Cognitive manic symptoms in bipolar disorder associated with polymorphisms in the DAOA and COMT genes.

<h4>Introduction</h4>Bipolar disorder is characterized by severe mood symptoms including major depressive and manic episodes. During manic episodes, many patients show cognitive dysfunction. Dopamine and glutamate are important for cognitive processing, thus the COMT and DAOA genes that...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Dzana Sudic Hukic, Louise Frisén, Lena Backlund, Catharina Lavebratt, Mikael Landén, Lil Träskman-Bendz, Gunnar Edman, Martin Schalling, Urban Ösby
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/01590f5e0818441f9cf24260a6d5d985
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:01590f5e0818441f9cf24260a6d5d985
record_format	dspace
spelling	oai:doaj.org-article:01590f5e0818441f9cf24260a6d5d9852021-11-18T07:38:27ZCognitive manic symptoms in bipolar disorder associated with polymorphisms in the DAOA and COMT genes.1932-620310.1371/journal.pone.0067450https://doaj.org/article/01590f5e0818441f9cf24260a6d5d9852013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23861766/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Introduction</h4>Bipolar disorder is characterized by severe mood symptoms including major depressive and manic episodes. During manic episodes, many patients show cognitive dysfunction. Dopamine and glutamate are important for cognitive processing, thus the COMT and DAOA genes that modulate the expression of these neurotransmitters are of interest for studies of cognitive function.<h4>Methodology</h4>Focusing on the most severe episode of mania, a factor was found with the combined symptoms of talkativeness, distractibility, and thought disorder, considered a cognitive manic symptoms (CMS) factor. 488 patients were genotyped, out of which 373 (76%) had talkativeness, 269 (55%) distractibility, and 372 (76%) thought disorder. 215 (44%) patients were positive for all three symptoms, thus showing CMS (Table 1). As population controls, 1,044 anonymous blood donors (ABD) were used. Case-case and case-control design models were used to investigate genetic associations between cognitive manic symptoms in bipolar 1 disorder and SNPs in the COMT and DAOA genes. [Table: see text].<h4>Results</h4>The finding of this study was that cognitive manic symptoms in patients with bipolar 1 disorder was associated with genetic variants in the DAOA and COMT genes. Nominal association for DAOA SNPs and COMT SNPs to cognitive symptoms factor in bipolar 1 disorder was found in both allelic (Table 2) and haplotypic (Table 3) analyses. Genotypic association analyses also supported our findings. However, only one association, when CMS patients were compared to ABD controls, survived correction for multiple testing by max (T) permutation. Data also suggested interaction between SNPs rs2391191 in DAOA and rs5993883 in COMT in the case-control model. [Table: see text] [Table: see text].<h4>Conclusion</h4>Identifying genes associated with cognitive functioning has clinical implications for assessment of prognosis and progression. Our finding are consistent with other studies showing genetic associations between the COMT and DAOA genes and impaired cognition both in psychiatric disorders and in the general population.Dzana Sudic HukicLouise FrisénLena BacklundCatharina LavebrattMikael LandénLil Träskman-BendzGunnar EdmanMartin SchallingUrban ÖsbyPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 7, p e67450 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dzana Sudic Hukic Louise Frisén Lena Backlund Catharina Lavebratt Mikael Landén Lil Träskman-Bendz Gunnar Edman Martin Schalling Urban Ösby Cognitive manic symptoms in bipolar disorder associated with polymorphisms in the DAOA and COMT genes.
