Priming of lineage-specifying genes by Bcl11b is required for lineage choice in post-selection thymocytes

CD4 and CD8 T cells develop in the thymus with their transcription programs controlled by ThPOK and Runx3, respectively. Here the authors show that a pre-commitment event modulated by the transcription factor, Bcl11b, is required for the proper expression of ThPOK and Runx3 and correct CD4/CD8 linea...

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Autores principales:	Satoshi Kojo, Hirokazu Tanaka, Takaho A. Endo, Sawako Muroi, Ye Liu, Wooseok Seo, Mari Tenno, Kiyokazu Kakugawa, Yoshinori Naoe, Krutula Nair, Kazuyo Moro, Yoshinori Katsuragi, Akinori Kanai, Toshiya Inaba, Takeshi Egawa, Byrappa Venkatesh, Aki Minoda, Ryo Kominami, Ichiro Taniuchi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0177c41482984628992633de17614903
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spelling	oai:doaj.org-article:0177c41482984628992633de176149032021-12-02T17:06:24ZPriming of lineage-specifying genes by Bcl11b is required for lineage choice in post-selection thymocytes10.1038/s41467-017-00768-12041-1723https://doaj.org/article/0177c41482984628992633de176149032017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00768-1https://doaj.org/toc/2041-1723CD4 and CD8 T cells develop in the thymus with their transcription programs controlled by ThPOK and Runx3, respectively. Here the authors show that a pre-commitment event modulated by the transcription factor, Bcl11b, is required for the proper expression of ThPOK and Runx3 and correct CD4/CD8 lineage commitment.Satoshi KojoHirokazu TanakaTakaho A. EndoSawako MuroiYe LiuWooseok SeoMari TennoKiyokazu KakugawaYoshinori NaoeKrutula NairKazuyo MoroYoshinori KatsuragiAkinori KanaiToshiya InabaTakeshi EgawaByrappa VenkateshAki MinodaRyo KominamiIchiro TaniuchiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Satoshi Kojo Hirokazu Tanaka Takaho A. Endo Sawako Muroi Ye Liu Wooseok Seo Mari Tenno Kiyokazu Kakugawa Yoshinori Naoe Krutula Nair Kazuyo Moro Yoshinori Katsuragi Akinori Kanai Toshiya Inaba Takeshi Egawa Byrappa Venkatesh Aki Minoda Ryo Kominami Ichiro Taniuchi Priming of lineage-specifying genes by Bcl11b is required for lineage choice in post-selection thymocytes
description	CD4 and CD8 T cells develop in the thymus with their transcription programs controlled by ThPOK and Runx3, respectively. Here the authors show that a pre-commitment event modulated by the transcription factor, Bcl11b, is required for the proper expression of ThPOK and Runx3 and correct CD4/CD8 lineage commitment.
format	article
author	Satoshi Kojo Hirokazu Tanaka Takaho A. Endo Sawako Muroi Ye Liu Wooseok Seo Mari Tenno Kiyokazu Kakugawa Yoshinori Naoe Krutula Nair Kazuyo Moro Yoshinori Katsuragi Akinori Kanai Toshiya Inaba Takeshi Egawa Byrappa Venkatesh Aki Minoda Ryo Kominami Ichiro Taniuchi
author_facet	Satoshi Kojo Hirokazu Tanaka Takaho A. Endo Sawako Muroi Ye Liu Wooseok Seo Mari Tenno Kiyokazu Kakugawa Yoshinori Naoe Krutula Nair Kazuyo Moro Yoshinori Katsuragi Akinori Kanai Toshiya Inaba Takeshi Egawa Byrappa Venkatesh Aki Minoda Ryo Kominami Ichiro Taniuchi
author_sort	Satoshi Kojo
title	Priming of lineage-specifying genes by Bcl11b is required for lineage choice in post-selection thymocytes
title_short	Priming of lineage-specifying genes by Bcl11b is required for lineage choice in post-selection thymocytes
title_full	Priming of lineage-specifying genes by Bcl11b is required for lineage choice in post-selection thymocytes
title_fullStr	Priming of lineage-specifying genes by Bcl11b is required for lineage choice in post-selection thymocytes
title_full_unstemmed	Priming of lineage-specifying genes by Bcl11b is required for lineage choice in post-selection thymocytes
title_sort	priming of lineage-specifying genes by bcl11b is required for lineage choice in post-selection thymocytes
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0177c41482984628992633de17614903
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Priming of lineage-specifying genes by Bcl11b is required for lineage choice in post-selection thymocytes

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