On the surface effects of citrates on nano-apatites: evidence of a decreased hydrophilicity

Abstract The surface structure and hydrophilicity of synthetic nanocrystalline apatite with strongly bound citrates on their surface are here investigated at the molecular level, by combining advanced IR spectroscopy, microgravimetry and adsorption microcalorimetry. Citrate are found to form unident...

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Autores principales:	Pavlo Ivanchenko, José Manuel Delgado-López, Michele Iafisco, Jaime Gómez-Morales, Anna Tampieri, Gianmario Martra, Yuriy Sakhno
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/01847b95e57f4853a4fc8a6124cb77ba
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spelling	oai:doaj.org-article:01847b95e57f4853a4fc8a6124cb77ba2021-12-02T11:40:21ZOn the surface effects of citrates on nano-apatites: evidence of a decreased hydrophilicity10.1038/s41598-017-09376-x2045-2322https://doaj.org/article/01847b95e57f4853a4fc8a6124cb77ba2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09376-xhttps://doaj.org/toc/2045-2322Abstract The surface structure and hydrophilicity of synthetic nanocrystalline apatite with strongly bound citrates on their surface are here investigated at the molecular level, by combining advanced IR spectroscopy, microgravimetry and adsorption microcalorimetry. Citrate are found to form unidentate-like and ionic-like complexes with surface Ca2+ ions, with a surface coverage closely resembling that present in bone apatite platelets (i.e., 1 molecule/(n nm)2, with n ranging between 1.4 and 1.6). These surface complexes are part of a hydrated non-apatitic surface layer with a sub-nanometre thickness. Noticeably, it is found that the hydrophilicity of the nanoparticles, measured in terms of adsorption of water molecules in the form of multilayers, decreases in a significant extent in relation to the presence of citrates, most likely because of the exposure toward the exterior of –CH2 groups. Our findings provide new insights on the surface properties of bio-inspired nano-apatites, which can be of great relevance for better understanding the role of citrate in determining important interfacial properties, such as hydrophobicity, of bone apatite platelets. The evaluation and comprehension of surface composition and structure is also of paramount interest to strictly control the functions of synthetic biomaterials, since their surface chemistry strongly affects the hosting tissue response.Pavlo IvanchenkoJosé Manuel Delgado-LópezMichele IafiscoJaime Gómez-MoralesAnna TampieriGianmario MartraYuriy SakhnoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pavlo Ivanchenko José Manuel Delgado-López Michele Iafisco Jaime Gómez-Morales Anna Tampieri Gianmario Martra Yuriy Sakhno On the surface effects of citrates on nano-apatites: evidence of a decreased hydrophilicity
description	Abstract The surface structure and hydrophilicity of synthetic nanocrystalline apatite with strongly bound citrates on their surface are here investigated at the molecular level, by combining advanced IR spectroscopy, microgravimetry and adsorption microcalorimetry. Citrate are found to form unidentate-like and ionic-like complexes with surface Ca2+ ions, with a surface coverage closely resembling that present in bone apatite platelets (i.e., 1 molecule/(n nm)2, with n ranging between 1.4 and 1.6). These surface complexes are part of a hydrated non-apatitic surface layer with a sub-nanometre thickness. Noticeably, it is found that the hydrophilicity of the nanoparticles, measured in terms of adsorption of water molecules in the form of multilayers, decreases in a significant extent in relation to the presence of citrates, most likely because of the exposure toward the exterior of –CH2 groups. Our findings provide new insights on the surface properties of bio-inspired nano-apatites, which can be of great relevance for better understanding the role of citrate in determining important interfacial properties, such as hydrophobicity, of bone apatite platelets. The evaluation and comprehension of surface composition and structure is also of paramount interest to strictly control the functions of synthetic biomaterials, since their surface chemistry strongly affects the hosting tissue response.
format	article
author	Pavlo Ivanchenko José Manuel Delgado-López Michele Iafisco Jaime Gómez-Morales Anna Tampieri Gianmario Martra Yuriy Sakhno
author_facet	Pavlo Ivanchenko José Manuel Delgado-López Michele Iafisco Jaime Gómez-Morales Anna Tampieri Gianmario Martra Yuriy Sakhno
author_sort	Pavlo Ivanchenko
title	On the surface effects of citrates on nano-apatites: evidence of a decreased hydrophilicity
title_short	On the surface effects of citrates on nano-apatites: evidence of a decreased hydrophilicity
title_full	On the surface effects of citrates on nano-apatites: evidence of a decreased hydrophilicity
title_fullStr	On the surface effects of citrates on nano-apatites: evidence of a decreased hydrophilicity
title_full_unstemmed	On the surface effects of citrates on nano-apatites: evidence of a decreased hydrophilicity
title_sort	on the surface effects of citrates on nano-apatites: evidence of a decreased hydrophilicity
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/01847b95e57f4853a4fc8a6124cb77ba
work_keys_str_mv	AT pavloivanchenko onthesurfaceeffectsofcitratesonnanoapatitesevidenceofadecreasedhydrophilicity AT josemanueldelgadolopez onthesurfaceeffectsofcitratesonnanoapatitesevidenceofadecreasedhydrophilicity AT micheleiafisco onthesurfaceeffectsofcitratesonnanoapatitesevidenceofadecreasedhydrophilicity AT jaimegomezmorales onthesurfaceeffectsofcitratesonnanoapatitesevidenceofadecreasedhydrophilicity AT annatampieri onthesurfaceeffectsofcitratesonnanoapatitesevidenceofadecreasedhydrophilicity AT gianmariomartra onthesurfaceeffectsofcitratesonnanoapatitesevidenceofadecreasedhydrophilicity AT yuriysakhno onthesurfaceeffectsofcitratesonnanoapatitesevidenceofadecreasedhydrophilicity
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On the surface effects of citrates on nano-apatites: evidence of a decreased hydrophilicity

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