Study on the role of autophagy in the occurrence and development of liver diseases

Autophagy is a process of lysosome degradation, which plays an important role in maintaining cell homeostasis and organ integrity through the degradation of misfolded proteins, removal of damaged organelles and excess lipids, which is one of the research hotspots in recent years. Liver disease of...

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Autores principales:	Xiao-Bin Qin, De-Wen Mao
Formato:	article
Lenguaje:	EN
Publicado:	Editorial Board of Journal of Hainan Medical University 2021
Materias:	autophagy viral hepatitis non-alcoholic fatty liver disease hepatic fibrosis acute hepatic failure primary hepatic carcinoma Medicine R
Acceso en línea:	https://doaj.org/article/015db20824bf4137bbeca3c66cfe2467
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spelling	oai:doaj.org-article:015db20824bf4137bbeca3c66cfe24672021-12-01T05:24:51ZStudy on the role of autophagy in the occurrence and development of liver diseases1007-1237https://doaj.org/article/015db20824bf4137bbeca3c66cfe24672021-10-01T00:00:00Zhttp://www.hnykdxxb.com/PDF/202120/13.pdfhttps://doaj.org/toc/1007-1237Autophagy is a process of lysosome degradation, which plays an important role in maintaining cell homeostasis and organ integrity through the degradation of misfolded proteins, removal of damaged organelles and excess lipids, which is one of the research hotspots in recent years. Liver disease often develops into chronic disease with high mortality, which seriously affects the life safety and quality of life of patients. Studies have shown that autophagy participates in the processes of cellular immunity and oxidative stress, plays an important role in a variety of liver diseases, has the characteristics of two-way regulation, and moderate autophagy has a protective effect. Excessive or dysfunctional autophagy can promote cell death and lead to the occurrence and development of the disease. at present, regulating autophagy is considered as a potential treatment. Based on chronic viral hepatitis, liver fibrosis, non-alcoholic fatty liver disease, acute liver failure and primary liver cancer, this paper reviews the functional characteristics and regulatory mechanism of autophagy in liver diseases. to explore new therapeutic targets for liver diseases, in order to provide new ideas and basis for clinical diagnosis and treatment.Xiao-Bin QinDe-Wen MaoEditorial Board of Journal of Hainan Medical Universityarticleautophagyviral hepatitisnon-alcoholic fatty liver diseasehepatic fibrosisacute hepatic failureprimary hepatic carcinomaMedicineRENJournal of Hainan Medical University, Vol 27, Iss 20, Pp 64-68 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	autophagy viral hepatitis non-alcoholic fatty liver disease hepatic fibrosis acute hepatic failure primary hepatic carcinoma Medicine R
spellingShingle	autophagy viral hepatitis non-alcoholic fatty liver disease hepatic fibrosis acute hepatic failure primary hepatic carcinoma Medicine R Xiao-Bin Qin De-Wen Mao Study on the role of autophagy in the occurrence and development of liver diseases
description	Autophagy is a process of lysosome degradation, which plays an important role in maintaining cell homeostasis and organ integrity through the degradation of misfolded proteins, removal of damaged organelles and excess lipids, which is one of the research hotspots in recent years. Liver disease often develops into chronic disease with high mortality, which seriously affects the life safety and quality of life of patients. Studies have shown that autophagy participates in the processes of cellular immunity and oxidative stress, plays an important role in a variety of liver diseases, has the characteristics of two-way regulation, and moderate autophagy has a protective effect. Excessive or dysfunctional autophagy can promote cell death and lead to the occurrence and development of the disease. at present, regulating autophagy is considered as a potential treatment. Based on chronic viral hepatitis, liver fibrosis, non-alcoholic fatty liver disease, acute liver failure and primary liver cancer, this paper reviews the functional characteristics and regulatory mechanism of autophagy in liver diseases. to explore new therapeutic targets for liver diseases, in order to provide new ideas and basis for clinical diagnosis and treatment.
format	article
author	Xiao-Bin Qin De-Wen Mao
author_facet	Xiao-Bin Qin De-Wen Mao
author_sort	Xiao-Bin Qin
title	Study on the role of autophagy in the occurrence and development of liver diseases
title_short	Study on the role of autophagy in the occurrence and development of liver diseases
title_full	Study on the role of autophagy in the occurrence and development of liver diseases
title_fullStr	Study on the role of autophagy in the occurrence and development of liver diseases
title_full_unstemmed	Study on the role of autophagy in the occurrence and development of liver diseases
title_sort	study on the role of autophagy in the occurrence and development of liver diseases
publisher	Editorial Board of Journal of Hainan Medical University
publishDate	2021
url	https://doaj.org/article/015db20824bf4137bbeca3c66cfe2467
work_keys_str_mv	AT xiaobinqin studyontheroleofautophagyintheoccurrenceanddevelopmentofliverdiseases AT dewenmao studyontheroleofautophagyintheoccurrenceanddevelopmentofliverdiseases
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Study on the role of autophagy in the occurrence and development of liver diseases

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