Linking chronic infection and autoimmune diseases: Mycobacterium avium subspecies paratuberculosis, SLC11A1 polymorphisms and type-1 diabetes mellitus.

<h4>Background</h4>The etiology of type 1 diabetes mellitus (T1DM) is still unknown; numerous studies are performed to unravel the environmental factors involved in triggering the disease. SLC11A1 is a membrane transporter that is expressed in late endosomes of antigen presenting cells i...

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Autores principales:	Daniela Paccagnini, Lee Sieswerda, Valentina Rosu, Speranza Masala, Adolfo Pacifico, Maria Gazouli, John Ikonomopoulos, Niyaz Ahmed, Stefania Zanetti, Leonardo A Sechi
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/01864555fc56406193ff9c4d0f3fa121
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spelling	oai:doaj.org-article:01864555fc56406193ff9c4d0f3fa1212021-11-25T06:20:16ZLinking chronic infection and autoimmune diseases: Mycobacterium avium subspecies paratuberculosis, SLC11A1 polymorphisms and type-1 diabetes mellitus.1932-620310.1371/journal.pone.0007109https://doaj.org/article/01864555fc56406193ff9c4d0f3fa1212009-09-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19768110/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The etiology of type 1 diabetes mellitus (T1DM) is still unknown; numerous studies are performed to unravel the environmental factors involved in triggering the disease. SLC11A1 is a membrane transporter that is expressed in late endosomes of antigen presenting cells involved in the immunopathogenic events leading to T1DM. Mycobacterium avium subsp. paratuberculosis (MAP) has been reported to be a possible trigger in the development of T1DM.<h4>Methodology/principal findings</h4>Fifty nine T1DM patients and 79 healthy controls were genotyped for 9 polymorphisms of SLC11A1 gene, and screened for the presence of MAP by PCR. Differences in genotype frequency were evaluated for both T1DM patients and controls. We found a polymorphism in the SLC11A1 gene (274C/T) associated to type 1 diabetic patients and not to controls. The presence of MAP DNA was also significantly associated with T1DM patients and not with controls.<h4>Conclusions/significance</h4>The 274C/T SCL11A1 polymorphism was found to be associated with T1DM as well as the presence of MAP DNA in blood. Since MAP persists within macrophages and it is also processed by dendritic cells, further studies are necessary to evaluate if mutant forms of SLC11A1 alter the processing or presentation of MAP antigens triggering thereby an autoimmune response in T1DM patients.Daniela PaccagniniLee SieswerdaValentina RosuSperanza MasalaAdolfo PacificoMaria GazouliJohn IkonomopoulosNiyaz AhmedStefania ZanettiLeonardo A SechiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 4, Iss 9, p e7109 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Daniela Paccagnini Lee Sieswerda Valentina Rosu Speranza Masala Adolfo Pacifico Maria Gazouli John Ikonomopoulos Niyaz Ahmed Stefania Zanetti Leonardo A Sechi Linking chronic infection and autoimmune diseases: Mycobacterium avium subspecies paratuberculosis, SLC11A1 polymorphisms and type-1 diabetes mellitus.
description	<h4>Background</h4>The etiology of type 1 diabetes mellitus (T1DM) is still unknown; numerous studies are performed to unravel the environmental factors involved in triggering the disease. SLC11A1 is a membrane transporter that is expressed in late endosomes of antigen presenting cells involved in the immunopathogenic events leading to T1DM. Mycobacterium avium subsp. paratuberculosis (MAP) has been reported to be a possible trigger in the development of T1DM.<h4>Methodology/principal findings</h4>Fifty nine T1DM patients and 79 healthy controls were genotyped for 9 polymorphisms of SLC11A1 gene, and screened for the presence of MAP by PCR. Differences in genotype frequency were evaluated for both T1DM patients and controls. We found a polymorphism in the SLC11A1 gene (274C/T) associated to type 1 diabetic patients and not to controls. The presence of MAP DNA was also significantly associated with T1DM patients and not with controls.<h4>Conclusions/significance</h4>The 274C/T SCL11A1 polymorphism was found to be associated with T1DM as well as the presence of MAP DNA in blood. Since MAP persists within macrophages and it is also processed by dendritic cells, further studies are necessary to evaluate if mutant forms of SLC11A1 alter the processing or presentation of MAP antigens triggering thereby an autoimmune response in T1DM patients.
format	article
author	Daniela Paccagnini Lee Sieswerda Valentina Rosu Speranza Masala Adolfo Pacifico Maria Gazouli John Ikonomopoulos Niyaz Ahmed Stefania Zanetti Leonardo A Sechi
author_facet	Daniela Paccagnini Lee Sieswerda Valentina Rosu Speranza Masala Adolfo Pacifico Maria Gazouli John Ikonomopoulos Niyaz Ahmed Stefania Zanetti Leonardo A Sechi
author_sort	Daniela Paccagnini
title	Linking chronic infection and autoimmune diseases: Mycobacterium avium subspecies paratuberculosis, SLC11A1 polymorphisms and type-1 diabetes mellitus.
title_short	Linking chronic infection and autoimmune diseases: Mycobacterium avium subspecies paratuberculosis, SLC11A1 polymorphisms and type-1 diabetes mellitus.
title_full	Linking chronic infection and autoimmune diseases: Mycobacterium avium subspecies paratuberculosis, SLC11A1 polymorphisms and type-1 diabetes mellitus.
title_fullStr	Linking chronic infection and autoimmune diseases: Mycobacterium avium subspecies paratuberculosis, SLC11A1 polymorphisms and type-1 diabetes mellitus.
title_full_unstemmed	Linking chronic infection and autoimmune diseases: Mycobacterium avium subspecies paratuberculosis, SLC11A1 polymorphisms and type-1 diabetes mellitus.
title_sort	linking chronic infection and autoimmune diseases: mycobacterium avium subspecies paratuberculosis, slc11a1 polymorphisms and type-1 diabetes mellitus.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/01864555fc56406193ff9c4d0f3fa121
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Linking chronic infection and autoimmune diseases: Mycobacterium avium subspecies paratuberculosis, SLC11A1 polymorphisms and type-1 diabetes mellitus.

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