionanimalsanditspossibleinterventions AT shuminyu anoverviewthetoxicityofiageratinaadenophoraionanimalsanditspossibleinterventions AT junliangdeng anoverviewthetoxicityofiageratinaadenophoraionanimalsanditspossibleinterventions AT yanchunhu anoverviewthetoxicityofiageratinaadenophoraionanimalsanditspossibleinterventions AT zhihuaren overviewthetoxicityofiageratinaadenophoraionanimalsanditspossibleinterventions AT samuelkumiokyere overviewthetoxicityofiageratinaadenophoraionanimalsanditspossibleinterventions AT juanwen overviewthetoxicityofiageratinaadenophoraionanimalsanditspossibleinterventions AT leixie overviewthetoxicityofiageratinaadenophoraionanimalsanditspossibleinterventions AT yujingcui overviewthetoxicityofiageratinaadenophoraionanimalsanditspossibleinterventions AT shuwang overviewthetoxicityofiageratinaadenophoraionanimalsanditspossibleinterventions AT jianchenwang overviewthetoxicityofiageratinaadenophoraionanimalsanditspossibleinterventions AT suizhongcao overviewthetoxicityofiageratinaadenophoraionanimalsanditspossibleinterventions AT liuhongshen overviewthetoxicityofiageratinaadenophoraionanimalsanditspossibleinterventions AT xiaopingma overviewthetoxicityofiageratinaadenophoraionanimalsanditspossibleinterventions AT shuminyu overviewthetoxicityofiageratinaadenophoraionanimalsanditspossibleinterventions AT junliangdeng overviewthetoxicityofiageratinaadenophoraionanimalsanditspossibleinterventions AT yanchunhu overviewthetoxicityofiageratinaadenophoraionanimalsanditspossibleinterventions
_version_	1718432158458052608

An Overview: The Toxicity of <i>Ageratina adenophora</i> on Animals and Its Possible Interventions

Ejemplares similares