EGFR feedback-inhibition by Ran-binding protein 6 is disrupted in cancer

The epidermal growth factor receptor (EGFR) signalling is regulated at multiple levels. Here the authors show that the importin RanBP6 acts as a tumor suppressor in Glioblastoma and regulates EGFR signalling through promoting translocation of STAT3 to the nuclei and repressing EGFR transcription.

Guardado en:

Detalles Bibliográficos
Autores principales:	Barbara Oldrini, Wan-Ying Hsieh, Hediye Erdjument-Bromage, Paolo Codega, Maria Stella Carro, Alvaro Curiel-García, Carl Campos, Maryam Pourmaleki, Christian Grommes, Igor Vivanco, Daniel Rohle, Craig M. Bielski, Barry S. Taylor, Travis J. Hollmann, Marc Rosenblum, Paul Tempst, John Blenis, Massimo Squatrito, Ingo K. Mellinghoff
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/015fa09cb6784ac18a7db7bbdca85e1c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:015fa09cb6784ac18a7db7bbdca85e1c
record_format	dspace
spelling	oai:doaj.org-article:015fa09cb6784ac18a7db7bbdca85e1c2021-12-02T17:01:18ZEGFR feedback-inhibition by Ran-binding protein 6 is disrupted in cancer10.1038/s41467-017-02185-w2041-1723https://doaj.org/article/015fa09cb6784ac18a7db7bbdca85e1c2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02185-whttps://doaj.org/toc/2041-1723The epidermal growth factor receptor (EGFR) signalling is regulated at multiple levels. Here the authors show that the importin RanBP6 acts as a tumor suppressor in Glioblastoma and regulates EGFR signalling through promoting translocation of STAT3 to the nuclei and repressing EGFR transcription.Barbara OldriniWan-Ying HsiehHediye Erdjument-BromagePaolo CodegaMaria Stella CarroAlvaro Curiel-GarcíaCarl CamposMaryam PourmalekiChristian GrommesIgor VivancoDaniel RohleCraig M. BielskiBarry S. TaylorTravis J. HollmannMarc RosenblumPaul TempstJohn BlenisMassimo SquatritoIngo K. MellinghoffNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Barbara Oldrini Wan-Ying Hsieh Hediye Erdjument-Bromage Paolo Codega Maria Stella Carro Alvaro Curiel-García Carl Campos Maryam Pourmaleki Christian Grommes Igor Vivanco Daniel Rohle Craig M. Bielski Barry S. Taylor Travis J. Hollmann Marc Rosenblum Paul Tempst John Blenis Massimo Squatrito Ingo K. Mellinghoff EGFR feedback-inhibition by Ran-binding protein 6 is disrupted in cancer
description	The epidermal growth factor receptor (EGFR) signalling is regulated at multiple levels. Here the authors show that the importin RanBP6 acts as a tumor suppressor in Glioblastoma and regulates EGFR signalling through promoting translocation of STAT3 to the nuclei and repressing EGFR transcription.
format	article
author	Barbara Oldrini Wan-Ying Hsieh Hediye Erdjument-Bromage Paolo Codega Maria Stella Carro Alvaro Curiel-García Carl Campos Maryam Pourmaleki Christian Grommes Igor Vivanco Daniel Rohle Craig M. Bielski Barry S. Taylor Travis J. Hollmann Marc Rosenblum Paul Tempst John Blenis Massimo Squatrito Ingo K. Mellinghoff
author_facet	Barbara Oldrini Wan-Ying Hsieh Hediye Erdjument-Bromage Paolo Codega Maria Stella Carro Alvaro Curiel-García Carl Campos Maryam Pourmaleki Christian Grommes Igor Vivanco Daniel Rohle Craig M. Bielski Barry S. Taylor Travis J. Hollmann Marc Rosenblum Paul Tempst John Blenis Massimo Squatrito Ingo K. Mellinghoff
author_sort	Barbara Oldrini
title	EGFR feedback-inhibition by Ran-binding protein 6 is disrupted in cancer
title_short	EGFR feedback-inhibition by Ran-binding protein 6 is disrupted in cancer
title_full	EGFR feedback-inhibition by Ran-binding protein 6 is disrupted in cancer
title_fullStr	EGFR feedback-inhibition by Ran-binding protein 6 is disrupted in cancer
title_full_unstemmed	EGFR feedback-inhibition by Ran-binding protein 6 is disrupted in cancer
title_sort	egfr feedback-inhibition by ran-binding protein 6 is disrupted in cancer
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/015fa09cb6784ac18a7db7bbdca85e1c
work_keys_str_mv	AT barbaraoldrini egfrfeedbackinhibitionbyranbindingprotein6isdisruptedincancer AT wanyinghsieh egfrfeedbackinhibitionbyranbindingprotein6isdisruptedincancer AT hediyeerdjumentbromage egfrfeedbackinhibitionbyranbindingprotein6isdisruptedincancer AT paolocodega egfrfeedbackinhibitionbyranbindingprotein6isdisruptedincancer AT mariastellacarro egfrfeedbackinhibitionbyranbindingprotein6isdisruptedincancer AT alvarocurielgarcia egfrfeedbackinhibitionbyranbindingprotein6isdisruptedincancer AT carlcampos egfrfeedbackinhibitionbyranbindingprotein6isdisruptedincancer AT maryampourmaleki egfrfeedbackinhibitionbyranbindingprotein6isdisruptedincancer AT christiangrommes egfrfeedbackinhibitionbyranbindingprotein6isdisruptedincancer AT igorvivanco egfrfeedbackinhibitionbyranbindingprotein6isdisruptedincancer AT danielrohle egfrfeedbackinhibitionbyranbindingprotein6isdisruptedincancer AT craigmbielski egfrfeedbackinhibitionbyranbindingprotein6isdisruptedincancer AT barrystaylor egfrfeedbackinhibitionbyranbindingprotein6isdisruptedincancer AT travisjhollmann egfrfeedbackinhibitionbyranbindingprotein6isdisruptedincancer AT marcrosenblum egfrfeedbackinhibitionbyranbindingprotein6isdisruptedincancer AT paultempst egfrfeedbackinhibitionbyranbindingprotein6isdisruptedincancer AT johnblenis egfrfeedbackinhibitionbyranbindingprotein6isdisruptedincancer AT massimosquatrito egfrfeedbackinhibitionbyranbindingprotein6isdisruptedincancer AT ingokmellinghoff egfrfeedbackinhibitionbyranbindingprotein6isdisruptedincancer
_version_	1718382126735294464

EGFR feedback-inhibition by Ran-binding protein 6 is disrupted in cancer

Ejemplares similares