Association of HLA-DQ trans-heterodimers with prevalence of type 1 diabetes mellitus in Buryat ethnic group

Aims. Search for the most pronounced HLA II markers of type 1 diabetes mellitus (T1DM) in Buryat ethnic group and analysis ofHLA-DQ trans-heterodimers. Materials and methods. Case control design was applied for assessment of 74 patients with T1DM and 61 healthy individuals. Alleleidentification wa...

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Autores principales:	Olga Nikolaevna Ivanova, Sergey Alexandrovich Prokof'ev, Tatiana Prokop'evna Bardymova
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2012
Materias:	buryat ethnic group hla ii genotype dq-heterodimers Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/017c22aef36349c889bcb9cccf7c6108
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spelling	oai:doaj.org-article:017c22aef36349c889bcb9cccf7c61082021-11-14T09:00:17ZAssociation of HLA-DQ trans-heterodimers with prevalence of type 1 diabetes mellitus in Buryat ethnic group2072-03512072-037810.14341/2072-0351-6080https://doaj.org/article/017c22aef36349c889bcb9cccf7c61082012-09-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/6080https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aims. Search for the most pronounced HLA II markers of type 1 diabetes mellitus (T1DM) in Buryat ethnic group and analysis ofHLA-DQ trans-heterodimers. Materials and methods. Case control design was applied for assessment of 74 patients with T1DM and 61 healthy individuals. Alleleidentification was performed with multi-primer allele-specific PCR technique. Association of genetic markers with pathology wasevaluated according to odds ratio (OR) index. All calculations were performed with StatSoft and STATISTICA 6 software applications. Results. We show that regarding race-specific highly diabetogenic HLA class II haplotypes Buryat ethnic group holds intermediateposition between Mongoloids and Caucasians and none of those haplotypes are associated with T1DM. We revealed a statisticallysignificant association of T1DM with DQA10301+DQB10201+ phenotype represented by trans-coding alleles in 77% of cases. Onpopulation level DQA10301+DQB10302+ or 0201+ phenotype is found to be the most sensitive marker. It was registered in 43%of patients with T1DM against 11.5% of controls (OR 5.9; рс=0.0094). DQA10301+/DQВ10201 and DQВ10302 phenotype is themost specific marker, registered in 16% of patients, but not found in controls (OR 11.8; рс=0.047).Conclusions. HLA-mediated risk for development of T1DM in Buryat ethnic group is determined by HLA-DQ trans-heterodimers.Olga Nikolaevna IvanovaSergey Alexandrovich Prokof'evTatiana Prokop'evna BardymovaEndocrinology Research Centrearticleburyatethnic grouphla ii genotypedq-heterodimersNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 15, Iss 3, Pp 11-18 (2012)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	buryat ethnic group hla ii genotype dq-heterodimers Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	buryat ethnic group hla ii genotype dq-heterodimers Nutritional diseases. Deficiency diseases RC620-627 Olga Nikolaevna Ivanova Sergey Alexandrovich Prokof'ev Tatiana Prokop'evna Bardymova Association of HLA-DQ trans-heterodimers with prevalence of type 1 diabetes mellitus in Buryat ethnic group
description	Aims. Search for the most pronounced HLA II markers of type 1 diabetes mellitus (T1DM) in Buryat ethnic group and analysis ofHLA-DQ trans-heterodimers. Materials and methods. Case control design was applied for assessment of 74 patients with T1DM and 61 healthy individuals. Alleleidentification was performed with multi-primer allele-specific PCR technique. Association of genetic markers with pathology wasevaluated according to odds ratio (OR) index. All calculations were performed with StatSoft and STATISTICA 6 software applications. Results. We show that regarding race-specific highly diabetogenic HLA class II haplotypes Buryat ethnic group holds intermediateposition between Mongoloids and Caucasians and none of those haplotypes are associated with T1DM. We revealed a statisticallysignificant association of T1DM with DQA10301+DQB10201+ phenotype represented by trans-coding alleles in 77% of cases. Onpopulation level DQA10301+DQB10302+ or 0201+ phenotype is found to be the most sensitive marker. It was registered in 43%of patients with T1DM against 11.5% of controls (OR 5.9; рс=0.0094). DQA10301+/DQВ10201 and DQВ10302 phenotype is themost specific marker, registered in 16% of patients, but not found in controls (OR 11.8; рс=0.047).Conclusions. HLA-mediated risk for development of T1DM in Buryat ethnic group is determined by HLA-DQ trans-heterodimers.
format	article
author	Olga Nikolaevna Ivanova Sergey Alexandrovich Prokof'ev Tatiana Prokop'evna Bardymova
author_facet	Olga Nikolaevna Ivanova Sergey Alexandrovich Prokof'ev Tatiana Prokop'evna Bardymova
author_sort	Olga Nikolaevna Ivanova
title	Association of HLA-DQ trans-heterodimers with prevalence of type 1 diabetes mellitus in Buryat ethnic group
title_short	Association of HLA-DQ trans-heterodimers with prevalence of type 1 diabetes mellitus in Buryat ethnic group
title_full	Association of HLA-DQ trans-heterodimers with prevalence of type 1 diabetes mellitus in Buryat ethnic group
title_fullStr	Association of HLA-DQ trans-heterodimers with prevalence of type 1 diabetes mellitus in Buryat ethnic group
title_full_unstemmed	Association of HLA-DQ trans-heterodimers with prevalence of type 1 diabetes mellitus in Buryat ethnic group
title_sort	association of hla-dq trans-heterodimers with prevalence of type 1 diabetes mellitus in buryat ethnic group
publisher	Endocrinology Research Centre
publishDate	2012
url	https://doaj.org/article/017c22aef36349c889bcb9cccf7c6108
work_keys_str_mv	AT olganikolaevnaivanova associationofhladqtransheterodimerswithprevalenceoftype1diabetesmellitusinburyatethnicgroup AT sergeyalexandrovichprokofev associationofhladqtransheterodimerswithprevalenceoftype1diabetesmellitusinburyatethnicgroup AT tatianaprokopevnabardymova associationofhladqtransheterodimerswithprevalenceoftype1diabetesmellitusinburyatethnicgroup
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Association of HLA-DQ trans-heterodimers with prevalence of type 1 diabetes mellitus in Buryat ethnic group

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