description	<h4>Introduction</h4>Bipolar disorder is characterized by severe mood symptoms including major depressive and manic episodes. During manic episodes, many patients show cognitive dysfunction. Dopamine and glutamate are important for cognitive processing, thus the COMT and DAOA genes that modulate the expression of these neurotransmitters are of interest for studies of cognitive function.<h4>Methodology</h4>Focusing on the most severe episode of mania, a factor was found with the combined symptoms of talkativeness, distractibility, and thought disorder, considered a cognitive manic symptoms (CMS) factor. 488 patients were genotyped, out of which 373 (76%) had talkativeness, 269 (55%) distractibility, and 372 (76%) thought disorder. 215 (44%) patients were positive for all three symptoms, thus showing CMS (Table 1). As population controls, 1,044 anonymous blood donors (ABD) were used. Case-case and case-control design models were used to investigate genetic associations between cognitive manic symptoms in bipolar 1 disorder and SNPs in the COMT and DAOA genes. [Table: see text].<h4>Results</h4>The finding of this study was that cognitive manic symptoms in patients with bipolar 1 disorder was associated with genetic variants in the DAOA and COMT genes. Nominal association for DAOA SNPs and COMT SNPs to cognitive symptoms factor in bipolar 1 disorder was found in both allelic (Table 2) and haplotypic (Table 3) analyses. Genotypic association analyses also supported our findings. However, only one association, when CMS patients were compared to ABD controls, survived correction for multiple testing by max (T) permutation. Data also suggested interaction between SNPs rs2391191 in DAOA and rs5993883 in COMT in the case-control model. [Table: see text] [Table: see text].<h4>Conclusion</h4>Identifying genes associated with cognitive functioning has clinical implications for assessment of prognosis and progression. Our finding are consistent with other studies showing genetic associations between the COMT and DAOA genes and impaired cognition both in psychiatric disorders and in the general population.
format	article
author	Dzana Sudic Hukic Louise Frisén Lena Backlund Catharina Lavebratt Mikael Landén Lil Träskman-Bendz Gunnar Edman Martin Schalling Urban Ösby
author_facet	Dzana Sudic Hukic Louise Frisén Lena Backlund Catharina Lavebratt Mikael Landén Lil Träskman-Bendz Gunnar Edman Martin Schalling Urban Ösby
author_sort	Dzana Sudic Hukic
title	Cognitive manic symptoms in bipolar disorder associated with polymorphisms in the DAOA and COMT genes.
title_short	Cognitive manic symptoms in bipolar disorder associated with polymorphisms in the DAOA and COMT genes.
title_full	Cognitive manic symptoms in bipolar disorder associated with polymorphisms in the DAOA and COMT genes.
title_fullStr	Cognitive manic symptoms in bipolar disorder associated with polymorphisms in the DAOA and COMT genes.
title_full_unstemmed	Cognitive manic symptoms in bipolar disorder associated with polymorphisms in the DAOA and COMT genes.
title_sort	cognitive manic symptoms in bipolar disorder associated with polymorphisms in the daoa and comt genes.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/01590f5e0818441f9cf24260a6d5d985
work_keys_str_mv	AT dzanasudichukic cognitivemanicsymptomsinbipolardisorderassociatedwithpolymorphismsinthedaoaandcomtgenes AT louisefrisen cognitivemanicsymptomsinbipolardisorderassociatedwithpolymorphismsinthedaoaandcomtgenes AT lenabacklund cognitivemanicsymptomsinbipolardisorderassociatedwithpolymorphismsinthedaoaandcomtgenes AT catharinalavebratt cognitivemanicsymptomsinbipolardisorderassociatedwithpolymorphismsinthedaoaandcomtgenes AT mikaellanden cognitivemanicsymptomsinbipolardisorderassociatedwithpolymorphismsinthedaoaandcomtgenes AT liltraskmanbendz cognitivemanicsymptomsinbipolardisorderassociatedwithpolymorphismsinthedaoaandcomtgenes AT gunnaredman cognitivemanicsymptomsinbipolardisorderassociatedwithpolymorphismsinthedaoaandcomtgenes AT martinschalling cognitivemanicsymptomsinbipolardisorderassociatedwithpolymorphismsinthedaoaandcomtgenes AT urbanosby cognitivemanicsymptomsinbipolardisorderassociatedwithpolymorphismsinthedaoaandcomtgenes
_version_	1718423139059236864

Cognitive manic symptoms in bipolar disorder associated with polymorphisms in the DAOA and COMT genes.

Ejemplares similares