Change in the central control of the bladder function of rats with focal cerebral infarction induced by photochemically-induced thrombosis.

The photochemically-induced thrombosis (photothrombosis) method can create focal cerebral infarcts anywhere in the relatively superficial layers of the cerebrum; it is easy to implement and minimally invasive. Taking advantage of this versatility, we aimed to establish a new rat model of urinary fre...

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Autores principales:	Yuya Ota, Yasue Kubota, Yuji Hotta, Mami Matsumoto, Nayuka Matsuyama, Taiki Kato, Takashi Hamakawa, Tomoya Kataoka, Kazunori Kimura, Kazunobu Sawamoto, Takahiro Yasui
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0180958d959246ed86e72c154d8b769e
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spelling	oai:doaj.org-article:0180958d959246ed86e72c154d8b769e2021-12-02T20:07:43ZChange in the central control of the bladder function of rats with focal cerebral infarction induced by photochemically-induced thrombosis.1932-620310.1371/journal.pone.0255200https://doaj.org/article/0180958d959246ed86e72c154d8b769e2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255200https://doaj.org/toc/1932-6203The photochemically-induced thrombosis (photothrombosis) method can create focal cerebral infarcts anywhere in the relatively superficial layers of the cerebrum; it is easy to implement and minimally invasive. Taking advantage of this versatility, we aimed to establish a new rat model of urinary frequency with focal cerebral infarction, which was characterized by its simplicity, nonlethal nature, and high reproducibility. The prefrontal cortex and the anterior cingulate cortex, which are involved in lower urinary tract control, were targeted for focal cerebral infarction, and urinary parameters were measured by cystometrogram. Cystometric analysis indicated that micturition intervals significantly shortened in photothrombosis-treated rats compared with those in the sham operative group on Days 1 and 7 (P < 0.01), but prolonged after 14 days, with no difference between the two groups. Immunopathological evaluation showed an accumulation of activated microglia, followed by an increase in reactive astrocytes at the peri-infarct zone after photothrombotic stroke. Throughout this study, all postphotothrombosis rats showed cerebral infarction in the prefrontal cortex and anterior cingulate cortex; there were no cases of rats with fatal cerebral infarction. This model corresponded to the clinical presentation, in that the micturition status changed after stroke. In conclusion, this novel model combining nonlethality and high reproducibility may be a suitable model of urinary frequency after focal cerebral infarction.Yuya OtaYasue KubotaYuji HottaMami MatsumotoNayuka MatsuyamaTaiki KatoTakashi HamakawaTomoya KataokaKazunori KimuraKazunobu SawamotoTakahiro YasuiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0255200 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yuya Ota Yasue Kubota Yuji Hotta Mami Matsumoto Nayuka Matsuyama Taiki Kato Takashi Hamakawa Tomoya Kataoka Kazunori Kimura Kazunobu Sawamoto Takahiro Yasui Change in the central control of the bladder function of rats with focal cerebral infarction induced by photochemically-induced thrombosis.
description	The photochemically-induced thrombosis (photothrombosis) method can create focal cerebral infarcts anywhere in the relatively superficial layers of the cerebrum; it is easy to implement and minimally invasive. Taking advantage of this versatility, we aimed to establish a new rat model of urinary frequency with focal cerebral infarction, which was characterized by its simplicity, nonlethal nature, and high reproducibility. The prefrontal cortex and the anterior cingulate cortex, which are involved in lower urinary tract control, were targeted for focal cerebral infarction, and urinary parameters were measured by cystometrogram. Cystometric analysis indicated that micturition intervals significantly shortened in photothrombosis-treated rats compared with those in the sham operative group on Days 1 and 7 (P < 0.01), but prolonged after 14 days, with no difference between the two groups. Immunopathological evaluation showed an accumulation of activated microglia, followed by an increase in reactive astrocytes at the peri-infarct zone after photothrombotic stroke. Throughout this study, all postphotothrombosis rats showed cerebral infarction in the prefrontal cortex and anterior cingulate cortex; there were no cases of rats with fatal cerebral infarction. This model corresponded to the clinical presentation, in that the micturition status changed after stroke. In conclusion, this novel model combining nonlethality and high reproducibility may be a suitable model of urinary frequency after focal cerebral infarction.
format	article
author	Yuya Ota Yasue Kubota Yuji Hotta Mami Matsumoto Nayuka Matsuyama Taiki Kato Takashi Hamakawa Tomoya Kataoka Kazunori Kimura Kazunobu Sawamoto Takahiro Yasui
author_facet	Yuya Ota Yasue Kubota Yuji Hotta Mami Matsumoto Nayuka Matsuyama Taiki Kato Takashi Hamakawa Tomoya Kataoka Kazunori Kimura Kazunobu Sawamoto Takahiro Yasui
author_sort	Yuya Ota
title	Change in the central control of the bladder function of rats with focal cerebral infarction induced by photochemically-induced thrombosis.
title_short	Change in the central control of the bladder function of rats with focal cerebral infarction induced by photochemically-induced thrombosis.
title_full	Change in the central control of the bladder function of rats with focal cerebral infarction induced by photochemically-induced thrombosis.
title_fullStr	Change in the central control of the bladder function of rats with focal cerebral infarction induced by photochemically-induced thrombosis.
title_full_unstemmed	Change in the central control of the bladder function of rats with focal cerebral infarction induced by photochemically-induced thrombosis.
title_sort	change in the central control of the bladder function of rats with focal cerebral infarction induced by photochemically-induced thrombosis.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/0180958d959246ed86e72c154d8b769e
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Change in the central control of the bladder function of rats with focal cerebral infarction induced by photochemically-induced thrombosis.

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