ROCK regulates the intermittent mode of interstitial T cell migration in inflamed lungs

ROCK is associated with T cell movement in lymph nodes. Here the authors use an LPS lung damage model and two-photon imaging to show that CD8+ T cells in lung tissue engage in ROCK-dependent fast linear migration alternating with bursts of slower confined migration that together optimize contact wit...

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Autores principales:	Paulus Mrass, Sreenivasa Rao Oruganti, G. Matthew Fricke, Justyna Tafoya, Janie R. Byrum, Lihua Yang, Samantha L. Hamilton, Mark J. Miller, Melanie E. Moses, Judy L. Cannon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0164cac4b97b4f608d1a66e156f4b2bd
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spelling	oai:doaj.org-article:0164cac4b97b4f608d1a66e156f4b2bd2021-12-02T14:40:34ZROCK regulates the intermittent mode of interstitial T cell migration in inflamed lungs10.1038/s41467-017-01032-22041-1723https://doaj.org/article/0164cac4b97b4f608d1a66e156f4b2bd2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01032-2https://doaj.org/toc/2041-1723ROCK is associated with T cell movement in lymph nodes. Here the authors use an LPS lung damage model and two-photon imaging to show that CD8+ T cells in lung tissue engage in ROCK-dependent fast linear migration alternating with bursts of slower confined migration that together optimize contact with target cells.Paulus MrassSreenivasa Rao OrugantiG. Matthew FrickeJustyna TafoyaJanie R. ByrumLihua YangSamantha L. HamiltonMark J. MillerMelanie E. MosesJudy L. CannonNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Paulus Mrass Sreenivasa Rao Oruganti G. Matthew Fricke Justyna Tafoya Janie R. Byrum Lihua Yang Samantha L. Hamilton Mark J. Miller Melanie E. Moses Judy L. Cannon ROCK regulates the intermittent mode of interstitial T cell migration in inflamed lungs
description	ROCK is associated with T cell movement in lymph nodes. Here the authors use an LPS lung damage model and two-photon imaging to show that CD8+ T cells in lung tissue engage in ROCK-dependent fast linear migration alternating with bursts of slower confined migration that together optimize contact with target cells.
format	article
author	Paulus Mrass Sreenivasa Rao Oruganti G. Matthew Fricke Justyna Tafoya Janie R. Byrum Lihua Yang Samantha L. Hamilton Mark J. Miller Melanie E. Moses Judy L. Cannon
author_facet	Paulus Mrass Sreenivasa Rao Oruganti G. Matthew Fricke Justyna Tafoya Janie R. Byrum Lihua Yang Samantha L. Hamilton Mark J. Miller Melanie E. Moses Judy L. Cannon
author_sort	Paulus Mrass
title	ROCK regulates the intermittent mode of interstitial T cell migration in inflamed lungs
title_short	ROCK regulates the intermittent mode of interstitial T cell migration in inflamed lungs
title_full	ROCK regulates the intermittent mode of interstitial T cell migration in inflamed lungs
title_fullStr	ROCK regulates the intermittent mode of interstitial T cell migration in inflamed lungs
title_full_unstemmed	ROCK regulates the intermittent mode of interstitial T cell migration in inflamed lungs
title_sort	rock regulates the intermittent mode of interstitial t cell migration in inflamed lungs
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0164cac4b97b4f608d1a66e156f4b2bd
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ROCK regulates the intermittent mode of interstitial T cell migration in inflamed lungs

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