Intracellular sodium elevation reprograms cardiac metabolism

The failing heart is characterised by both alterations in mitochondrial metabolism and an elevation of cytosolic sodium. Here, the authors use 23Na NMR and metabolic profiling to show these are related, and that elevation in intracellular Na reprograms cardiac substrate utilisation via effects on mi...

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Autores principales:	Dunja Aksentijević, Anja Karlstaedt, Marina V. Basalay, Brett A. O’Brien, David Sanchez-Tatay, Seda Eminaga, Alpesh Thakker, Daniel A. Tennant, William Fuller, Thomas R. Eykyn, Heinrich Taegtmeyer, Michael J. Shattock
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/01651cc80f9b4aad9898d7152d51f740
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spelling	oai:doaj.org-article:01651cc80f9b4aad9898d7152d51f7402021-12-02T16:34:55ZIntracellular sodium elevation reprograms cardiac metabolism10.1038/s41467-020-18160-x2041-1723https://doaj.org/article/01651cc80f9b4aad9898d7152d51f7402020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18160-xhttps://doaj.org/toc/2041-1723The failing heart is characterised by both alterations in mitochondrial metabolism and an elevation of cytosolic sodium. Here, the authors use 23Na NMR and metabolic profiling to show these are related, and that elevation in intracellular Na reprograms cardiac substrate utilisation via effects on mitochondrial Na/Ca exchange.Dunja AksentijevićAnja KarlstaedtMarina V. BasalayBrett A. O’BrienDavid Sanchez-TataySeda EminagaAlpesh ThakkerDaniel A. TennantWilliam FullerThomas R. EykynHeinrich TaegtmeyerMichael J. ShattockNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dunja Aksentijević Anja Karlstaedt Marina V. Basalay Brett A. O’Brien David Sanchez-Tatay Seda Eminaga Alpesh Thakker Daniel A. Tennant William Fuller Thomas R. Eykyn Heinrich Taegtmeyer Michael J. Shattock Intracellular sodium elevation reprograms cardiac metabolism
description	The failing heart is characterised by both alterations in mitochondrial metabolism and an elevation of cytosolic sodium. Here, the authors use 23Na NMR and metabolic profiling to show these are related, and that elevation in intracellular Na reprograms cardiac substrate utilisation via effects on mitochondrial Na/Ca exchange.
format	article
author	Dunja Aksentijević Anja Karlstaedt Marina V. Basalay Brett A. O’Brien David Sanchez-Tatay Seda Eminaga Alpesh Thakker Daniel A. Tennant William Fuller Thomas R. Eykyn Heinrich Taegtmeyer Michael J. Shattock
author_facet	Dunja Aksentijević Anja Karlstaedt Marina V. Basalay Brett A. O’Brien David Sanchez-Tatay Seda Eminaga Alpesh Thakker Daniel A. Tennant William Fuller Thomas R. Eykyn Heinrich Taegtmeyer Michael J. Shattock
author_sort	Dunja Aksentijević
title	Intracellular sodium elevation reprograms cardiac metabolism
title_short	Intracellular sodium elevation reprograms cardiac metabolism
title_full	Intracellular sodium elevation reprograms cardiac metabolism
title_fullStr	Intracellular sodium elevation reprograms cardiac metabolism
title_full_unstemmed	Intracellular sodium elevation reprograms cardiac metabolism
title_sort	intracellular sodium elevation reprograms cardiac metabolism
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/01651cc80f9b4aad9898d7152d51f740
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Intracellular sodium elevation reprograms cardiac metabolism

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