The beneficial effects of menopausal hormone therapy on renal survival in postmenopausal Korean women from a nationwide health survey

Abstract Several studies have demonstrated the nephroprotective effects of estrogen on renal damage. In light of the inconsistent results of previous findings, this study aims to evaluate the in-depth role of menopausal hormone therapy (MHT) on the development of end stage renal disease (ESRD). 3,10...

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Autores principales:	Shin Young Ahn, Yoon Jin Choi, Jieun Kim, Gang Jee Ko, Young Joo Kwon, Kyungdo Han
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/01839f6d1c7d4971a3beef0ddcaa02c3
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spelling	oai:doaj.org-article:01839f6d1c7d4971a3beef0ddcaa02c32021-12-02T18:46:54ZThe beneficial effects of menopausal hormone therapy on renal survival in postmenopausal Korean women from a nationwide health survey10.1038/s41598-021-93847-92045-2322https://doaj.org/article/01839f6d1c7d4971a3beef0ddcaa02c32021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93847-9https://doaj.org/toc/2045-2322Abstract Several studies have demonstrated the nephroprotective effects of estrogen on renal damage. In light of the inconsistent results of previous findings, this study aims to evaluate the in-depth role of menopausal hormone therapy (MHT) on the development of end stage renal disease (ESRD). 3,109,506 Korean adult women who had undergone a medical examination in 2009 (index year) were initially identified for inclusion in this study. We excluded subjects had not experienced menopause naturally, had data missing for at least one variable, and were diagnosed with ESRD within 1 year from the index year. MHT data was obtained from self-reporting questionnaires and the primary outcome was the development of ESRD from the index year until December 31, 2018. A final total of 1,460,311 subjects were included in this study. The participants were divided into four groups according to the duration of MHT; no history of MHT, MHT < 2 years, 2 ≤ MHT < 5 years, MHT ≥ 5 years. During the 9-year study period, a total of 4905 participants developed ESRD. The participants who had a history of MHT use were found to have a 30% reduced risk of developing ESRD. Results from the subgroup analyses were similar to that of the primary study. The findings in this study demonstrate the beneficial effects of MHT on the development of ESRD in postmenopausal women. Based on results, our study may offer suggestions for further studies to investigate the therapeutic options on kidney disease.Shin Young AhnYoon Jin ChoiJieun KimGang Jee KoYoung Joo KwonKyungdo HanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shin Young Ahn Yoon Jin Choi Jieun Kim Gang Jee Ko Young Joo Kwon Kyungdo Han The beneficial effects of menopausal hormone therapy on renal survival in postmenopausal Korean women from a nationwide health survey
description	Abstract Several studies have demonstrated the nephroprotective effects of estrogen on renal damage. In light of the inconsistent results of previous findings, this study aims to evaluate the in-depth role of menopausal hormone therapy (MHT) on the development of end stage renal disease (ESRD). 3,109,506 Korean adult women who had undergone a medical examination in 2009 (index year) were initially identified for inclusion in this study. We excluded subjects had not experienced menopause naturally, had data missing for at least one variable, and were diagnosed with ESRD within 1 year from the index year. MHT data was obtained from self-reporting questionnaires and the primary outcome was the development of ESRD from the index year until December 31, 2018. A final total of 1,460,311 subjects were included in this study. The participants were divided into four groups according to the duration of MHT; no history of MHT, MHT < 2 years, 2 ≤ MHT < 5 years, MHT ≥ 5 years. During the 9-year study period, a total of 4905 participants developed ESRD. The participants who had a history of MHT use were found to have a 30% reduced risk of developing ESRD. Results from the subgroup analyses were similar to that of the primary study. The findings in this study demonstrate the beneficial effects of MHT on the development of ESRD in postmenopausal women. Based on results, our study may offer suggestions for further studies to investigate the therapeutic options on kidney disease.
format	article
author	Shin Young Ahn Yoon Jin Choi Jieun Kim Gang Jee Ko Young Joo Kwon Kyungdo Han
author_facet	Shin Young Ahn Yoon Jin Choi Jieun Kim Gang Jee Ko Young Joo Kwon Kyungdo Han
author_sort	Shin Young Ahn
title	The beneficial effects of menopausal hormone therapy on renal survival in postmenopausal Korean women from a nationwide health survey
title_short	The beneficial effects of menopausal hormone therapy on renal survival in postmenopausal Korean women from a nationwide health survey
title_full	The beneficial effects of menopausal hormone therapy on renal survival in postmenopausal Korean women from a nationwide health survey
title_fullStr	The beneficial effects of menopausal hormone therapy on renal survival in postmenopausal Korean women from a nationwide health survey
title_full_unstemmed	The beneficial effects of menopausal hormone therapy on renal survival in postmenopausal Korean women from a nationwide health survey
title_sort	beneficial effects of menopausal hormone therapy on renal survival in postmenopausal korean women from a nationwide health survey
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/01839f6d1c7d4971a3beef0ddcaa02c3
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The beneficial effects of menopausal hormone therapy on renal survival in postmenopausal Korean women from a nationwide health survey

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