Prokineticin-2 prevents neuronal cell deaths in a model of traumatic brain injury

Prokineticin-2 (Prok2) is a secreted protein involved in many physiological processes. Here, the authors show that Prok2 prevents neuronal cell ferroptosis after traumatic brain injury and its administration before cortical injury reduces neuronal degeneration, and motor and cognitive impairments.

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Autores principales:	Zhongyuan Bao, Yinlong Liu, Binglin Chen, Zong Miao, Yiming Tu, Chong Li, Honglu Chao, Yangfan Ye, Xiupeng Xu, Guangchi Sun, Pengzhan Zhao, Ning Liu, Yan Liu, Xiaoming Wang, Sin Man Lam, Valerian E. Kagan, Hülya Bayır, Jing Ji
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/014cfde24f7647fc8390c531c4a06ca5
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spelling	oai:doaj.org-article:014cfde24f7647fc8390c531c4a06ca52021-12-02T15:39:42ZProkineticin-2 prevents neuronal cell deaths in a model of traumatic brain injury10.1038/s41467-021-24469-y2041-1723https://doaj.org/article/014cfde24f7647fc8390c531c4a06ca52021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24469-yhttps://doaj.org/toc/2041-1723Prokineticin-2 (Prok2) is a secreted protein involved in many physiological processes. Here, the authors show that Prok2 prevents neuronal cell ferroptosis after traumatic brain injury and its administration before cortical injury reduces neuronal degeneration, and motor and cognitive impairments.Zhongyuan BaoYinlong LiuBinglin ChenZong MiaoYiming TuChong LiHonglu ChaoYangfan YeXiupeng XuGuangchi SunPengzhan ZhaoNing LiuYan LiuXiaoming WangSin Man LamValerian E. KaganHülya BayırJing JiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhongyuan Bao Yinlong Liu Binglin Chen Zong Miao Yiming Tu Chong Li Honglu Chao Yangfan Ye Xiupeng Xu Guangchi Sun Pengzhan Zhao Ning Liu Yan Liu Xiaoming Wang Sin Man Lam Valerian E. Kagan Hülya Bayır Jing Ji Prokineticin-2 prevents neuronal cell deaths in a model of traumatic brain injury
description	Prokineticin-2 (Prok2) is a secreted protein involved in many physiological processes. Here, the authors show that Prok2 prevents neuronal cell ferroptosis after traumatic brain injury and its administration before cortical injury reduces neuronal degeneration, and motor and cognitive impairments.
format	article
author	Zhongyuan Bao Yinlong Liu Binglin Chen Zong Miao Yiming Tu Chong Li Honglu Chao Yangfan Ye Xiupeng Xu Guangchi Sun Pengzhan Zhao Ning Liu Yan Liu Xiaoming Wang Sin Man Lam Valerian E. Kagan Hülya Bayır Jing Ji
author_facet	Zhongyuan Bao Yinlong Liu Binglin Chen Zong Miao Yiming Tu Chong Li Honglu Chao Yangfan Ye Xiupeng Xu Guangchi Sun Pengzhan Zhao Ning Liu Yan Liu Xiaoming Wang Sin Man Lam Valerian E. Kagan Hülya Bayır Jing Ji
author_sort	Zhongyuan Bao
title	Prokineticin-2 prevents neuronal cell deaths in a model of traumatic brain injury
title_short	Prokineticin-2 prevents neuronal cell deaths in a model of traumatic brain injury
title_full	Prokineticin-2 prevents neuronal cell deaths in a model of traumatic brain injury
title_fullStr	Prokineticin-2 prevents neuronal cell deaths in a model of traumatic brain injury
title_full_unstemmed	Prokineticin-2 prevents neuronal cell deaths in a model of traumatic brain injury
title_sort	prokineticin-2 prevents neuronal cell deaths in a model of traumatic brain injury
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/014cfde24f7647fc8390c531c4a06ca5
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Prokineticin-2 prevents neuronal cell deaths in a model of traumatic brain injury

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