ICAM1 initiates CTC cluster formation and trans-endothelial migration in lung metastasis of breast cancer

Circulating tumor cell (CTC) clusters are more efficient at mediating metastasis as compared to single cells and are associated with poor prognosis in breast cancer. Here, the authors show that ICAM1 is enriched in CTC clusters and its loss suppresses cell-cell interaction and CTC cluster formation,...

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Autores principales:	Rokana Taftaf, Xia Liu, Salendra Singh, Yuzhi Jia, Nurmaa K. Dashzeveg, Andrew D. Hoffmann, Lamiaa El-Shennawy, Erika K. Ramos, Valery Adorno-Cruz, Emma J. Schuster, David Scholten, Dhwani Patel, Youbin Zhang, Andrew A. Davis, Carolina Reduzzi, Yue Cao, Paolo D’Amico, Yang Shen, Massimo Cristofanilli, William A. Muller, Vinay Varadan, Huiping Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/017f7ea6455b4bbfa2e1554f4c8f4748
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:017f7ea6455b4bbfa2e1554f4c8f47482021-12-02T18:50:56ZICAM1 initiates CTC cluster formation and trans-endothelial migration in lung metastasis of breast cancer10.1038/s41467-021-25189-z2041-1723https://doaj.org/article/017f7ea6455b4bbfa2e1554f4c8f47482021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25189-zhttps://doaj.org/toc/2041-1723Circulating tumor cell (CTC) clusters are more efficient at mediating metastasis as compared to single cells and are associated with poor prognosis in breast cancer. Here, the authors show that ICAM1 is enriched in CTC clusters and its loss suppresses cell-cell interaction and CTC cluster formation, and propose ICAM1 as a therapeutic target for treating breast cancer metastasis.Rokana TaftafXia LiuSalendra SinghYuzhi JiaNurmaa K. DashzevegAndrew D. HoffmannLamiaa El-ShennawyErika K. RamosValery Adorno-CruzEmma J. SchusterDavid ScholtenDhwani PatelYoubin ZhangAndrew A. DavisCarolina ReduzziYue CaoPaolo D’AmicoYang ShenMassimo CristofanilliWilliam A. MullerVinay VaradanHuiping LiuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rokana Taftaf Xia Liu Salendra Singh Yuzhi Jia Nurmaa K. Dashzeveg Andrew D. Hoffmann Lamiaa El-Shennawy Erika K. Ramos Valery Adorno-Cruz Emma J. Schuster David Scholten Dhwani Patel Youbin Zhang Andrew A. Davis Carolina Reduzzi Yue Cao Paolo D’Amico Yang Shen Massimo Cristofanilli William A. Muller Vinay Varadan Huiping Liu ICAM1 initiates CTC cluster formation and trans-endothelial migration in lung metastasis of breast cancer
description	Circulating tumor cell (CTC) clusters are more efficient at mediating metastasis as compared to single cells and are associated with poor prognosis in breast cancer. Here, the authors show that ICAM1 is enriched in CTC clusters and its loss suppresses cell-cell interaction and CTC cluster formation, and propose ICAM1 as a therapeutic target for treating breast cancer metastasis.
format	article
author	Rokana Taftaf Xia Liu Salendra Singh Yuzhi Jia Nurmaa K. Dashzeveg Andrew D. Hoffmann Lamiaa El-Shennawy Erika K. Ramos Valery Adorno-Cruz Emma J. Schuster David Scholten Dhwani Patel Youbin Zhang Andrew A. Davis Carolina Reduzzi Yue Cao Paolo D’Amico Yang Shen Massimo Cristofanilli William A. Muller Vinay Varadan Huiping Liu
author_facet	Rokana Taftaf Xia Liu Salendra Singh Yuzhi Jia Nurmaa K. Dashzeveg Andrew D. Hoffmann Lamiaa El-Shennawy Erika K. Ramos Valery Adorno-Cruz Emma J. Schuster David Scholten Dhwani Patel Youbin Zhang Andrew A. Davis Carolina Reduzzi Yue Cao Paolo D’Amico Yang Shen Massimo Cristofanilli William A. Muller Vinay Varadan Huiping Liu
author_sort	Rokana Taftaf
title	ICAM1 initiates CTC cluster formation and trans-endothelial migration in lung metastasis of breast cancer
title_short	ICAM1 initiates CTC cluster formation and trans-endothelial migration in lung metastasis of breast cancer
title_full	ICAM1 initiates CTC cluster formation and trans-endothelial migration in lung metastasis of breast cancer
title_fullStr	ICAM1 initiates CTC cluster formation and trans-endothelial migration in lung metastasis of breast cancer
title_full_unstemmed	ICAM1 initiates CTC cluster formation and trans-endothelial migration in lung metastasis of breast cancer
title_sort	icam1 initiates ctc cluster formation and trans-endothelial migration in lung metastasis of breast cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/017f7ea6455b4bbfa2e1554f4c8f4748
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ICAM1 initiates CTC cluster formation and trans-endothelial migration in lung metastasis of breast cancer

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