Anti-chikungunya virus seroprevalence in Indigenous groups in the São Francisco Valley, Brazil.

<h4>Background</h4>Chikungunya fever (CHIKF) is a serious public health problem with a high rate of infection and chronic disabling manifestations that has affected more than 2 million people worldwide since 2005. In spite of this, epidemiological data on vulnerable groups such as Indige...

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Autores principales:	Jandir Mendonça Nicacio, Ricardo Khouri, Antônio Marconi Leandro da Silva, Manoel Barral-Netto, João Augusto Costa Lima, Ana Marice Teixeira Ladeia, Rodrigo Feliciano do Carmo, Anderson da Costa Armstrong
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/0177bb316df24b108e525713dbb7165d
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spelling	oai:doaj.org-article:0177bb316df24b108e525713dbb7165d2021-11-25T06:33:07ZAnti-chikungunya virus seroprevalence in Indigenous groups in the São Francisco Valley, Brazil.1935-27271935-273510.1371/journal.pntd.0009468https://doaj.org/article/0177bb316df24b108e525713dbb7165d2021-06-01T00:00:00Zhttps://doi.org/10.1371/journal.pntd.0009468https://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735<h4>Background</h4>Chikungunya fever (CHIKF) is a serious public health problem with a high rate of infection and chronic disabling manifestations that has affected more than 2 million people worldwide since 2005. In spite of this, epidemiological data on vulnerable groups such as Indigenous people are scarce, making it difficult to implement public policies in order to prevent this disease and assist these populations.<h4>Objective</h4>To describe the serological and epidemiological profile of chikungunya virus (CHIKV) in two Indigenous populations in Northeast Brazil, as well as in an urbanized control community, and to explore associations between CHIKV and anthropometric variables in these populations.<h4>Methodology/principal findings</h4>This is a cross-sectional ancillary study of the Project of Atherosclerosis among Indigenous Populations (PAI) that included people 30 to 70 years old, recruited from two Indigenous tribes (the less urbanized Fulni-ô and the more urbanized Truká people) and an urbanized non-Indigenous control group from the same area. Subjects underwent clinical evaluation and were tested for anti-CHIKV IgG by enzyme-linked immunosorbent assay. Serological profile was described according to ethnicity, sex, and age. The study population included 433 individuals distributed as follows: 109 (25·2%) Truká, 272 (62·8%) Fulni-ô, and 52 (12%) from the non-Indigenous urbanized control group. Overall prevalence of CHIKV IgG in the study sample was 49.9% (216; 95% CI: 45·1-54·7). When the sample was stratified, positive CHIKV IgG was distributed as follows: no individuals in the Truká group, 78·3% (213/272; 95% CI: 72·9-83·1) in the Fulni-ô group, and 5.8% (3/52; 95% CI: 1.21-16) in the control group.<h4>Conclusions/significance</h4>Positive tests for CHIKV showed a very high prevalence in a traditional Indigenous population, in contrast to the absence of anti-CHIKV serology in the Truká people, who are more urbanized with respect to physical landscape, socio-cultural, and historical aspects, as well as a low prevalence in the non-Indigenous control group, although all groups are located in the same area.Jandir Mendonça NicacioRicardo KhouriAntônio Marconi Leandro da SilvaManoel Barral-NettoJoão Augusto Costa LimaAna Marice Teixeira LadeiaRodrigo Feliciano do CarmoAnderson da Costa ArmstrongPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 15, Iss 6, p e0009468 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Jandir Mendonça Nicacio Ricardo Khouri Antônio Marconi Leandro da Silva Manoel Barral-Netto João Augusto Costa Lima Ana Marice Teixeira Ladeia Rodrigo Feliciano do Carmo Anderson da Costa Armstrong Anti-chikungunya virus seroprevalence in Indigenous groups in the São Francisco Valley, Brazil.
description	<h4>Background</h4>Chikungunya fever (CHIKF) is a serious public health problem with a high rate of infection and chronic disabling manifestations that has affected more than 2 million people worldwide since 2005. In spite of this, epidemiological data on vulnerable groups such as Indigenous people are scarce, making it difficult to implement public policies in order to prevent this disease and assist these populations.<h4>Objective</h4>To describe the serological and epidemiological profile of chikungunya virus (CHIKV) in two Indigenous populations in Northeast Brazil, as well as in an urbanized control community, and to explore associations between CHIKV and anthropometric variables in these populations.<h4>Methodology/principal findings</h4>This is a cross-sectional ancillary study of the Project of Atherosclerosis among Indigenous Populations (PAI) that included people 30 to 70 years old, recruited from two Indigenous tribes (the less urbanized Fulni-ô and the more urbanized Truká people) and an urbanized non-Indigenous control group from the same area. Subjects underwent clinical evaluation and were tested for anti-CHIKV IgG by enzyme-linked immunosorbent assay. Serological profile was described according to ethnicity, sex, and age. The study population included 433 individuals distributed as follows: 109 (25·2%) Truká, 272 (62·8%) Fulni-ô, and 52 (12%) from the non-Indigenous urbanized control group. Overall prevalence of CHIKV IgG in the study sample was 49.9% (216; 95% CI: 45·1-54·7). When the sample was stratified, positive CHIKV IgG was distributed as follows: no individuals in the Truká group, 78·3% (213/272; 95% CI: 72·9-83·1) in the Fulni-ô group, and 5.8% (3/52; 95% CI: 1.21-16) in the control group.<h4>Conclusions/significance</h4>Positive tests for CHIKV showed a very high prevalence in a traditional Indigenous population, in contrast to the absence of anti-CHIKV serology in the Truká people, who are more urbanized with respect to physical landscape, socio-cultural, and historical aspects, as well as a low prevalence in the non-Indigenous control group, although all groups are located in the same area.
format	article
author	Jandir Mendonça Nicacio Ricardo Khouri Antônio Marconi Leandro da Silva Manoel Barral-Netto João Augusto Costa Lima Ana Marice Teixeira Ladeia Rodrigo Feliciano do Carmo Anderson da Costa Armstrong
author_facet	Jandir Mendonça Nicacio Ricardo Khouri Antônio Marconi Leandro da Silva Manoel Barral-Netto João Augusto Costa Lima Ana Marice Teixeira Ladeia Rodrigo Feliciano do Carmo Anderson da Costa Armstrong
author_sort	Jandir Mendonça Nicacio
title	Anti-chikungunya virus seroprevalence in Indigenous groups in the São Francisco Valley, Brazil.
title_short	Anti-chikungunya virus seroprevalence in Indigenous groups in the São Francisco Valley, Brazil.
title_full	Anti-chikungunya virus seroprevalence in Indigenous groups in the São Francisco Valley, Brazil.
title_fullStr	Anti-chikungunya virus seroprevalence in Indigenous groups in the São Francisco Valley, Brazil.
title_full_unstemmed	Anti-chikungunya virus seroprevalence in Indigenous groups in the São Francisco Valley, Brazil.
title_sort	anti-chikungunya virus seroprevalence in indigenous groups in the são francisco valley, brazil.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/0177bb316df24b108e525713dbb7165d
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Anti-chikungunya virus seroprevalence in Indigenous groups in the São Francisco Valley, Brazil.

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