EVALUATION OF CLINICAL AND LABORATORY CHARACTERISTICS OF CHILDREN WITH RHABDOID TUMOR: A MULTICENTER STUDY

Objective: Rhabdoid tumors, which are rare in childhood, are aggressive cancers. It can be particularly seen in 3 different anatomical regions, mostly in the central nervous system, kidneys, and soft tissue in early childhood. In this study, it was aimed to evaluate the clinical, radiological and pa...

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Autores principales:	Firdevs AYDIN, Kemal DENİZ, Süreyya Burcu GÖRKEM, Veysel GÖK, Alper ÖZCAN, Ebru YILMAZ, Ekrem ÜNAL, Musa KARAKÜKÇÜ, Türkan PATIROĞLU, Mehmet Akif ÖZDEMİR, Can ACIPAYAM, Defne AY TUNCEL
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Diseases of the blood and blood-forming organs RC633-647.5
Acceso en línea:	https://doaj.org/article/0154714528984f74b8b6314ef38cda86
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spelling	oai:doaj.org-article:0154714528984f74b8b6314ef38cda862021-11-10T04:34:23ZEVALUATION OF CLINICAL AND LABORATORY CHARACTERISTICS OF CHILDREN WITH RHABDOID TUMOR: A MULTICENTER STUDY2531-137910.1016/j.htct.2021.10.1008https://doaj.org/article/0154714528984f74b8b6314ef38cda862021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S253113792101155Xhttps://doaj.org/toc/2531-1379Objective: Rhabdoid tumors, which are rare in childhood, are aggressive cancers. It can be particularly seen in 3 different anatomical regions, mostly in the central nervous system, kidneys, and soft tissue in early childhood. In this study, it was aimed to evaluate the clinical, radiological and pathological features of pediatric patients with rhabdoid tumors who were followed up and treated in 3 different pediatric oncology reference centers. Methodology: Erciyes University Faculty of Medicine, Kahramanmaraş Sütçü İmam University Faculty of Medicine, Health Practice and Research Hospital and Adana City Training and Research Hospital, 17 patients diagnosed with rhabdoid tumor between 2002-2021 were retrospectively analyzed. Results: Of the patients, 6 (35%) were female and 11 (65%) were male. Chemotherapy (Doxorubicin, Ifosfamide, Carboplatinum, Etoposide, Vincristine, Actinomycin-D, Cyclophosphamide) was administered to the patients at different times. Radiotherapy was applied to 8 (47%) of the patients. The tumor was in the brain in 8 (47%) of the patients, in the kidney in 4 (23%), in the skin in 4 (23%), and the liver in 1 (6%). Conclusion: In this study, the incidence of rhabdoid tumors was higher in males. This may be due to the small number of cases. The 2 years overall survival rates were 50% in brain tumors, 6% in kidney tumors, and 12% in others, according to tumor localization. The localization and stage of the tumor were determinants of the survival of the patients. More clinical studies are needed to improve survival and identify more effective treatment strategies in these tumors.Firdevs AYDINKemal DENİZSüreyya Burcu GÖRKEMVeysel GÖKAlper ÖZCANEbru YILMAZEkrem ÜNALMusa KARAKÜKÇÜTürkan PATIROĞLUMehmet Akif ÖZDEMİRCan ACIPAYAMDefne AY TUNCELElsevierarticleDiseases of the blood and blood-forming organsRC633-647.5ENHematology, Transfusion and Cell Therapy, Vol 43, Iss , Pp S31- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the blood and blood-forming organs RC633-647.5
spellingShingle	Diseases of the blood and blood-forming organs RC633-647.5 Firdevs AYDIN Kemal DENİZ Süreyya Burcu GÖRKEM Veysel GÖK Alper ÖZCAN Ebru YILMAZ Ekrem ÜNAL Musa KARAKÜKÇÜ Türkan PATIROĞLU Mehmet Akif ÖZDEMİR Can ACIPAYAM Defne AY TUNCEL EVALUATION OF CLINICAL AND LABORATORY CHARACTERISTICS OF CHILDREN WITH RHABDOID TUMOR: A MULTICENTER STUDY
description	Objective: Rhabdoid tumors, which are rare in childhood, are aggressive cancers. It can be particularly seen in 3 different anatomical regions, mostly in the central nervous system, kidneys, and soft tissue in early childhood. In this study, it was aimed to evaluate the clinical, radiological and pathological features of pediatric patients with rhabdoid tumors who were followed up and treated in 3 different pediatric oncology reference centers. Methodology: Erciyes University Faculty of Medicine, Kahramanmaraş Sütçü İmam University Faculty of Medicine, Health Practice and Research Hospital and Adana City Training and Research Hospital, 17 patients diagnosed with rhabdoid tumor between 2002-2021 were retrospectively analyzed. Results: Of the patients, 6 (35%) were female and 11 (65%) were male. Chemotherapy (Doxorubicin, Ifosfamide, Carboplatinum, Etoposide, Vincristine, Actinomycin-D, Cyclophosphamide) was administered to the patients at different times. Radiotherapy was applied to 8 (47%) of the patients. The tumor was in the brain in 8 (47%) of the patients, in the kidney in 4 (23%), in the skin in 4 (23%), and the liver in 1 (6%). Conclusion: In this study, the incidence of rhabdoid tumors was higher in males. This may be due to the small number of cases. The 2 years overall survival rates were 50% in brain tumors, 6% in kidney tumors, and 12% in others, according to tumor localization. The localization and stage of the tumor were determinants of the survival of the patients. More clinical studies are needed to improve survival and identify more effective treatment strategies in these tumors.
format	article
author	Firdevs AYDIN Kemal DENİZ Süreyya Burcu GÖRKEM Veysel GÖK Alper ÖZCAN Ebru YILMAZ Ekrem ÜNAL Musa KARAKÜKÇÜ Türkan PATIROĞLU Mehmet Akif ÖZDEMİR Can ACIPAYAM Defne AY TUNCEL
author_facet	Firdevs AYDIN Kemal DENİZ Süreyya Burcu GÖRKEM Veysel GÖK Alper ÖZCAN Ebru YILMAZ Ekrem ÜNAL Musa KARAKÜKÇÜ Türkan PATIROĞLU Mehmet Akif ÖZDEMİR Can ACIPAYAM Defne AY TUNCEL
author_sort	Firdevs AYDIN
title	EVALUATION OF CLINICAL AND LABORATORY CHARACTERISTICS OF CHILDREN WITH RHABDOID TUMOR: A MULTICENTER STUDY
title_short	EVALUATION OF CLINICAL AND LABORATORY CHARACTERISTICS OF CHILDREN WITH RHABDOID TUMOR: A MULTICENTER STUDY
title_full	EVALUATION OF CLINICAL AND LABORATORY CHARACTERISTICS OF CHILDREN WITH RHABDOID TUMOR: A MULTICENTER STUDY
title_fullStr	EVALUATION OF CLINICAL AND LABORATORY CHARACTERISTICS OF CHILDREN WITH RHABDOID TUMOR: A MULTICENTER STUDY
title_full_unstemmed	EVALUATION OF CLINICAL AND LABORATORY CHARACTERISTICS OF CHILDREN WITH RHABDOID TUMOR: A MULTICENTER STUDY
title_sort	evaluation of clinical and laboratory characteristics of children with rhabdoid tumor: a multicenter study
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/0154714528984f74b8b6314ef38cda86
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EVALUATION OF CLINICAL AND LABORATORY CHARACTERISTICS OF CHILDREN WITH RHABDOID TUMOR: A MULTICENTER STUDY

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