Effects of Topically Applied Betulinic Acid and NVX-207 on Melanocytic Tumors in 18 Horses

The naturally occurring betulinic acid (BA) and its derivative NVX-207 induce apoptosis in equine melanoma cells in vitro. After topical application, high concentrations of the substances can be reached in healthy equine skin. With the aim to investigate the effect and safety of topically applied BA...

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Autores principales:	Lisa A. Weber, Julien Delarocque, Karsten Feige, Manfred Kietzmann, Jutta Kalbitz, Jessica Meißner, Reinhard Paschke, Jessika-M. V. Cavalleri
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	equine melanocytic tumor horse oncology skin neoplasia topical drug triterpenoids Veterinary medicine SF600-1100 Zoology QL1-991
Acceso en línea:	https://doaj.org/article/017442e3a3654964bca3c43be08fd459
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spelling	oai:doaj.org-article:017442e3a3654964bca3c43be08fd4592021-11-25T16:19:50ZEffects of Topically Applied Betulinic Acid and NVX-207 on Melanocytic Tumors in 18 Horses10.3390/ani111132502076-2615https://doaj.org/article/017442e3a3654964bca3c43be08fd4592021-11-01T00:00:00Zhttps://www.mdpi.com/2076-2615/11/11/3250https://doaj.org/toc/2076-2615The naturally occurring betulinic acid (BA) and its derivative NVX-207 induce apoptosis in equine melanoma cells in vitro. After topical application, high concentrations of the substances can be reached in healthy equine skin. With the aim to investigate the effect and safety of topically applied BA and NVX-207 in horses with melanocytic tumors, the longitudinal, prospective, randomized, double-blind, placebo-controlled study protocol included eighteen Lipizzaner mares with early-stage cutaneous melanoma assigned to three groups. Melanocytic lesions were topically treated either with a placebo, 1% BA or 1% NVX-207 twice a day for 91 days. Caliper measurements, clinical examinations and blood tests were performed to assess the effects and safety of the medication. The topical treatment was convenient and safe. The volumes of tumors treated with BA were significantly reduced over time as compared to tumors treated with the placebo from day 80 of the study. Although treatment with NVX-207 seemed to decrease tumor volume, these results did not reach statistical significance. The findings must be regarded as preliminary due to the limited group size and need to be replicated in a larger cohort with modified pharmaceutical test formulations. Accordingly, the treatment protocol cannot yet be recommended in its current form.Lisa A. WeberJulien DelarocqueKarsten FeigeManfred KietzmannJutta KalbitzJessica MeißnerReinhard PaschkeJessika-M. V. CavalleriMDPI AGarticleequine melanocytic tumorhorseoncologyskin neoplasiatopical drugtriterpenoidsVeterinary medicineSF600-1100ZoologyQL1-991ENAnimals, Vol 11, Iss 3250, p 3250 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	equine melanocytic tumor horse oncology skin neoplasia topical drug triterpenoids Veterinary medicine SF600-1100 Zoology QL1-991
spellingShingle	equine melanocytic tumor horse oncology skin neoplasia topical drug triterpenoids Veterinary medicine SF600-1100 Zoology QL1-991 Lisa A. Weber Julien Delarocque Karsten Feige Manfred Kietzmann Jutta Kalbitz Jessica Meißner Reinhard Paschke Jessika-M. V. Cavalleri Effects of Topically Applied Betulinic Acid and NVX-207 on Melanocytic Tumors in 18 Horses
description	The naturally occurring betulinic acid (BA) and its derivative NVX-207 induce apoptosis in equine melanoma cells in vitro. After topical application, high concentrations of the substances can be reached in healthy equine skin. With the aim to investigate the effect and safety of topically applied BA and NVX-207 in horses with melanocytic tumors, the longitudinal, prospective, randomized, double-blind, placebo-controlled study protocol included eighteen Lipizzaner mares with early-stage cutaneous melanoma assigned to three groups. Melanocytic lesions were topically treated either with a placebo, 1% BA or 1% NVX-207 twice a day for 91 days. Caliper measurements, clinical examinations and blood tests were performed to assess the effects and safety of the medication. The topical treatment was convenient and safe. The volumes of tumors treated with BA were significantly reduced over time as compared to tumors treated with the placebo from day 80 of the study. Although treatment with NVX-207 seemed to decrease tumor volume, these results did not reach statistical significance. The findings must be regarded as preliminary due to the limited group size and need to be replicated in a larger cohort with modified pharmaceutical test formulations. Accordingly, the treatment protocol cannot yet be recommended in its current form.
format	article
author	Lisa A. Weber Julien Delarocque Karsten Feige Manfred Kietzmann Jutta Kalbitz Jessica Meißner Reinhard Paschke Jessika-M. V. Cavalleri
author_facet	Lisa A. Weber Julien Delarocque Karsten Feige Manfred Kietzmann Jutta Kalbitz Jessica Meißner Reinhard Paschke Jessika-M. V. Cavalleri
author_sort	Lisa A. Weber
title	Effects of Topically Applied Betulinic Acid and NVX-207 on Melanocytic Tumors in 18 Horses
title_short	Effects of Topically Applied Betulinic Acid and NVX-207 on Melanocytic Tumors in 18 Horses
title_full	Effects of Topically Applied Betulinic Acid and NVX-207 on Melanocytic Tumors in 18 Horses
title_fullStr	Effects of Topically Applied Betulinic Acid and NVX-207 on Melanocytic Tumors in 18 Horses
title_full_unstemmed	Effects of Topically Applied Betulinic Acid and NVX-207 on Melanocytic Tumors in 18 Horses
title_sort	effects of topically applied betulinic acid and nvx-207 on melanocytic tumors in 18 horses
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/017442e3a3654964bca3c43be08fd459
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Effects of Topically Applied Betulinic Acid and NVX-207 on Melanocytic Tumors in 18 Horses

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