Recent advances of fluorescent biosensors based on cyclic signal amplification technology in biomedical detection

Abstract The cyclic signal amplification technology has been widely applied for the ultrasensitive detection of many important biomolecules, such as nucleic acids, proteins, enzymes, adenosine triphosphate (ATP), metal ions, exosome, etc. Due to their low content in the complex biological samples, t...

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Autores principales:	Hongke Qu, Chunmei Fan, Mingjian Chen, Xiangyan Zhang, Qijia Yan, Yumin Wang, Shanshan Zhang, Zhaojian Gong, Lei Shi, Xiayu Li, Qianjin Liao, Bo Xiang, Ming Zhou, Can Guo, Guiyuan Li, Zhaoyang Zeng, Xu Wu, Wei Xiong
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Fluorescence biosensor Cyclic signal amplification Biomedical detection Biotechnology TP248.13-248.65 Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/016f8b76c52d43d5b56091e6f4f22d9b
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spelling	oai:doaj.org-article:016f8b76c52d43d5b56091e6f4f22d9b2021-12-05T12:19:09ZRecent advances of fluorescent biosensors based on cyclic signal amplification technology in biomedical detection10.1186/s12951-021-01149-z1477-3155https://doaj.org/article/016f8b76c52d43d5b56091e6f4f22d9b2021-12-01T00:00:00Zhttps://doi.org/10.1186/s12951-021-01149-zhttps://doaj.org/toc/1477-3155Abstract The cyclic signal amplification technology has been widely applied for the ultrasensitive detection of many important biomolecules, such as nucleic acids, proteins, enzymes, adenosine triphosphate (ATP), metal ions, exosome, etc. Due to their low content in the complex biological samples, traditional detection methods are insufficient to satisfy the requirements for monitoring those biomolecules. Therefore, effective and sensitive biosensors based on cyclic signal amplification technology are of great significance for the quick and simple diagnosis and treatment of diseases. Fluorescent biosensor based on cyclic signal amplification technology has become a research hotspot due to its simple operation, low cost, short time, high sensitivity and high specificity. This paper introduces several cyclic amplification methods, such as rolling circle amplification (RCA), strand displacement reactions (SDR) and enzyme-assisted amplification (EAA), and summarizes the research progress of using this technology in the detection of different biomolecules in recent years, in order to provide help for the research of more efficient and sensitive detection methods. Graphical AbstractHongke QuChunmei FanMingjian ChenXiangyan ZhangQijia YanYumin WangShanshan ZhangZhaojian GongLei ShiXiayu LiQianjin LiaoBo XiangMing ZhouCan GuoGuiyuan LiZhaoyang ZengXu WuWei XiongBMCarticleFluorescence biosensorCyclic signal amplificationBiomedical detectionBiotechnologyTP248.13-248.65Medical technologyR855-855.5ENJournal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-28 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Fluorescence biosensor Cyclic signal amplification Biomedical detection Biotechnology TP248.13-248.65 Medical technology R855-855.5
spellingShingle	Fluorescence biosensor Cyclic signal amplification Biomedical detection Biotechnology TP248.13-248.65 Medical technology R855-855.5 Hongke Qu Chunmei Fan Mingjian Chen Xiangyan Zhang Qijia Yan Yumin Wang Shanshan Zhang Zhaojian Gong Lei Shi Xiayu Li Qianjin Liao Bo Xiang Ming Zhou Can Guo Guiyuan Li Zhaoyang Zeng Xu Wu Wei Xiong Recent advances of fluorescent biosensors based on cyclic signal amplification technology in biomedical detection
description	Abstract The cyclic signal amplification technology has been widely applied for the ultrasensitive detection of many important biomolecules, such as nucleic acids, proteins, enzymes, adenosine triphosphate (ATP), metal ions, exosome, etc. Due to their low content in the complex biological samples, traditional detection methods are insufficient to satisfy the requirements for monitoring those biomolecules. Therefore, effective and sensitive biosensors based on cyclic signal amplification technology are of great significance for the quick and simple diagnosis and treatment of diseases. Fluorescent biosensor based on cyclic signal amplification technology has become a research hotspot due to its simple operation, low cost, short time, high sensitivity and high specificity. This paper introduces several cyclic amplification methods, such as rolling circle amplification (RCA), strand displacement reactions (SDR) and enzyme-assisted amplification (EAA), and summarizes the research progress of using this technology in the detection of different biomolecules in recent years, in order to provide help for the research of more efficient and sensitive detection methods. Graphical Abstract
format	article
author	Hongke Qu Chunmei Fan Mingjian Chen Xiangyan Zhang Qijia Yan Yumin Wang Shanshan Zhang Zhaojian Gong Lei Shi Xiayu Li Qianjin Liao Bo Xiang Ming Zhou Can Guo Guiyuan Li Zhaoyang Zeng Xu Wu Wei Xiong
author_facet	Hongke Qu Chunmei Fan Mingjian Chen Xiangyan Zhang Qijia Yan Yumin Wang Shanshan Zhang Zhaojian Gong Lei Shi Xiayu Li Qianjin Liao Bo Xiang Ming Zhou Can Guo Guiyuan Li Zhaoyang Zeng Xu Wu Wei Xiong
author_sort	Hongke Qu
title	Recent advances of fluorescent biosensors based on cyclic signal amplification technology in biomedical detection
title_short	Recent advances of fluorescent biosensors based on cyclic signal amplification technology in biomedical detection
title_full	Recent advances of fluorescent biosensors based on cyclic signal amplification technology in biomedical detection
title_fullStr	Recent advances of fluorescent biosensors based on cyclic signal amplification technology in biomedical detection
title_full_unstemmed	Recent advances of fluorescent biosensors based on cyclic signal amplification technology in biomedical detection
title_sort	recent advances of fluorescent biosensors based on cyclic signal amplification technology in biomedical detection
publisher	BMC
publishDate	2021
url	https://doaj.org/article/016f8b76c52d43d5b56091e6f4f22d9b
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Recent advances of fluorescent biosensors based on cyclic signal amplification technology in biomedical detection

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