Mucormycosis in Hematologic Malignancies: Clinical Follow-Up and Treatment Results

Introduction:Mucormycosis is an aggressive-progressive invasive fungal infection caused by mold fungi in the division of mucorales of the zygomycetes class with high mortality, and is the most common fungal infection in patients with hematologic malignancies.Methods:This study retrospectively evalua...

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Autores principales:	Nagehan Didem Sarı, Istemi Serin, Tolga Kırgezen, Mehmet Hilmi Doğu
Formato:	article
Lenguaje:	EN
Publicado:	Galenos Yayinevi 2021
Materias:	fungal infection mucormycosis hematology Medicine R
Acceso en línea:	https://doaj.org/article/0158689f9e3f41e4b56c2b3eabf5c4b3
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spelling	oai:doaj.org-article:0158689f9e3f41e4b56c2b3eabf5c4b32021-11-23T10:25:25ZMucormycosis in Hematologic Malignancies: Clinical Follow-Up and Treatment Results2619-97932148-094X10.4274/imj.galenos.2021.65872https://doaj.org/article/0158689f9e3f41e4b56c2b3eabf5c4b32021-11-01T00:00:00Z http://istanbulmedicaljournal.org/archives/archive-detail/article-preview/mucormycosis-in-hematologic-malignancies-clinical-/49705 https://doaj.org/toc/2619-9793https://doaj.org/toc/2148-094XIntroduction:Mucormycosis is an aggressive-progressive invasive fungal infection caused by mold fungi in the division of mucorales of the zygomycetes class with high mortality, and is the most common fungal infection in patients with hematologic malignancies.Methods:This study retrospectively evaluated patients with mucormycosis diagnosis between January 2015 and December 2019, including demographic features, hematologic diseases and comorbidities, radiological evaluations, symptoms and signs, treatments, and outcomes.Results:Maxillofacial 9/19 (47.37%) of patients and 10/19 (59.9%) rhinoorbital mucor. Hematologic malignancy was observed in 15 (78.95%) patients, whereas others had additional pre-disposing factors, such as diabetes mellitus and chronic renal failure. The most common find-ings were persistent fever, mucopurulent nasal flux, and periorbital edema. Endoscopic sinus surgery + medication was administered in 12/19 (62.2%) patients and antifungal therapy in 7/19 (37.8%). In addition, 15/19 (79.95%) patients died and 4/19 recovered with sequela.Conclusion:The first large-scale mucormycosis study from our country will guide in determining the treatment algorithm. Effective and early surgery and antifungal application reduce mortality in mucormycosis by early diagnosis and multidisciplinary approach, without bone destruction in the paranasal sinus computed tomography with recurrent fever and earlystage sinusitis finding by performing a biopsy.Nagehan Didem SarıIstemi SerinTolga KırgezenMehmet Hilmi DoğuGalenos Yayineviarticlefungal infectionmucormycosishematologyMedicineRENİstanbul Medical Journal, Vol 22, Iss 4, Pp 245-249 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	fungal infection mucormycosis hematology Medicine R
spellingShingle	fungal infection mucormycosis hematology Medicine R Nagehan Didem Sarı Istemi Serin Tolga Kırgezen Mehmet Hilmi Doğu Mucormycosis in Hematologic Malignancies: Clinical Follow-Up and Treatment Results
description	Introduction:Mucormycosis is an aggressive-progressive invasive fungal infection caused by mold fungi in the division of mucorales of the zygomycetes class with high mortality, and is the most common fungal infection in patients with hematologic malignancies.Methods:This study retrospectively evaluated patients with mucormycosis diagnosis between January 2015 and December 2019, including demographic features, hematologic diseases and comorbidities, radiological evaluations, symptoms and signs, treatments, and outcomes.Results:Maxillofacial 9/19 (47.37%) of patients and 10/19 (59.9%) rhinoorbital mucor. Hematologic malignancy was observed in 15 (78.95%) patients, whereas others had additional pre-disposing factors, such as diabetes mellitus and chronic renal failure. The most common find-ings were persistent fever, mucopurulent nasal flux, and periorbital edema. Endoscopic sinus surgery + medication was administered in 12/19 (62.2%) patients and antifungal therapy in 7/19 (37.8%). In addition, 15/19 (79.95%) patients died and 4/19 recovered with sequela.Conclusion:The first large-scale mucormycosis study from our country will guide in determining the treatment algorithm. Effective and early surgery and antifungal application reduce mortality in mucormycosis by early diagnosis and multidisciplinary approach, without bone destruction in the paranasal sinus computed tomography with recurrent fever and earlystage sinusitis finding by performing a biopsy.
format	article
author	Nagehan Didem Sarı Istemi Serin Tolga Kırgezen Mehmet Hilmi Doğu
author_facet	Nagehan Didem Sarı Istemi Serin Tolga Kırgezen Mehmet Hilmi Doğu
author_sort	Nagehan Didem Sarı
title	Mucormycosis in Hematologic Malignancies: Clinical Follow-Up and Treatment Results
title_short	Mucormycosis in Hematologic Malignancies: Clinical Follow-Up and Treatment Results
title_full	Mucormycosis in Hematologic Malignancies: Clinical Follow-Up and Treatment Results
title_fullStr	Mucormycosis in Hematologic Malignancies: Clinical Follow-Up and Treatment Results
title_full_unstemmed	Mucormycosis in Hematologic Malignancies: Clinical Follow-Up and Treatment Results
title_sort	mucormycosis in hematologic malignancies: clinical follow-up and treatment results
publisher	Galenos Yayinevi
publishDate	2021
url	https://doaj.org/article/0158689f9e3f41e4b56c2b3eabf5c4b3
work_keys_str_mv	AT nagehandidemsarı mucormycosisinhematologicmalignanciesclinicalfollowupandtreatmentresults AT istemiserin mucormycosisinhematologicmalignanciesclinicalfollowupandtreatmentresults AT tolgakırgezen mucormycosisinhematologicmalignanciesclinicalfollowupandtreatmentresults AT mehmethilmidogu mucormycosisinhematologicmalignanciesclinicalfollowupandtreatmentresults
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Mucormycosis in Hematologic Malignancies: Clinical Follow-Up and Treatment Results

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