Nutrition and cognition across the lifetime: an overview on epigenetic mechanisms

The functioning of our brain depends on both genes and their interactions with environmental factors. The close link between genetics and environmental factors produces structural and functional cerebral changes early on in life. Understanding the weight of environmental factors in modulating neurop...

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Autores principales:	Arianna Polverino, Pierpaolo Sorrentino, Matteo Pesoli, Laura Mandolesi
Formato:	article
Lenguaje:	EN
Publicado:	AIMS Press 2021
Materias:	nutrition cognitive functioning environmental factors epigenetics neuroplasticity Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/015aadfac86d409ba885665e72552c2e
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spelling	oai:doaj.org-article:015aadfac86d409ba885665e72552c2e2021-12-02T01:15:11ZNutrition and cognition across the lifetime: an overview on epigenetic mechanisms10.3934/Neuroscience.20210242373-7972https://doaj.org/article/015aadfac86d409ba885665e72552c2e2021-07-01T00:00:00Zhttp://www.aimspress.com/article/doi/10.3934/Neuroscience.2021024?viewType=HTMLhttps://doaj.org/toc/2373-7972The functioning of our brain depends on both genes and their interactions with environmental factors. The close link between genetics and environmental factors produces structural and functional cerebral changes early on in life. Understanding the weight of environmental factors in modulating neuroplasticity phenomena and cognitive functioning is relevant for potential interventions. Among these, nutrition plays a key role. In fact, the link between gut and brain (the gut-brain axis) is very close and begins in utero, since the Central Nervous System (CNS) and the Enteric Nervous System (ENS) originate from the same germ layer during the embryogenesis. Here, we investigate the epigenetic mechanisms induced by some nutrients on the cognitive functioning, which affect the cellular and molecular processes governing our cognitive functions. Furthermore, epigenetic phenomena can be positively affected by specific healthy nutrients from diet, with the possibility of preventing or modulating cognitive impairments. Specifically, we described the effects of several nutrients on diet-dependent epigenetic processes, in particular DNA methylation and histones post-translational modifications, and their potential role as therapeutic target, to describe how some forms of cognitive decline could be prevented or modulated from the early stages of life.Arianna PolverinoPierpaolo SorrentinoMatteo Pesoli Laura Mandolesi AIMS Pressarticlenutritioncognitive functioningenvironmental factorsepigeneticsneuroplasticityNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENAIMS Neuroscience, Vol 8, Iss 4, Pp 448-476 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	nutrition cognitive functioning environmental factors epigenetics neuroplasticity Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	nutrition cognitive functioning environmental factors epigenetics neuroplasticity Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Arianna Polverino Pierpaolo Sorrentino Matteo Pesoli Laura Mandolesi Nutrition and cognition across the lifetime: an overview on epigenetic mechanisms
description	The functioning of our brain depends on both genes and their interactions with environmental factors. The close link between genetics and environmental factors produces structural and functional cerebral changes early on in life. Understanding the weight of environmental factors in modulating neuroplasticity phenomena and cognitive functioning is relevant for potential interventions. Among these, nutrition plays a key role. In fact, the link between gut and brain (the gut-brain axis) is very close and begins in utero, since the Central Nervous System (CNS) and the Enteric Nervous System (ENS) originate from the same germ layer during the embryogenesis. Here, we investigate the epigenetic mechanisms induced by some nutrients on the cognitive functioning, which affect the cellular and molecular processes governing our cognitive functions. Furthermore, epigenetic phenomena can be positively affected by specific healthy nutrients from diet, with the possibility of preventing or modulating cognitive impairments. Specifically, we described the effects of several nutrients on diet-dependent epigenetic processes, in particular DNA methylation and histones post-translational modifications, and their potential role as therapeutic target, to describe how some forms of cognitive decline could be prevented or modulated from the early stages of life.
format	article
author	Arianna Polverino Pierpaolo Sorrentino Matteo Pesoli Laura Mandolesi
author_facet	Arianna Polverino Pierpaolo Sorrentino Matteo Pesoli Laura Mandolesi
author_sort	Arianna Polverino
title	Nutrition and cognition across the lifetime: an overview on epigenetic mechanisms
title_short	Nutrition and cognition across the lifetime: an overview on epigenetic mechanisms
title_full	Nutrition and cognition across the lifetime: an overview on epigenetic mechanisms
title_fullStr	Nutrition and cognition across the lifetime: an overview on epigenetic mechanisms
title_full_unstemmed	Nutrition and cognition across the lifetime: an overview on epigenetic mechanisms
title_sort	nutrition and cognition across the lifetime: an overview on epigenetic mechanisms
publisher	AIMS Press
publishDate	2021
url	https://doaj.org/article/015aadfac86d409ba885665e72552c2e
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Nutrition and cognition across the lifetime: an overview on epigenetic mechanisms

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