Nanomedicine Strategies to Enhance Tumor Drug Penetration in Pancreatic Cancer

Tao Lu, Jai Prakash Engineered Therapeutics Group, Department of Biomaterials Science and Technology, University of Twente, Enschede, The NetherlandsCorrespondence: Jai PrakashEngineered Therapeutics, Department of Biomaterials Science and Technology, University of Twente, Drienerlolaan 5, Enschede,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lu T, Prakash J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	pancreatic ductal adenocarcinoma cancer-associated fibroblasts tumor stroma tumor vasculature drug perfusion drug penetration Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/016ad452d5cc4d7e982d295a6d6df70b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:016ad452d5cc4d7e982d295a6d6df70b
record_format	dspace
spelling	oai:doaj.org-article:016ad452d5cc4d7e982d295a6d6df70b2021-12-02T17:22:39ZNanomedicine Strategies to Enhance Tumor Drug Penetration in Pancreatic Cancer1178-2013https://doaj.org/article/016ad452d5cc4d7e982d295a6d6df70b2021-09-01T00:00:00Zhttps://www.dovepress.com/nanomedicine-strategies-to-enhance-tumor-drug-penetration-in-pancreati-peer-reviewed-fulltext-article-IJNhttps://doaj.org/toc/1178-2013Tao Lu, Jai Prakash Engineered Therapeutics Group, Department of Biomaterials Science and Technology, University of Twente, Enschede, The NetherlandsCorrespondence: Jai PrakashEngineered Therapeutics, Department of Biomaterials Science and Technology, University of Twente, Drienerlolaan 5, Enschede, 7500AE, The NetherlandsTel +31 53 4893096Email j.prakash@utwente.nlAbstract: Pancreatic cancer is one of the most malignant tumors with one of the worst survival rates due to its insidious onset and resistance to therapies. Most therapeutics show a desired anticancer effect in vitro; however, very poor efficacy in vivo because of the limited drug delivery and penetration into pancreatic tumors attributed to the abundance of the tumor stroma, ie, the fibrotic tumor microenvironment surrounding the cancer cells. For a better understanding of the challenges posed by the pancreatic tumor stroma, we outline the key features of the tumor microenvironment. Then we highlight major strategies used to tackle the challenges to improve drug penetration into the tumor and achieve enhanced efficacy (pre)clinically. Furthermore, we describe nanomedicine strategies to modulate the tumor stroma, degrade the extracellular matrix, and co-deliver multi-functional drugs, to improve the chemotherapeutics delivery and penetration into pancreatic tumors.Keywords: pancreatic ductal adenocarcinoma, cancer-associated fibroblasts, tumor stroma, tumor vasculature, drug perfusion, drug penetrationLu TPrakash JDove Medical Pressarticlepancreatic ductal adenocarcinomacancer-associated fibroblaststumor stromatumor vasculaturedrug perfusiondrug penetrationMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 16, Pp 6313-6328 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pancreatic ductal adenocarcinoma cancer-associated fibroblasts tumor stroma tumor vasculature drug perfusion drug penetration Medicine (General) R5-920
spellingShingle	pancreatic ductal adenocarcinoma cancer-associated fibroblasts tumor stroma tumor vasculature drug perfusion drug penetration Medicine (General) R5-920 Lu T Prakash J Nanomedicine Strategies to Enhance Tumor Drug Penetration in Pancreatic Cancer
description	Tao Lu, Jai Prakash Engineered Therapeutics Group, Department of Biomaterials Science and Technology, University of Twente, Enschede, The NetherlandsCorrespondence: Jai PrakashEngineered Therapeutics, Department of Biomaterials Science and Technology, University of Twente, Drienerlolaan 5, Enschede, 7500AE, The NetherlandsTel +31 53 4893096Email j.prakash@utwente.nlAbstract: Pancreatic cancer is one of the most malignant tumors with one of the worst survival rates due to its insidious onset and resistance to therapies. Most therapeutics show a desired anticancer effect in vitro; however, very poor efficacy in vivo because of the limited drug delivery and penetration into pancreatic tumors attributed to the abundance of the tumor stroma, ie, the fibrotic tumor microenvironment surrounding the cancer cells. For a better understanding of the challenges posed by the pancreatic tumor stroma, we outline the key features of the tumor microenvironment. Then we highlight major strategies used to tackle the challenges to improve drug penetration into the tumor and achieve enhanced efficacy (pre)clinically. Furthermore, we describe nanomedicine strategies to modulate the tumor stroma, degrade the extracellular matrix, and co-deliver multi-functional drugs, to improve the chemotherapeutics delivery and penetration into pancreatic tumors.Keywords: pancreatic ductal adenocarcinoma, cancer-associated fibroblasts, tumor stroma, tumor vasculature, drug perfusion, drug penetration
format	article
author	Lu T Prakash J
author_facet	Lu T Prakash J
author_sort	Lu T
title	Nanomedicine Strategies to Enhance Tumor Drug Penetration in Pancreatic Cancer
title_short	Nanomedicine Strategies to Enhance Tumor Drug Penetration in Pancreatic Cancer
title_full	Nanomedicine Strategies to Enhance Tumor Drug Penetration in Pancreatic Cancer
title_fullStr	Nanomedicine Strategies to Enhance Tumor Drug Penetration in Pancreatic Cancer
title_full_unstemmed	Nanomedicine Strategies to Enhance Tumor Drug Penetration in Pancreatic Cancer
title_sort	nanomedicine strategies to enhance tumor drug penetration in pancreatic cancer
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/016ad452d5cc4d7e982d295a6d6df70b
work_keys_str_mv	AT lut nanomedicinestrategiestoenhancetumordrugpenetrationinpancreaticcancer AT prakashj nanomedicinestrategiestoenhancetumordrugpenetrationinpancreaticcancer
_version_	1718380946794741760

Nanomedicine Strategies to Enhance Tumor Drug Penetration in Pancreatic Cancer

Ejemplares similares