Schizophrenia-related microdeletion causes defective ciliary motility and brain ventricle enlargement via microRNA-dependent mechanisms in mice

Schizophrenia-related microdeletion causes defective ciliary motility and brain ventricle enlargement via microRNA-dependent mechanisms in mice

Schizophrenia is associated with brain ventricular enlargement. Here, the authors show in mice that 22q11 deletion, which is associated with schizophrenia, causes ventricular enlargement and motility abnormalities in cilia lining ventricle walls via a microRNA mechanism.

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Autores principales: Tae-Yeon Eom, Seung Baek Han, Jieun Kim, Jay A. Blundon, Yong-Dong Wang, Jing Yu, Kara Anderson, Damian B. Kaminski, Sadie Miki Sakurada, Shondra M. Pruett-Miller, Linda Horner, Ben Wagner, Camenzind G. Robinson, Matthew Eicholtz, Derek C. Rose, Stanislav S. Zakharenko
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/015f5351a7344fa99035595c0123d9f5
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spelling oai:doaj.org-article:015f5351a7344fa99035595c0123d9f52021-12-02T17:32:58ZSchizophrenia-related microdeletion causes defective ciliary motility and brain ventricle enlargement via microRNA-dependent mechanisms in mice10.1038/s41467-020-14628-y2041-1723https://doaj.org/article/015f5351a7344fa99035595c0123d9f52020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14628-yhttps://doaj.org/toc/2041-1723Schizophrenia is associated with brain ventricular enlargement. Here, the authors show in mice that 22q11 deletion, which is associated with schizophrenia, causes ventricular enlargement and motility abnormalities in cilia lining ventricle walls via a microRNA mechanism.Tae-Yeon EomSeung Baek HanJieun KimJay A. BlundonYong-Dong WangJing YuKara AndersonDamian B. KaminskiSadie Miki SakuradaShondra M. Pruett-MillerLinda HornerBen WagnerCamenzind G. RobinsonMatthew EicholtzDerek C. RoseStanislav S. ZakharenkoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Tae-Yeon Eom
Seung Baek Han
Jieun Kim
Jay A. Blundon
Yong-Dong Wang
Jing Yu
Kara Anderson
Damian B. Kaminski
Sadie Miki Sakurada
Shondra M. Pruett-Miller
Linda Horner
Ben Wagner
Camenzind G. Robinson
Matthew Eicholtz
Derek C. Rose
Stanislav S. Zakharenko
Schizophrenia-related microdeletion causes defective ciliary motility and brain ventricle enlargement via microRNA-dependent mechanisms in mice
description Schizophrenia is associated with brain ventricular enlargement. Here, the authors show in mice that 22q11 deletion, which is associated with schizophrenia, causes ventricular enlargement and motility abnormalities in cilia lining ventricle walls via a microRNA mechanism.
format article
author Tae-Yeon Eom
Seung Baek Han
Jieun Kim
Jay A. Blundon
Yong-Dong Wang
Jing Yu
Kara Anderson
Damian B. Kaminski
Sadie Miki Sakurada
Shondra M. Pruett-Miller
Linda Horner
Ben Wagner
Camenzind G. Robinson
Matthew Eicholtz
Derek C. Rose
Stanislav S. Zakharenko
author_facet Tae-Yeon Eom
Seung Baek Han
Jieun Kim
Jay A. Blundon
Yong-Dong Wang
Jing Yu
Kara Anderson
Damian B. Kaminski
Sadie Miki Sakurada
Shondra M. Pruett-Miller
Linda Horner
Ben Wagner
Camenzind G. Robinson
Matthew Eicholtz
Derek C. Rose
Stanislav S. Zakharenko
author_sort Tae-Yeon Eom
title Schizophrenia-related microdeletion causes defective ciliary motility and brain ventricle enlargement via microRNA-dependent mechanisms in mice
title_short Schizophrenia-related microdeletion causes defective ciliary motility and brain ventricle enlargement via microRNA-dependent mechanisms in mice
title_full Schizophrenia-related microdeletion causes defective ciliary motility and brain ventricle enlargement via microRNA-dependent mechanisms in mice
title_fullStr Schizophrenia-related microdeletion causes defective ciliary motility and brain ventricle enlargement via microRNA-dependent mechanisms in mice
title_full_unstemmed Schizophrenia-related microdeletion causes defective ciliary motility and brain ventricle enlargement via microRNA-dependent mechanisms in mice
title_sort schizophrenia-related microdeletion causes defective ciliary motility and brain ventricle enlargement via microrna-dependent mechanisms in mice
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/015f5351a7344fa99035595c0123d9f5
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