A V-to-F substitution in SK2 channels causes Ca2+ hypersensitivity and improves locomotion in a C. elegans ALS model

A V-to-F substitution in SK2 channels causes Ca2+ hypersensitivity and improves locomotion in a C. elegans ALS model

Abstract Small-conductance Ca2+-activated K+ (SK) channels mediate medium afterhyperpolarization in the neurons and play a key role in the regulation of neuronal excitability. SK channels are potential drug targets for ataxia and Amyotrophic Lateral Sclerosis (ALS). SK channels are activated exclusi...

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Autores principales: Young-Woo Nam, Saba N. Baskoylu, Dimitris Gazgalis, Razan Orfali, Meng Cui, Anne C. Hart, Miao Zhang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/01669cd7d6464d5bb3daf5452d2e06a8
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