GWAS for quantitative resistance phenotypes in Mycobacterium tuberculosis reveals resistance genes and regulatory regions

GWAS for quantitative resistance phenotypes in Mycobacterium tuberculosis reveals resistance genes and regulatory regions

Resistance to antibiotics hampers the treatment of infectious diseases such as tuberculosis (TB). Here, Farhat et al. perform genome-wide association testing for minimum inhibitory concentration (MIC) of 12 anti-TB drugs in whole-genome sequenced clinical M. tuberculosis isolates and identify 13 gen...

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Autores principales: Maha R. Farhat, Luca Freschi, Roger Calderon, Thomas Ioerger, Matthew Snyder, Conor J. Meehan, Bouke de Jong, Leen Rigouts, Alex Sloutsky, Devinder Kaur, Shamil Sunyaev, Dick van Soolingen, Jay Shendure, Jim Sacchettini, Megan Murray
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/016ec14802424226be7595c42ca7b257
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Sumario:Resistance to antibiotics hampers the treatment of infectious diseases such as tuberculosis (TB). Here, Farhat et al. perform genome-wide association testing for minimum inhibitory concentration (MIC) of 12 anti-TB drugs in whole-genome sequenced clinical M. tuberculosis isolates and identify 13 genomic loci.

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