Altered steady state and activity-dependent de novo protein expression in fragile X syndrome

Elevated protein synthesis, and dysregulated mGluR signalling, are documented in fragile X syndrome (FXS) Here the authors use proteomic analysis in a mouse model of FXS, and following mGluR5 stimulation, to identify potential biomarkers for the disease.

Guardado en:

Detalles Bibliográficos
Autores principales:	Heather Bowling, Aditi Bhattacharya, Guoan Zhang, Danyal Alam, Joseph Z. Lebowitz, Nathaniel Bohm-Levine, Derek Lin, Priyangvada Singha, Maggie Mamcarz, Rosemary Puckett, Lili Zhou, Sameer Aryal, Kevin Sharp, Kent Kirshenbaum, Elizabeth Berry-Kravis, Thomas A. Neubert, Eric Klann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0178bf18b8774f1ebc6d3278b69cc089
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0178bf18b8774f1ebc6d3278b69cc089
record_format	dspace
spelling	oai:doaj.org-article:0178bf18b8774f1ebc6d3278b69cc0892021-12-02T17:02:02ZAltered steady state and activity-dependent de novo protein expression in fragile X syndrome10.1038/s41467-019-09553-82041-1723https://doaj.org/article/0178bf18b8774f1ebc6d3278b69cc0892019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09553-8https://doaj.org/toc/2041-1723Elevated protein synthesis, and dysregulated mGluR signalling, are documented in fragile X syndrome (FXS) Here the authors use proteomic analysis in a mouse model of FXS, and following mGluR5 stimulation, to identify potential biomarkers for the disease.Heather BowlingAditi BhattacharyaGuoan ZhangDanyal AlamJoseph Z. LebowitzNathaniel Bohm-LevineDerek LinPriyangvada SinghaMaggie MamcarzRosemary PuckettLili ZhouSameer AryalKevin SharpKent KirshenbaumElizabeth Berry-KravisThomas A. NeubertEric KlannNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Heather Bowling Aditi Bhattacharya Guoan Zhang Danyal Alam Joseph Z. Lebowitz Nathaniel Bohm-Levine Derek Lin Priyangvada Singha Maggie Mamcarz Rosemary Puckett Lili Zhou Sameer Aryal Kevin Sharp Kent Kirshenbaum Elizabeth Berry-Kravis Thomas A. Neubert Eric Klann Altered steady state and activity-dependent de novo protein expression in fragile X syndrome
description	Elevated protein synthesis, and dysregulated mGluR signalling, are documented in fragile X syndrome (FXS) Here the authors use proteomic analysis in a mouse model of FXS, and following mGluR5 stimulation, to identify potential biomarkers for the disease.
format	article
author	Heather Bowling Aditi Bhattacharya Guoan Zhang Danyal Alam Joseph Z. Lebowitz Nathaniel Bohm-Levine Derek Lin Priyangvada Singha Maggie Mamcarz Rosemary Puckett Lili Zhou Sameer Aryal Kevin Sharp Kent Kirshenbaum Elizabeth Berry-Kravis Thomas A. Neubert Eric Klann
author_facet	Heather Bowling Aditi Bhattacharya Guoan Zhang Danyal Alam Joseph Z. Lebowitz Nathaniel Bohm-Levine Derek Lin Priyangvada Singha Maggie Mamcarz Rosemary Puckett Lili Zhou Sameer Aryal Kevin Sharp Kent Kirshenbaum Elizabeth Berry-Kravis Thomas A. Neubert Eric Klann
author_sort	Heather Bowling
title	Altered steady state and activity-dependent de novo protein expression in fragile X syndrome
title_short	Altered steady state and activity-dependent de novo protein expression in fragile X syndrome
title_full	Altered steady state and activity-dependent de novo protein expression in fragile X syndrome
title_fullStr	Altered steady state and activity-dependent de novo protein expression in fragile X syndrome
title_full_unstemmed	Altered steady state and activity-dependent de novo protein expression in fragile X syndrome
title_sort	altered steady state and activity-dependent de novo protein expression in fragile x syndrome
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0178bf18b8774f1ebc6d3278b69cc089
work_keys_str_mv	AT heatherbowling alteredsteadystateandactivitydependentdenovoproteinexpressioninfragilexsyndrome AT aditibhattacharya alteredsteadystateandactivitydependentdenovoproteinexpressioninfragilexsyndrome AT guoanzhang alteredsteadystateandactivitydependentdenovoproteinexpressioninfragilexsyndrome AT danyalalam alteredsteadystateandactivitydependentdenovoproteinexpressioninfragilexsyndrome AT josephzlebowitz alteredsteadystateandactivitydependentdenovoproteinexpressioninfragilexsyndrome AT nathanielbohmlevine alteredsteadystateandactivitydependentdenovoproteinexpressioninfragilexsyndrome AT dereklin alteredsteadystateandactivitydependentdenovoproteinexpressioninfragilexsyndrome AT priyangvadasingha alteredsteadystateandactivitydependentdenovoproteinexpressioninfragilexsyndrome AT maggiemamcarz alteredsteadystateandactivitydependentdenovoproteinexpressioninfragilexsyndrome AT rosemarypuckett alteredsteadystateandactivitydependentdenovoproteinexpressioninfragilexsyndrome AT lilizhou alteredsteadystateandactivitydependentdenovoproteinexpressioninfragilexsyndrome AT sameeraryal alteredsteadystateandactivitydependentdenovoproteinexpressioninfragilexsyndrome AT kevinsharp alteredsteadystateandactivitydependentdenovoproteinexpressioninfragilexsyndrome AT kentkirshenbaum alteredsteadystateandactivitydependentdenovoproteinexpressioninfragilexsyndrome AT elizabethberrykravis alteredsteadystateandactivitydependentdenovoproteinexpressioninfragilexsyndrome AT thomasaneubert alteredsteadystateandactivitydependentdenovoproteinexpressioninfragilexsyndrome AT ericklann alteredsteadystateandactivitydependentdenovoproteinexpressioninfragilexsyndrome
_version_	1718381946984202240

Altered steady state and activity-dependent de novo protein expression in fragile X syndrome

Ejemplares similares