Prokineticin-2 prevents neuronal cell deaths in a model of traumatic brain injury

Prokineticin-2 prevents neuronal cell deaths in a model of traumatic brain injury

Prokineticin-2 (Prok2) is a secreted protein involved in many physiological processes. Here, the authors show that Prok2 prevents neuronal cell ferroptosis after traumatic brain injury and its administration before cortical injury reduces neuronal degeneration, and motor and cognitive impairments.

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Auteurs principaux: Zhongyuan Bao, Yinlong Liu, Binglin Chen, Zong Miao, Yiming Tu, Chong Li, Honglu Chao, Yangfan Ye, Xiupeng Xu, Guangchi Sun, Pengzhan Zhao, Ning Liu, Yan Liu, Xiaoming Wang, Sin Man Lam, Valerian E. Kagan, Hülya Bayır, Jing Ji
Format: article
Langue:EN
Publié: Nature Portfolio 2021
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Science
Q
Accès en ligne:https://doaj.org/article/014cfde24f7647fc8390c531c4a06ca5
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Résumé:Prokineticin-2 (Prok2) is a secreted protein involved in many physiological processes. Here, the authors show that Prok2 prevents neuronal cell ferroptosis after traumatic brain injury and its administration before cortical injury reduces neuronal degeneration, and motor and cognitive impairments.

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