Neuroinflammation and Modulation Role of Natural Products After Spinal Cord Injury

Xue Wu, Yaping Yan, Qian Zhang National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, The Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry, The Ministry of Education, College of Life Sciences, Shaanxi Normal University, Xi’an,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Wu X, Yan Y, Zhang Q
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	spinal cord injury neuroinflammation blood-spinal cord barrier microglia astrocytes natural products Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/0186d64cc52d4b1d94cfca98caa02320
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0186d64cc52d4b1d94cfca98caa02320
record_format	dspace
spelling	oai:doaj.org-article:0186d64cc52d4b1d94cfca98caa023202021-12-02T17:54:55ZNeuroinflammation and Modulation Role of Natural Products After Spinal Cord Injury1178-7031https://doaj.org/article/0186d64cc52d4b1d94cfca98caa023202021-11-01T00:00:00Zhttps://www.dovepress.com/neuroinflammation-and-modulation-role-of-natural-products-after-spinal-peer-reviewed-fulltext-article-JIRhttps://doaj.org/toc/1178-7031Xue Wu, Yaping Yan, Qian Zhang National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, The Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry, The Ministry of Education, College of Life Sciences, Shaanxi Normal University, Xi’an, Shaanxi, The People’s Republic of ChinaCorrespondence: Qian Zhang Email zhangqian154@snnu.edu.cnAbstract: Spinal cord injury (SCI) is a severe traumatic injury of the central nervous system, characterized by neurological dysfunction and locomotor disability. Although the underlying pathological mechanism of SCI is complex and remains unclear, the important role of neuroinflammation has been gradually unveiled in recent years. The inflammation process after SCI involves disruption of the blood–spinal cord barrier (BSCB), activation of gliocytes, infiltration of peripheral macrophages, and feedback loops between different cells. Thus, our first aim is to illustrate pathogenesis, related cells and factors of neuroinflammation after SCI in this review. Due to the good bioactivity of natural products derived from plants and medicinal herbs, these widely exist as food, health-care products and drugs in our lives. In the inflammation after SCI, multiple natural products exert satisfactory effects. Therefore, the second aim of this review is to sum up the effects and mechanisms of 25 natural compounds and 7 extracts derived from plants or medicinal herbs on neuroinflammation after SCI. Clarification of the SCI inflammation mechanism and a summary of the related natural products is helpful for in-depth research and drug development.Keywords: spinal cord injury, neuroinflammation, blood-spinal cord barrier, microglia, astrocytes, natural productsWu XYan YZhang QDove Medical Pressarticlespinal cord injuryneuroinflammationblood-spinal cord barriermicrogliaastrocytesnatural productsPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 5713-5737 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	spinal cord injury neuroinflammation blood-spinal cord barrier microglia astrocytes natural products Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	spinal cord injury neuroinflammation blood-spinal cord barrier microglia astrocytes natural products Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Wu X Yan Y Zhang Q Neuroinflammation and Modulation Role of Natural Products After Spinal Cord Injury
description	Xue Wu, Yaping Yan, Qian Zhang National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, The Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry, The Ministry of Education, College of Life Sciences, Shaanxi Normal University, Xi’an, Shaanxi, The People’s Republic of ChinaCorrespondence: Qian Zhang Email zhangqian154@snnu.edu.cnAbstract: Spinal cord injury (SCI) is a severe traumatic injury of the central nervous system, characterized by neurological dysfunction and locomotor disability. Although the underlying pathological mechanism of SCI is complex and remains unclear, the important role of neuroinflammation has been gradually unveiled in recent years. The inflammation process after SCI involves disruption of the blood–spinal cord barrier (BSCB), activation of gliocytes, infiltration of peripheral macrophages, and feedback loops between different cells. Thus, our first aim is to illustrate pathogenesis, related cells and factors of neuroinflammation after SCI in this review. Due to the good bioactivity of natural products derived from plants and medicinal herbs, these widely exist as food, health-care products and drugs in our lives. In the inflammation after SCI, multiple natural products exert satisfactory effects. Therefore, the second aim of this review is to sum up the effects and mechanisms of 25 natural compounds and 7 extracts derived from plants or medicinal herbs on neuroinflammation after SCI. Clarification of the SCI inflammation mechanism and a summary of the related natural products is helpful for in-depth research and drug development.Keywords: spinal cord injury, neuroinflammation, blood-spinal cord barrier, microglia, astrocytes, natural products
format	article
author	Wu X Yan Y Zhang Q
author_facet	Wu X Yan Y Zhang Q
author_sort	Wu X
title	Neuroinflammation and Modulation Role of Natural Products After Spinal Cord Injury
title_short	Neuroinflammation and Modulation Role of Natural Products After Spinal Cord Injury
title_full	Neuroinflammation and Modulation Role of Natural Products After Spinal Cord Injury
title_fullStr	Neuroinflammation and Modulation Role of Natural Products After Spinal Cord Injury
title_full_unstemmed	Neuroinflammation and Modulation Role of Natural Products After Spinal Cord Injury
title_sort	neuroinflammation and modulation role of natural products after spinal cord injury
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/0186d64cc52d4b1d94cfca98caa02320
work_keys_str_mv	AT wux neuroinflammationandmodulationroleofnaturalproductsafterspinalcordinjury AT yany neuroinflammationandmodulationroleofnaturalproductsafterspinalcordinjury AT zhangq neuroinflammationandmodulationroleofnaturalproductsafterspinalcordinjury
_version_	1718379149193641984

Neuroinflammation and Modulation Role of Natural Products After Spinal Cord Injury

Ejemplares similares