Structure-guided development of heterodimer-selective GPCR ligands

G protein-coupled receptors (GPCRs) are involved in key signalling pathways and represent important targets for the treatment of neurological and psychiatric disorders. Here, the authors describe powerful bivalent ligands that efficiently bind to therapeutically relevant GPCR heterodimers

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Autores principales:	Harald Hübner, Tamara Schellhorn, Marie Gienger, Carolin Schaab, Jonas Kaindl, Laurin Leeb, Timothy Clark, Dorothee Möller, Peter Gmeiner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0157f3da6f7d40b3b16bfeb4284db320
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spelling	oai:doaj.org-article:0157f3da6f7d40b3b16bfeb4284db3202021-12-02T17:32:52ZStructure-guided development of heterodimer-selective GPCR ligands10.1038/ncomms122982041-1723https://doaj.org/article/0157f3da6f7d40b3b16bfeb4284db3202016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12298https://doaj.org/toc/2041-1723G protein-coupled receptors (GPCRs) are involved in key signalling pathways and represent important targets for the treatment of neurological and psychiatric disorders. Here, the authors describe powerful bivalent ligands that efficiently bind to therapeutically relevant GPCR heterodimersHarald HübnerTamara SchellhornMarie GiengerCarolin SchaabJonas KaindlLaurin LeebTimothy ClarkDorothee MöllerPeter GmeinerNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Harald Hübner Tamara Schellhorn Marie Gienger Carolin Schaab Jonas Kaindl Laurin Leeb Timothy Clark Dorothee Möller Peter Gmeiner Structure-guided development of heterodimer-selective GPCR ligands
description	G protein-coupled receptors (GPCRs) are involved in key signalling pathways and represent important targets for the treatment of neurological and psychiatric disorders. Here, the authors describe powerful bivalent ligands that efficiently bind to therapeutically relevant GPCR heterodimers
format	article
author	Harald Hübner Tamara Schellhorn Marie Gienger Carolin Schaab Jonas Kaindl Laurin Leeb Timothy Clark Dorothee Möller Peter Gmeiner
author_facet	Harald Hübner Tamara Schellhorn Marie Gienger Carolin Schaab Jonas Kaindl Laurin Leeb Timothy Clark Dorothee Möller Peter Gmeiner
author_sort	Harald Hübner
title	Structure-guided development of heterodimer-selective GPCR ligands
title_short	Structure-guided development of heterodimer-selective GPCR ligands
title_full	Structure-guided development of heterodimer-selective GPCR ligands
title_fullStr	Structure-guided development of heterodimer-selective GPCR ligands
title_full_unstemmed	Structure-guided development of heterodimer-selective GPCR ligands
title_sort	structure-guided development of heterodimer-selective gpcr ligands
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/0157f3da6f7d40b3b16bfeb4284db320
work_keys_str_mv	AT haraldhubner structureguideddevelopmentofheterodimerselectivegpcrligands AT tamaraschellhorn structureguideddevelopmentofheterodimerselectivegpcrligands AT mariegienger structureguideddevelopmentofheterodimerselectivegpcrligands AT carolinschaab structureguideddevelopmentofheterodimerselectivegpcrligands AT jonaskaindl structureguideddevelopmentofheterodimerselectivegpcrligands AT laurinleeb structureguideddevelopmentofheterodimerselectivegpcrligands AT timothyclark structureguideddevelopmentofheterodimerselectivegpcrligands AT dorotheemoller structureguideddevelopmentofheterodimerselectivegpcrligands AT petergmeiner structureguideddevelopmentofheterodimerselectivegpcrligands
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Structure-guided development of heterodimer-selective GPCR ligands

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