Identification of the Pyroptosis-Related Gene Signature for Overall Survival Prediction in Patients With Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is the second most lethal malignant tumor worldwide, with an increasing incidence and mortality. Due to general resistance to antitumor drugs, only limited therapies are currently available for advanced HCC patients, leading to a poor prognosis with a 5-year survival r...

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Autores principales:	Shuang Liu, Ruonan Shao, Xiaoyun Bu, Yujie Xu, Ming Shi
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	pyroptosis prognosis prediction overall survival hepatocellular carcinoma immune infiltration Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/016ad88ef5534631aed70e9b7b1d2c79
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spelling	oai:doaj.org-article:016ad88ef5534631aed70e9b7b1d2c792021-11-08T05:15:55ZIdentification of the Pyroptosis-Related Gene Signature for Overall Survival Prediction in Patients With Hepatocellular Carcinoma2296-634X10.3389/fcell.2021.742994https://doaj.org/article/016ad88ef5534631aed70e9b7b1d2c792021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.742994/fullhttps://doaj.org/toc/2296-634XHepatocellular carcinoma (HCC) is the second most lethal malignant tumor worldwide, with an increasing incidence and mortality. Due to general resistance to antitumor drugs, only limited therapies are currently available for advanced HCC patients, leading to a poor prognosis with a 5-year survival rate less than 20%. Pyroptosis is a type of inflammation-related programmed cell death and may become a new potential target for cancer therapy. However, the function and prognostic value of pyroptosis-related genes (PRGs) in HCC remain unknown. Here, we identified a total of 58 PRGs reported before and conducted a six-PRG signature via the LASSO regression method in the GEO training cohort, and model efficacy was further validated in an external dataset. The HCC patients can be classified into two subgroups based on the median risk score. High-risk patients have significantly shorter overall survival (OS) than low-risk patients in both training and validation cohorts. Multivariable analysis indicated that the risk score was an independent prognostic factor for OS of HCC patients. Functional enrichment analysis and immune infiltration evaluation suggested that immune status was more activated in the low-risk group. In summary, PRGs can be a prediction factor for prognosis of HCC patients and targeting pyroptosis is a potential therapeutic alternative in HCC.Shuang LiuShuang LiuRuonan ShaoRuonan ShaoXiaoyun BuXiaoyun BuYujie XuYujie XuMing ShiMing ShiFrontiers Media S.A.articlepyroptosisprognosis predictionoverall survivalhepatocellular carcinomaimmune infiltrationBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pyroptosis prognosis prediction overall survival hepatocellular carcinoma immune infiltration Biology (General) QH301-705.5
spellingShingle	pyroptosis prognosis prediction overall survival hepatocellular carcinoma immune infiltration Biology (General) QH301-705.5 Shuang Liu Shuang Liu Ruonan Shao Ruonan Shao Xiaoyun Bu Xiaoyun Bu Yujie Xu Yujie Xu Ming Shi Ming Shi Identification of the Pyroptosis-Related Gene Signature for Overall Survival Prediction in Patients With Hepatocellular Carcinoma
description	Hepatocellular carcinoma (HCC) is the second most lethal malignant tumor worldwide, with an increasing incidence and mortality. Due to general resistance to antitumor drugs, only limited therapies are currently available for advanced HCC patients, leading to a poor prognosis with a 5-year survival rate less than 20%. Pyroptosis is a type of inflammation-related programmed cell death and may become a new potential target for cancer therapy. However, the function and prognostic value of pyroptosis-related genes (PRGs) in HCC remain unknown. Here, we identified a total of 58 PRGs reported before and conducted a six-PRG signature via the LASSO regression method in the GEO training cohort, and model efficacy was further validated in an external dataset. The HCC patients can be classified into two subgroups based on the median risk score. High-risk patients have significantly shorter overall survival (OS) than low-risk patients in both training and validation cohorts. Multivariable analysis indicated that the risk score was an independent prognostic factor for OS of HCC patients. Functional enrichment analysis and immune infiltration evaluation suggested that immune status was more activated in the low-risk group. In summary, PRGs can be a prediction factor for prognosis of HCC patients and targeting pyroptosis is a potential therapeutic alternative in HCC.
format	article
author	Shuang Liu Shuang Liu Ruonan Shao Ruonan Shao Xiaoyun Bu Xiaoyun Bu Yujie Xu Yujie Xu Ming Shi Ming Shi
author_facet	Shuang Liu Shuang Liu Ruonan Shao Ruonan Shao Xiaoyun Bu Xiaoyun Bu Yujie Xu Yujie Xu Ming Shi Ming Shi
author_sort	Shuang Liu
title	Identification of the Pyroptosis-Related Gene Signature for Overall Survival Prediction in Patients With Hepatocellular Carcinoma
title_short	Identification of the Pyroptosis-Related Gene Signature for Overall Survival Prediction in Patients With Hepatocellular Carcinoma
title_full	Identification of the Pyroptosis-Related Gene Signature for Overall Survival Prediction in Patients With Hepatocellular Carcinoma
title_fullStr	Identification of the Pyroptosis-Related Gene Signature for Overall Survival Prediction in Patients With Hepatocellular Carcinoma
title_full_unstemmed	Identification of the Pyroptosis-Related Gene Signature for Overall Survival Prediction in Patients With Hepatocellular Carcinoma
title_sort	identification of the pyroptosis-related gene signature for overall survival prediction in patients with hepatocellular carcinoma
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/016ad88ef5534631aed70e9b7b1d2c79
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Identification of the Pyroptosis-Related Gene Signature for Overall Survival Prediction in Patients With Hepatocellular Carcinoma

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