BRG1-SWI/SNF-dependent regulation of the Wt1 transcriptional landscape mediates epicardial activity during heart development and disease

Priming of the adult mouse heart with Tβ4 activates dormant epicardium-derived cells to aid repair of injured myocardium. Here, Vieiraet al. explain this process and show that Tβ4 binds a chromatin remodeller BRG1 and activates Wt1, the key regulator of epicardial epithelial-to-mesenchymal transform...

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Autores principales:	Joaquim Miguel Vieira, Sara Howard, Cristina Villa del Campo, Sveva Bollini, Karina N. Dubé, Megan Masters, Damien N. Barnette, Mala Rohling, Xin Sun, Laura E. Hankins, Daria Gavriouchkina, Ruth Williams, Daniel Metzger, Pierre Chambon, Tatjana Sauka-Spengler, Benjamin Davies, Paul R. Riley
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/016d532aec994a92bc77e854190df861
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spelling	oai:doaj.org-article:016d532aec994a92bc77e854190df8612021-12-02T17:06:14ZBRG1-SWI/SNF-dependent regulation of the Wt1 transcriptional landscape mediates epicardial activity during heart development and disease10.1038/ncomms160342041-1723https://doaj.org/article/016d532aec994a92bc77e854190df8612017-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms16034https://doaj.org/toc/2041-1723Priming of the adult mouse heart with Tβ4 activates dormant epicardium-derived cells to aid repair of injured myocardium. Here, Vieiraet al. explain this process and show that Tβ4 binds a chromatin remodeller BRG1 and activates Wt1, the key regulator of epicardial epithelial-to-mesenchymal transformation, by altering the epigenetic landscape of the Wt1 locus.Joaquim Miguel VieiraSara HowardCristina Villa del CampoSveva BolliniKarina N. DubéMegan MastersDamien N. BarnetteMala RohlingXin SunLaura E. HankinsDaria GavriouchkinaRuth WilliamsDaniel MetzgerPierre ChambonTatjana Sauka-SpenglerBenjamin DaviesPaul R. RileyNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joaquim Miguel Vieira Sara Howard Cristina Villa del Campo Sveva Bollini Karina N. Dubé Megan Masters Damien N. Barnette Mala Rohling Xin Sun Laura E. Hankins Daria Gavriouchkina Ruth Williams Daniel Metzger Pierre Chambon Tatjana Sauka-Spengler Benjamin Davies Paul R. Riley BRG1-SWI/SNF-dependent regulation of the Wt1 transcriptional landscape mediates epicardial activity during heart development and disease
description	Priming of the adult mouse heart with Tβ4 activates dormant epicardium-derived cells to aid repair of injured myocardium. Here, Vieiraet al. explain this process and show that Tβ4 binds a chromatin remodeller BRG1 and activates Wt1, the key regulator of epicardial epithelial-to-mesenchymal transformation, by altering the epigenetic landscape of the Wt1 locus.
format	article
author	Joaquim Miguel Vieira Sara Howard Cristina Villa del Campo Sveva Bollini Karina N. Dubé Megan Masters Damien N. Barnette Mala Rohling Xin Sun Laura E. Hankins Daria Gavriouchkina Ruth Williams Daniel Metzger Pierre Chambon Tatjana Sauka-Spengler Benjamin Davies Paul R. Riley
author_facet	Joaquim Miguel Vieira Sara Howard Cristina Villa del Campo Sveva Bollini Karina N. Dubé Megan Masters Damien N. Barnette Mala Rohling Xin Sun Laura E. Hankins Daria Gavriouchkina Ruth Williams Daniel Metzger Pierre Chambon Tatjana Sauka-Spengler Benjamin Davies Paul R. Riley
author_sort	Joaquim Miguel Vieira
title	BRG1-SWI/SNF-dependent regulation of the Wt1 transcriptional landscape mediates epicardial activity during heart development and disease
title_short	BRG1-SWI/SNF-dependent regulation of the Wt1 transcriptional landscape mediates epicardial activity during heart development and disease
title_full	BRG1-SWI/SNF-dependent regulation of the Wt1 transcriptional landscape mediates epicardial activity during heart development and disease
title_fullStr	BRG1-SWI/SNF-dependent regulation of the Wt1 transcriptional landscape mediates epicardial activity during heart development and disease
title_full_unstemmed	BRG1-SWI/SNF-dependent regulation of the Wt1 transcriptional landscape mediates epicardial activity during heart development and disease
title_sort	brg1-swi/snf-dependent regulation of the wt1 transcriptional landscape mediates epicardial activity during heart development and disease
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/016d532aec994a92bc77e854190df861
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BRG1-SWI/SNF-dependent regulation of the Wt1 transcriptional landscape mediates epicardial activity during heart development and disease

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