Genome-wide insights into population structure and host specificity of Campylobacter jejuni

Abstract The zoonotic pathogen Campylobacter jejuni is among the leading causes of foodborne diseases worldwide. While C. jejuni colonises many wild animals and livestock, persistence mechanisms enabling the bacterium to adapt to host species' guts are not fully understood. In order to identify...

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Autores principales:	Lennard Epping, Birgit Walther, Rosario M. Piro, Marie-Theres Knüver, Charlotte Huber, Andrea Thürmer, Antje Flieger, Angelika Fruth, Nicol Janecko, Lothar H. Wieler, Kerstin Stingl, Torsten Semmler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/01756064974941f0a48fdbab017e3455
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spelling	oai:doaj.org-article:01756064974941f0a48fdbab017e34552021-12-02T16:50:22ZGenome-wide insights into population structure and host specificity of Campylobacter jejuni10.1038/s41598-021-89683-62045-2322https://doaj.org/article/01756064974941f0a48fdbab017e34552021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89683-6https://doaj.org/toc/2045-2322Abstract The zoonotic pathogen Campylobacter jejuni is among the leading causes of foodborne diseases worldwide. While C. jejuni colonises many wild animals and livestock, persistence mechanisms enabling the bacterium to adapt to host species' guts are not fully understood. In order to identify putative determinants influencing host preferences of distinct lineages, bootstrapping based on stratified random sampling combined with a k-mer-based genome-wide association was conducted on 490 genomes from diverse origins in Germany and Canada. We show a strong association of both the core and the accessory genome characteristics with distinct host animal species, indicating multiple adaptive trajectories defining the evolution of C. jejuni lifestyle preferences in different ecosystems. Here, we demonstrate that adaptation towards a specific host niche ecology is most likely a long evolutionary and multifactorial process, expressed by gene absence or presence and allele variations of core genes. Several host-specific allelic variants from different phylogenetic backgrounds, including dnaE, rpoB, ftsX or pycB play important roles for genome maintenance and metabolic pathways. Thus, variants of genes important for C. jejuni to cope with specific ecological niches or hosts may be useful markers for both surveillance and future pathogen intervention strategies.Lennard EppingBirgit WaltherRosario M. PiroMarie-Theres KnüverCharlotte HuberAndrea ThürmerAntje FliegerAngelika FruthNicol JaneckoLothar H. WielerKerstin StinglTorsten SemmlerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lennard Epping Birgit Walther Rosario M. Piro Marie-Theres Knüver Charlotte Huber Andrea Thürmer Antje Flieger Angelika Fruth Nicol Janecko Lothar H. Wieler Kerstin Stingl Torsten Semmler Genome-wide insights into population structure and host specificity of Campylobacter jejuni
description	Abstract The zoonotic pathogen Campylobacter jejuni is among the leading causes of foodborne diseases worldwide. While C. jejuni colonises many wild animals and livestock, persistence mechanisms enabling the bacterium to adapt to host species' guts are not fully understood. In order to identify putative determinants influencing host preferences of distinct lineages, bootstrapping based on stratified random sampling combined with a k-mer-based genome-wide association was conducted on 490 genomes from diverse origins in Germany and Canada. We show a strong association of both the core and the accessory genome characteristics with distinct host animal species, indicating multiple adaptive trajectories defining the evolution of C. jejuni lifestyle preferences in different ecosystems. Here, we demonstrate that adaptation towards a specific host niche ecology is most likely a long evolutionary and multifactorial process, expressed by gene absence or presence and allele variations of core genes. Several host-specific allelic variants from different phylogenetic backgrounds, including dnaE, rpoB, ftsX or pycB play important roles for genome maintenance and metabolic pathways. Thus, variants of genes important for C. jejuni to cope with specific ecological niches or hosts may be useful markers for both surveillance and future pathogen intervention strategies.
format	article
author	Lennard Epping Birgit Walther Rosario M. Piro Marie-Theres Knüver Charlotte Huber Andrea Thürmer Antje Flieger Angelika Fruth Nicol Janecko Lothar H. Wieler Kerstin Stingl Torsten Semmler
author_facet	Lennard Epping Birgit Walther Rosario M. Piro Marie-Theres Knüver Charlotte Huber Andrea Thürmer Antje Flieger Angelika Fruth Nicol Janecko Lothar H. Wieler Kerstin Stingl Torsten Semmler
author_sort	Lennard Epping
title	Genome-wide insights into population structure and host specificity of Campylobacter jejuni
title_short	Genome-wide insights into population structure and host specificity of Campylobacter jejuni
title_full	Genome-wide insights into population structure and host specificity of Campylobacter jejuni
title_fullStr	Genome-wide insights into population structure and host specificity of Campylobacter jejuni
title_full_unstemmed	Genome-wide insights into population structure and host specificity of Campylobacter jejuni
title_sort	genome-wide insights into population structure and host specificity of campylobacter jejuni
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/01756064974941f0a48fdbab017e3455
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Genome-wide insights into population structure and host specificity of Campylobacter jejuni

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