Identification of a novel inhibitor of liver cancer cell invasion and proliferation through regulation of Akt and Twist1

Abstract When primary cancer faces limited oxygen and nutrient supply, it undergoes an epithelial–mesenchymal transition, which increases cancer cell motility and invasiveness. The migratory and invasive cancer cells often exert aggressive cancer development or even cancer metastasis. In this study,...

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Autores principales:	Jain Ha, Sewoong Lee, Jiyoung Park, Jihye Seo, Eunjeong Kang, Haelim Yoon, Ba Reum Kim, Hyeon Kyu Lee, Seong Eon Ryu, Sayeon Cho
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0159a810a6fa4038bcbcf137a069a74a
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spelling	oai:doaj.org-article:0159a810a6fa4038bcbcf137a069a74a2021-12-02T18:51:41ZIdentification of a novel inhibitor of liver cancer cell invasion and proliferation through regulation of Akt and Twist110.1038/s41598-021-95933-42045-2322https://doaj.org/article/0159a810a6fa4038bcbcf137a069a74a2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95933-4https://doaj.org/toc/2045-2322Abstract When primary cancer faces limited oxygen and nutrient supply, it undergoes an epithelial–mesenchymal transition, which increases cancer cell motility and invasiveness. The migratory and invasive cancer cells often exert aggressive cancer development or even cancer metastasis. In this study, we investigated a novel compound, 3-acetyl-5,8-dichloro-2-((2,4-dichlorophenyl)amino)quinolin-4(1H)-one (ADQ), that showed significant suppression of wound healing and cellular invasion. This compound also inhibited anchorage-independent cell growth, multicellular tumor spheroid survival/invasion, and metalloprotease activities. The anti-proliferative effects of ADQ were mediated by inhibition of the Akt pathway. In addition, ADQ reduced the expression of mesenchymal markers of cancer cells, which was associated with the suppressed expression of Twist1. In conclusion, ADQ successfully suppressed carcinogenic activity by inhibiting the Akt signaling pathway and Twist1, which suggests that ADQ may be an efficient candidate for cancer drug development.Jain HaSewoong LeeJiyoung ParkJihye SeoEunjeong KangHaelim YoonBa Reum KimHyeon Kyu LeeSeong Eon RyuSayeon ChoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jain Ha Sewoong Lee Jiyoung Park Jihye Seo Eunjeong Kang Haelim Yoon Ba Reum Kim Hyeon Kyu Lee Seong Eon Ryu Sayeon Cho Identification of a novel inhibitor of liver cancer cell invasion and proliferation through regulation of Akt and Twist1
description	Abstract When primary cancer faces limited oxygen and nutrient supply, it undergoes an epithelial–mesenchymal transition, which increases cancer cell motility and invasiveness. The migratory and invasive cancer cells often exert aggressive cancer development or even cancer metastasis. In this study, we investigated a novel compound, 3-acetyl-5,8-dichloro-2-((2,4-dichlorophenyl)amino)quinolin-4(1H)-one (ADQ), that showed significant suppression of wound healing and cellular invasion. This compound also inhibited anchorage-independent cell growth, multicellular tumor spheroid survival/invasion, and metalloprotease activities. The anti-proliferative effects of ADQ were mediated by inhibition of the Akt pathway. In addition, ADQ reduced the expression of mesenchymal markers of cancer cells, which was associated with the suppressed expression of Twist1. In conclusion, ADQ successfully suppressed carcinogenic activity by inhibiting the Akt signaling pathway and Twist1, which suggests that ADQ may be an efficient candidate for cancer drug development.
format	article
author	Jain Ha Sewoong Lee Jiyoung Park Jihye Seo Eunjeong Kang Haelim Yoon Ba Reum Kim Hyeon Kyu Lee Seong Eon Ryu Sayeon Cho
author_facet	Jain Ha Sewoong Lee Jiyoung Park Jihye Seo Eunjeong Kang Haelim Yoon Ba Reum Kim Hyeon Kyu Lee Seong Eon Ryu Sayeon Cho
author_sort	Jain Ha
title	Identification of a novel inhibitor of liver cancer cell invasion and proliferation through regulation of Akt and Twist1
title_short	Identification of a novel inhibitor of liver cancer cell invasion and proliferation through regulation of Akt and Twist1
title_full	Identification of a novel inhibitor of liver cancer cell invasion and proliferation through regulation of Akt and Twist1
title_fullStr	Identification of a novel inhibitor of liver cancer cell invasion and proliferation through regulation of Akt and Twist1
title_full_unstemmed	Identification of a novel inhibitor of liver cancer cell invasion and proliferation through regulation of Akt and Twist1
title_sort	identification of a novel inhibitor of liver cancer cell invasion and proliferation through regulation of akt and twist1
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0159a810a6fa4038bcbcf137a069a74a
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Identification of a novel inhibitor of liver cancer cell invasion and proliferation through regulation of Akt and Twist1

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